Multimedialna platforma wiedzy medycznej Internetowa Księgarnia Medyczna Kalendarium Konferencji
Endokrynologia Polska
MENU
Shortcuts Submit an article Author Guidelines Polish Society of Endocrinology Reviewers 2023 Redeem voucher

open access

Vol 71, No 1 (2020)
Review paper
Submitted: 2019-09-30
Accepted: 2019-10-01
Published online: 2020-02-24
View PDF Download PDF file
Get Citation

Can Hashimoto's thyroiditis cause vertigo? [Czy choroba Hashimoto może być przyczyną zawrotów głowy?]

Katarzyna A. Miśkiewicz-Orczyk1, Grażyna Lisowska1, Dariusz Kajdaniuk2, Matuesz Wojtulek1
DOI: 10.5603/EP.a2019.0069
·
Pubmed: 32129465
·
Endokrynol Pol 2020;71(1):76-86.
Affiliations
  1. Department of Otorhinolaryngology and Laryngological Oncology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Zabrze, Poland
  2. Department of Pathophysiology and Endocrinology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Zabrze, Poland

open access

Vol 71, No 1 (2020)
Review Article
Submitted: 2019-09-30
Accepted: 2019-10-01
Published online: 2020-02-24

Abstract

Vertigo and balance disorders are common symptoms reported by approximately 15–20% of the adult population worldwide. For many years thyroid diseases have been suspected as the cause of vertigo by ENT physicians. Almost every patient hospitalised due to severe vertigo is investigated for thyroid disease as a suspected cause of acute vestibulopathy. The issue presented in this paper is related to a difficult and poorly understood relationship between autoimmune thyroid disease and peripheral vertigo.

Abstract

Vertigo and balance disorders are common symptoms reported by approximately 15–20% of the adult population worldwide. For many years thyroid diseases have been suspected as the cause of vertigo by ENT physicians. Almost every patient hospitalised due to severe vertigo is investigated for thyroid disease as a suspected cause of acute vestibulopathy. The issue presented in this paper is related to a difficult and poorly understood relationship between autoimmune thyroid disease and peripheral vertigo.

Full Text:

View PDF Download PDF file
Get Citation

Keywords

vertigo; Hashimoto’s thyroiditis; benign paroxysmal positional vertigo; Meniere’s disease

About this article
Title

Can Hashimoto's thyroiditis cause vertigo? [Czy choroba Hashimoto może być przyczyną zawrotów głowy?]

Journal

Endokrynologia Polska

Issue

Vol 71, No 1 (2020)

Article type

Review paper

Pages

76-86

Published online

2020-02-24

Page views

11635

Article views/downloads

5442

DOI

10.5603/EP.a2019.0069

Pubmed

32129465

Bibliographic record

Endokrynol Pol 2020;71(1):76-86.

Keywords

vertigo
Hashimoto’s thyroiditis
benign paroxysmal positional vertigo
Meniere’s disease

Authors

Katarzyna A. Miśkiewicz-Orczyk
Grażyna Lisowska
Dariusz Kajdaniuk
Matuesz Wojtulek

