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Amino acids profile in girls with Turner syndrome during growth hormone therapy
, 1, 2, 2, 1
Affiliations- Department of Clinical Biochemistry, Institute of Paediatrics, Jagiellonian University Medical College, Krakow, Poland
- Department of Paediatric and Adolescent Endocrinology, Institute of Paediatrics, Jagiellonian University, Medical College, Krakow, Poland
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Abstract
Introduction: The influence of growth hormone (GH) treatment on amino acids (AAs) profile in patients with Turner syndrome (TS) was investigated.
Material and methods: The study group included girls with TS: treated with GH (GH+) and girls with no GH treatment (GH−). The control group consisted of healthy girls. Free plasma AAs were measured by the LC/MS/MS.
Results: The plasma concentrations of glutamine, threonine were significantly higher in group GH+ than in group GH− (p < 0.05). In group GH− the values of glutamine, alanine, isoleucine, glutamic acid were significantly different than in the control (p < 0.05–p < 0.008).
Conclusion: AAs profile in girls with TS might be characteristic for the disease but also depends on GH treatment.
Abstract
Introduction: The influence of growth hormone (GH) treatment on amino acids (AAs) profile in patients with Turner syndrome (TS) was investigated.
Material and methods: The study group included girls with TS: treated with GH (GH+) and girls with no GH treatment (GH−). The control group consisted of healthy girls. Free plasma AAs were measured by the LC/MS/MS.
Results: The plasma concentrations of glutamine, threonine were significantly higher in group GH+ than in group GH− (p < 0.05). In group GH− the values of glutamine, alanine, isoleucine, glutamic acid were significantly different than in the control (p < 0.05–p < 0.008).
Conclusion: AAs profile in girls with TS might be characteristic for the disease but also depends on GH treatment.
Keywords
amino acids, growth hormone, Turner syndrome
About this articleTitle
Amino acids profile in girls with Turner syndrome during growth hormone therapy
Journal
Issue
Article type
Brief communication
Pages
51-52
Published online
2021-01-19
Page views
925
Article views/downloads
597
DOI
Pubmed
Bibliographic record
Endokrynol Pol 2021;72(1):51-52.
Keywords
amino acids
growth hormone
Turner syndrome
Authors
Jolanta Bugajska
Joanna Berska
Małgorzata Wójcik
Jerzy B. Starzyk
Krystyna Sztefko
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