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Peripheral levels of selected adipokines in patients with newly diagnosed multiple sclerosis
, 2, 3, 3, 3, 2, 3, 2
Affiliations- Department of Endocrinology, Centre of Postgraduate Medical Education, Bielański Hospital, Warsaw, Poland
- Department of Neurology, Faculty of Medicine, Medical University of Warsaw, Bielański Hospital, Warsaw, Poland
- Department of Neuroendocrinology, Centre of Postgraduate Medical Education, Warsaw, Poland
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Abstract
Introduction: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system. The exact aetiology is unknown. However, genetic and environmental factors are suggested to be involved in the pathogenesis of MS. Improper diet, resulting in obesity and metabolic syndrome, can contribute to this disease. Adipokines, secreted by adipose tissue, link the metabolism and immune system.
Material and methods: We aimed to assess plasma levels of selected adipokines in newly diagnosed, treatment-naïve individuals with multiple sclerosis. Our group comprised 58 individuals (31 MS patients and 27 controls, matched for age and BMI) without diabetes, hypertension, or dyslipidaemia. Circulating adiponectin and all adiponectin fractions, visfatin, and omentin concentrations were measured. Metabolic parameters were also assessed.
Results: In MS individuals we observed the following results: higher concentrations of visfatin, lower levels of omentin, and no differences in adiponectin array. There were also correlations between some adipokines and metabolic parameters. After adjustment to BMI, a significant decrease in total adiponectin, high-molecular weight (HMW) adiponectin and omentin, and an increase in medium-molecular-weight (MMW) adiponectin were observed in the group of MS patients when compared to those of the controls.
Conclusions: Our results indicate that adiponectin with its fractions, visfatin, and omentin cannot be considered as causative factors in the early phase of multiple sclerosis. However, the potential role of adipokines in MS is possible because they might be involved in the pathogenesis of MS, regarded as an autoimmune disorder.
Abstract
Introduction: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system. The exact aetiology is unknown. However, genetic and environmental factors are suggested to be involved in the pathogenesis of MS. Improper diet, resulting in obesity and metabolic syndrome, can contribute to this disease. Adipokines, secreted by adipose tissue, link the metabolism and immune system.
Material and methods: We aimed to assess plasma levels of selected adipokines in newly diagnosed, treatment-naïve individuals with multiple sclerosis. Our group comprised 58 individuals (31 MS patients and 27 controls, matched for age and BMI) without diabetes, hypertension, or dyslipidaemia. Circulating adiponectin and all adiponectin fractions, visfatin, and omentin concentrations were measured. Metabolic parameters were also assessed.
Results: In MS individuals we observed the following results: higher concentrations of visfatin, lower levels of omentin, and no differences in adiponectin array. There were also correlations between some adipokines and metabolic parameters. After adjustment to BMI, a significant decrease in total adiponectin, high-molecular weight (HMW) adiponectin and omentin, and an increase in medium-molecular-weight (MMW) adiponectin were observed in the group of MS patients when compared to those of the controls.
Conclusions: Our results indicate that adiponectin with its fractions, visfatin, and omentin cannot be considered as causative factors in the early phase of multiple sclerosis. However, the potential role of adipokines in MS is possible because they might be involved in the pathogenesis of MS, regarded as an autoimmune disorder.
Keywords
adiponectin; adiponectin fractions; visfatin; omentin; multiple sclerosis
About this articleTitle
Peripheral levels of selected adipokines in patients with newly diagnosed multiple sclerosis
Journal
Issue
Article type
Original paper
Pages
109-115
Published online
2020-03-04
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1763
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895
DOI
Pubmed
Bibliographic record
Endokrynol Pol 2020;71(2):109-115.
Keywords
adiponectin
adiponectin fractions
visfatin
omentin
multiple sclerosis
Authors
Agnieszka Baranowska-Bik
Dorota Uchman
Anna Litwiniuk
Małgorzata Kalisz
Lidia Martyńska
Bogusława Baranowska
Wojciech Bik
Jan Kochanowski
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