References (77)
  1. Neuhauser HK. The epidemiology of dizziness and vertigo. Handb Clin Neurol. 2016; 137: 67–82.
    CrossRefPubMed
  2. Bhattacharyya N, Gubbels SP, Schwartz SR, et al. Clinical Practice Guideline: Benign Paroxysmal Positional Vertigo (Update). Otolaryngol Head Neck Surg. 2017; 156(3_suppl): S1–S47.
    CrossRefPubMed
  3. von Brevern M, Bertholon P, Brandt T, et al. Benign paroxysmal positional vertigo: Diagnostic criteria. J Vestib Res. 2015; 25(3–4): 105–117.
    CrossRefPubMed
  4. Oron Y, Cohen-Atsmoni S, Len A, et al. Treatment of horizontal canal BPPV: pathophysiology, available maneuvers, and recommended treatment. Laryngoscope. 2015; 125(8): 1959–1964.
    CrossRefPubMed
  5. Tirelli G, Nicastro L, Gatto A, et al. Repeated canalith repositioning procedure in BPPV: Effects on recurrence and dizziness prevention. Am J Otolaryngol. 2017; 38(1): 38–43.
    CrossRefPubMed
  6. Shea JJ. Classification of Menière's disease. Am J Otol. 1993; 14(3): 224–229.
    PubMed
  7. Goebel JA. 2015 Equilibrium Committee Amendment to the 1995 AAO-HNS Guidelines for the Definition of Ménière's Disease. Otolaryngol Head Neck Surg. 2016; 154(3): 403–404.
    CrossRefPubMed
  8. Lopez-Escamez JA, Carey J, Chung WH, et al. [Diagnostic criteria for Menière's disease according to the Classification Committee of the Bárány Society]. HNO. 2017; 65(11): 887–893.
    CrossRefPubMed
  9. Espinosa-Sanchez JM, Lopez-Escamez JA. Menière's disease. Handb Clin Neurol. 2016; 137: 257–277.
    CrossRefPubMed
  10. Tamura T. [Studies on the correlation between thyroid function and M'eni'ere's syndrome]. Nihon Jibiinkoka Gakkai Kaiho. 1964; 67: 1434–1468.
    CrossRefPubMed
  11. Modugno GC, Pirodda A, Ferri GG, et al. A relationship between autoimmune thyroiditis and benign paroxysmal positional vertigo? Med Hypotheses. 2000; 54(4): 614–615.
    CrossRefPubMed
  12. Kim SH, Kim JY, Lee HJ, et al. Autoimmunity as a candidate for the etiopathogenesis of Meniere's disease: detection of autoimmune reactions and diagnostic biomarker candidate. PLoS One. 2014; 9(10): e111039.
    CrossRefPubMed
  13. Greco A, Gallo A, Fusconi M, et al. Meniere's disease might be an autoimmune condition? Autoimmun Rev. 2012; 11(10): 731–738.
    CrossRefPubMed
  14. Santosh UP, Rao MS. Incidence of Hypothyroidism in Meniere's Disease. J Clin Diagn Res. 2016; 10(5): MC01–MC03.
    CrossRefPubMed
  15. Lok U, Hatipoglu S, Gulacti U, et al. The role of thyroid and parathyroid metabolism disorders in the etiology of sudden onset dizziness. Med Sci Monit. 2014; 20: 2689–2694.
    CrossRefPubMed
  16. Caturegli P, De Remigis A, Rose NR. Hashimoto thyroiditis: clinical and diagnostic criteria. Autoimmun Rev. 2014; 13(4-5): 391–397.
    CrossRefPubMed
  17. Hu S, Rayman MP. Multiple Nutritional Factors and the Risk of Hashimoto's Thyroiditis. Thyroid. 2017; 27(5): 597–610.
    CrossRefPubMed
  18. Liontiris MI, Mazokopakis EE. A concise review of Hashimoto thyroiditis (HT) and the importance of iodine, selenium, vitamin D and gluten on the autoimmunity and dietary management of HT patients.Points that need more investigation. Hell J Nucl Med. 2017; 20(1): 51–56.
    CrossRefPubMed
  19. McLeod DSA, Cooper DS. The incidence and prevalence of thyroid autoimmunity. Endocrine. 2012; 42(2): 252–265.
    CrossRefPubMed
  20. Cho BY, Shong YK, Lee HK, et al. Role of blocking TSH receptor antibodies on the development of hypothyroidism and thyroid atrophy in primary myxedema. Korean J Intern Med. 1989; 4(2): 108–117.
    CrossRefPubMed
  21. Kim D. Low vitamin D status is associated with hypothyroid Hashimoto's thyroiditis. Hormones (Athens). 2016; 15(3): 385–393.
