Vol 72, No 5 (2021)
Brief communication
Published online: 2021-07-12

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Retrospective analysis of 23 Chinese children with congenital hyperinsulinism undergoing pancreatectomy

Lin Zhang1, Zi-Di Xu1, Min Liu1, Qiao Zeng1, Rong-Min Li2, Jie-Ying Wang2, Huan-Min Wang3, Long Li4, Hong Qin3, Jie Yan1, Yu-Jun Wu1, Cheng Zhu1, Gui-Chen Ni1, Yan-Mei Sang1
Pubmed: 34292572
Endokrynol Pol 2021;72(5):584-585.

Abstract

Introduction: The aim of the study was to discuss therapeutic effect and prognosis of pancreatectomy in the treatment of congenital hyperinsulinism (CHI).

Material and methods: A total of 23 Chinese children with CHI, who had undergone pancreatectomy, were selected as the study objects. The clinical data, the results of the 18Fluoro-L-3-4 dihydroxyphenylalanine positron emission tomography/computerized tomography (18F-DOPA PET/CT) scanning, and the diagnosis, treatment, and follow-up were analysed retrospectively.

Results: Among the 23 cases, 14 patients were diagnosed with focal-type CHI via a 18F-DOPA PET/CT scan prior to the operation, with the lesions removed via partial pancreatectomy. After the operation, ten patients (71%) had normal blood glucose levels, while frequent feeding was required in four patients (29%) to control the hypoglycaemia. Three cases were diagnosed as diffuse-type CHI via preoperative scanning, two of which were treated by subtotal pancreatectomy. The other case was treated by near-total pancreatectomy, and the blood glucose level was normal following the operation. The remaining six cases were not diagnosed via the pancreatic scanning prior to the operation due to the limitation of certain conditions. Here, pancreatectomy was performed directly due to severe hypoglycaemia.

Conclusions: 18F-DOPA PET/CT scanning was a reliable method for determining the histological type and localizing the lesion before the operation. Partial pancreatectomy for focal-type CHI had a high cure rate. 

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References

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