open access

Vol 72, No 6 (2021)
Original paper
Submitted: 2021-03-31
Accepted: 2021-06-30
Early publication date: 2021-08-06
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Non-linear associations of body mass index with impaired fasting glucose, β-cell dysfunction, and insulin resistance in nondiabetic Chinese individuals: a cross-sectional study

Min Chen12, Ruihua Yang3, Ying Wang4, Yumei Jia1, Jia Liu1, Guang Wang1
DOI: 10.5603/EP.a2021.0073
·
Pubmed: 34378785
·
Endokrynologia Polska 2021;72(6):618-624.
Affiliations
  1. Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
  2. Department of Endocrinology, Fu Xing Hospital, Capital Medical University, Beijing, China
  3. Department of Endocrinology, Beijing First Hospital of Integrated Chinese and Western Medicine, Beijing, China
  4. The Physical Examination Centre, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

open access

Vol 72, No 6 (2021)
Original Paper
Submitted: 2021-03-31
Accepted: 2021-06-30
Early publication date: 2021-08-06

Abstract

Introduction: Identifying and managing patients with prediabetes is important. The study aims to investigate the association of body mass index (BMI) with impaired fasting glucose (IFG), β-cell dysfunction, and insulin resistance in nondiabetic Chinese individuals.

Material and methods: This was a cross-sectional study of consecutive nondiabetic individuals enrolled between January 2014 and January 2015, divided into NFG [normal fasting glucose, fasting blood glucose (FBG) < 5.6 mmol/L) and IFG (n = 450; FBG ≥ 5.6 mmol/L) groups. Restricted cubic splines and piecewise-regression were used to model the association of IFG, impaired b-cell function, and insulin resistance with BMI. Stratified analyses were performed across sex and age.

Results: A total of 900 NFG and 450 IFG individuals were enrolled, with a median age of 41 (30–49) years and 1076 males (79.7%). After adjusting for age and sex, the restricted cubic splines showed that the risk of IFG was increasing rapidly until around 27.96 kg/m2 of BMI and then started to plateau afterward (p for non-linearity = 0.010), which was similar in males and individuals ≤ 45 years old (p for nonlinearity < 0.001 and = 0.007, respectively). The risk of insulin resistance increased and  β-cell dysfunction decreased as the BMI increased in all participants (both p for non-linearity > 0.05), consistent with the results in males, females, and ≤ 45 and > 45 year olds.

Conclusions: The risk of IFG does not rise linearly as the BMI increases, and higher BMI seems to decelerate the rise of the risk.

Abstract

Introduction: Identifying and managing patients with prediabetes is important. The study aims to investigate the association of body mass index (BMI) with impaired fasting glucose (IFG), β-cell dysfunction, and insulin resistance in nondiabetic Chinese individuals.

Material and methods: This was a cross-sectional study of consecutive nondiabetic individuals enrolled between January 2014 and January 2015, divided into NFG [normal fasting glucose, fasting blood glucose (FBG) < 5.6 mmol/L) and IFG (n = 450; FBG ≥ 5.6 mmol/L) groups. Restricted cubic splines and piecewise-regression were used to model the association of IFG, impaired b-cell function, and insulin resistance with BMI. Stratified analyses were performed across sex and age.

Results: A total of 900 NFG and 450 IFG individuals were enrolled, with a median age of 41 (30–49) years and 1076 males (79.7%). After adjusting for age and sex, the restricted cubic splines showed that the risk of IFG was increasing rapidly until around 27.96 kg/m2 of BMI and then started to plateau afterward (p for non-linearity = 0.010), which was similar in males and individuals ≤ 45 years old (p for nonlinearity < 0.001 and = 0.007, respectively). The risk of insulin resistance increased and  β-cell dysfunction decreased as the BMI increased in all participants (both p for non-linearity > 0.05), consistent with the results in males, females, and ≤ 45 and > 45 year olds.

Conclusions: The risk of IFG does not rise linearly as the BMI increases, and higher BMI seems to decelerate the rise of the risk.

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Keywords

insulin-secreting cells; insulin resistance; blood glucose; body mass index

About this article
Title

Non-linear associations of body mass index with impaired fasting glucose, β-cell dysfunction, and insulin resistance in nondiabetic Chinese individuals: a cross-sectional study

Journal

Endokrynologia Polska

Issue

Vol 72, No 6 (2021)

Article type

Original paper

Pages

618-624

Early publication date

2021-08-06

Page views

599

Article views/downloads

32

DOI

10.5603/EP.a2021.0073

Pubmed

34378785

Bibliographic record

Endokrynologia Polska 2021;72(6):618-624.

Keywords

insulin-secreting cells
insulin resistance
blood glucose
body mass index

Authors

Min Chen
Ruihua Yang
Ying Wang
Yumei Jia
Jia Liu
Guang Wang

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