    CrossRefPubMed
  22. Ke W, Sun T, Zhang Y, et al. 25-Hydroxyvitamin D serum level in Hashimoto's thyroiditis, but not Graves' disease is relatively deficient. Endocr J. 2017; 64(6): 581–587.
    CrossRefPubMed
  23. Rayman MP. Multiple nutritional factors and thyroid disease, with particular reference to autoimmune thyroid disease. Proc Nutr Soc. 2019; 78(1): 34–44.
    CrossRefPubMed
  24. Zhernakova A, Withoff S, Wijmenga C. Clinical implications of shared genetics and pathogenesis in autoimmune diseases. Nat Rev Endocrinol. 2013; 9(11): 646–659.
    CrossRefPubMed
  25. Li Y, Nishihara E, Kakudo K. Hashimoto's thyroiditis: old concepts and new insights. Curr Opin Rheumatol. 2011; 23(1): 102–107.
    CrossRefPubMed
  26. Maciaszczyk K, Lewiński A. Phenotypes of SLC26A4 gene mutations: Pendred syndrome and hypoacusis with enlarged vestibular aqueduct. Neuro Endocrinol Lett. 2008; 29(1): 29–36.
    PubMed
  27. Chiarella G, Russo D, Monzani F, et al. Hashimoto thyroiditis and vestibular dysfunction. Endocr Pract. 2017; 23(7): 863–868.
    CrossRefPubMed
  28. Sari K, Yildirim T, Borekci H, et al. The relationship between benign paroxysmal positional vertigo and thyroid autoimmunity. Acta Otolaryngol. 2015; 135(8): 754–757.
    CrossRefPubMed
  29. Papi G, Guidetti G, Corsello SM, et al. The association between benign paroxysmal positional vertigo and autoimmune chronic thyroiditis is not related to thyroid status. Thyroid. 2010; 20(2): 237–238.
    CrossRefPubMed
  30. Modugno GC, Pirodda A, Ferri GG, et al. A relationship between autoimmune thyroiditis and benign paroxysmal positional vertigo? Med Hypotheses. 2000; 54(4): 614–615.
    CrossRefPubMed
  31. Chiarella G, Tognini S, Nacci A, et al. Vestibular disorders in euthyroid patients with Hashimoto's thyroiditis: role of thyroid autoimmunity. Clin Endocrinol (Oxf). 2014; 81(4): 600–605.
    CrossRefPubMed
  32. Mazokopakis EE, Kotsiris DA. Hashimoto's autoimmune thyroiditis and vitamin D deficiency. Current aspects. Hell J Nucl Med. 2014; 17(1): 37–40.
    CrossRefPubMed
  33. Mazokopakis EE, Papadomanolaki MG, Tsekouras KC, et al. Is vitamin D related to pathogenesis and treatment of Hashimoto's thyroiditis? Hell J Nucl Med. 2015; 18(3): 222–227.
    PubMed
  34. Chaudhary S, Dutta D, Kumar M, et al. Vitamin D supplementation reduces thyroid peroxidase antibody levels in patients with autoimmune thyroid disease: An open-labeled randomized controlled trial. Indian J Endocrinol Metab. 2016; 20(3): 391–398.
    CrossRefPubMed
  35. Talaat HS, Kabel AMH, Khaliel LH, et al. Reduction of recurrence rate of benign paroxysmal positional vertigo by treatment of severe vitamin D deficiency. Auris Nasus Larynx. 2016; 43(3): 237–241.
    CrossRefPubMed
  36. Talaat HS, Abuhadied G, Talaat AS, et al. Low bone mineral density and vitamin D deficiency in patients with benign positional paroxysmal vertigo. Eur Arch Otorhinolaryngol. 2015; 272(9): 2249–2253.
    CrossRefPubMed
  37. AlGarni MA, Mirza AA, Althobaiti AA, et al. Association of benign paroxysmal positional vertigo with vitamin D deficiency: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol. 2018; 275(11): 2705–2711.
    CrossRefPubMed
  38. Sheikhzadeh M, Lotfi Y, Mousavi A, et al. Influence of supplemental vitamin D on intensity of benign paroxysmal positional vertigo: A longitudinal clinical study. Caspian J Intern Med. 2016; 7(2): 93–98.
    PubMed
  39. Jeong SH, Kim HJ, Kim JS. Vestibular neuritis. Semin Neurol. 2013; 33(3): 185–194.
    CrossRefPubMed
