open access

Ahead of print
Clinical vignette
Published online: 2021-05-31
Submitted: 2021-04-02
Accepted: 2021-05-08
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Pembrolizumab-induced diabetes

Rumaisa Banatwalla, Omar Zuhair Kirresh, Fahad Wali Ahmed
DOI: 10.5603/EP.a2021.0053
·
Pubmed: 34057191

open access

Ahead of print
Clinical Vignette
Published online: 2021-05-31
Submitted: 2021-04-02
Accepted: 2021-05-08

Abstract

Not required for Clinical Vignette.

Abstract

Not required for Clinical Vignette.

Get Citation

Keywords

pembrolizumab; diabetes; diabetic ketoacidosis; malignant melanoma; check-point inhibitors

About this article
Title

Pembrolizumab-induced diabetes

Journal

Endokrynologia Polska

Issue

Ahead of print

Article type

Clinical vignette

Published online

2021-05-31

DOI

10.5603/EP.a2021.0053

Pubmed

34057191

Keywords

pembrolizumab
diabetes
diabetic ketoacidosis
malignant melanoma
check-point inhibitors

Authors

Rumaisa Banatwalla
Omar Zuhair Kirresh
Fahad Wali Ahmed

References (6)
  1. Abdel-Wahab N, Shah M, Suarez-Almazor ME. Adverse Events Associated with Immune Checkpoint Blockade in Patients with Cancer: A Systematic Review of Case Reports. PLoS One. 2016; 11(7): e0160221.
  2. Ishida M, Iwai Y, Tanaka Y, et al. Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues. Immunol Lett. 2002; 84(1): 57–62.
  3. Colli ML, Hill JLE, Marroquí L, et al. PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction. EBioMedicine. 2018; 36: 367–375.
  4. Clotman K, Janssens K, Specenier P, et al. Programmed Cell Death-1 Inhibitor-Induced Type 1 Diabetes Mellitus. J Clin Endocrinol Metab. 2018; 103(9): 3144–3154.
  5. Stamatouli AM, Quandt Z, Perdigoto AL, et al. Collateral Damage: Insulin-Dependent Diabetes Induced With Checkpoint Inhibitors. Diabetes. 2018; 67(8): 1471–1480.
  6. Eshet Y, Baruch EN, Shapira-Frommer R, et al. Clinical Significance of Pancreatic Atrophy Induced by Immune-Checkpoint Inhibitors: A Case-Control Study. Cancer Immunol Res. 2018; 6(12): 1453–1458.

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