  40. Kim JS, Kim HJ. Inferior vestibular neuritis. J Neurol. 2012; 259(8): 1553–1560.
    CrossRefPubMed
  41. Taylor RL, McGarvie LA, Reid N, et al. Vestibular neuritis affects both superior and inferior vestibular nerves. Neurology. 2016; 87(16): 1704–1712.
    CrossRefPubMed
  42. Büki B, Hanschek M, Jünger H. Vestibular neuritis: Involvement and long-term recovery of individual semicircular canals. Auris Nasus Larynx. 2017; 44(3): 288–293.
    CrossRefPubMed
  43. Girasoli L, Cazzador D, Padoan R, et al. Update on Vertigo in Autoimmune Disorders, from Diagnosis to Treatment. J Immunol Res. 2018; 2018: 5072582.
    CrossRefPubMed
  44. Greco A, Macri GF, Gallo A, et al. Is vestibular neuritis an immune related vestibular neuropathy inducing vertigo? J Immunol Res. 2014; 2014: 459048.
    CrossRefPubMed
  45. Bumm P, Schlimok G. T-lymphocyte subpopulations and HLA-DR antigens in patients with Bell's palsy, hearing loss, neuronitis vestibularis, and Ménière's disease. Eur Arch Otorhinolaryngol. 1994: S447–S448.
    CrossRefPubMed
  46. Brenner M, Hoistad DL, Hain TC. Prevalence of thyroid dysfunction in patients with Ménière's disease. Arch Otolaryngol Head Neck Surg. 2004; 130(2): 226–228.
    CrossRefPubMed
  47. Sun Y, Zhang D, Sun G, et al. RNA-sequencing study of peripheral blood mononuclear cells in sporadic Ménière's disease patients: possible contribution of immunologic dysfunction to the development of this disorder. Clin Exp Immunol. 2018; 192(1): 33–45.
    CrossRefPubMed
  48. Kim SH, Kim JY, Lee HJ, et al. Autoimmunity as a candidate for the etiopathogenesis of Meniere's disease: detection of autoimmune reactions and diagnostic biomarker candidate. PLoS One. 2014; 9(10): e111039.
    CrossRefPubMed
  49. Altermatt HJ, Gebbers JO, Müller C, et al. Human endolymphatic sac: evidence for a role in inner ear immune defence. ORL J Otorhinolaryngol Relat Spec. 1990; 52(3): 143–148.
    CrossRefPubMed
  50. Harris JP, Surgeon S. Choroby ucha wewnętrznego o podłożu immunologicznym. Otorynolaryngologia. 2007; 6(4): 163–178.
  51. Gopen Q, Keithley E, Harris J. Mechanisms underlying autoimmune inner ear disease. Drug Discovery Today: Disease Mechanisms. 2006; 3(1): 137–142.
    CrossRef
  52. Bovo R, Aimoni C, Martini A. Immune-mediated inner ear disease. Acta Otolaryngol. 2006; 126(10): 1012–1021.
    CrossRefPubMed
  53. Ruckenstein MJ. Autoimmune inner ear disease. Curr. Opin. Otolaryngol. Head Neck Surg. 2004; 12: 426–430.
    CrossRefPubMed
  54. Harris JP. Immunology of the inner ear: response of the inner ear to antigen challenge. Otolaryngol Head Neck Surg. 1983; 91(1): 18–32.
    CrossRefPubMed
  55. Solares CA, Edling AE, Johnson JM, et al. Murine autoimmune hearing loss mediated by CD4+ T cells specific for inner ear peptides. J Clin Invest. 2004; 113(8): 1210–1217.
    CrossRefPubMed
  56. Arnold W, Altermatt HJ, Gebbers JO. [Qualitative detection of immunoglobulins in the human endolymphatic sac]. Laryngol Rhinol Otol (Stuttg). 1984; 63(9): 464–467.
    PubMed
  57. Rask-Andersen H, Stahle J. Immunodefence of the inner ear? Lymphocyte-macrophage interaction in the endolymphatic sac. Acta Otolaryngol. 1980; 89(3-4): 283–294.
    CrossRefPubMed
  58. Nacci A, Dallan I, Monzani F, et al. Elevated antithyroid peroxidase and antinuclear autoantibody titers in Ménière's disease patients: more than a chance association? Audiol Neurootol. 2010; 15(1): 1–6.
    CrossRefPubMed
  59. Fattori B, Nacci A, Dardano A, et al. Possible association between thyroid autoimmunity and Menière's disease. Clin Exp Immunol. 2008; 152(1): 28–32.
    CrossRefPubMed
  60. Santosh UP, Rao MS. Incidence of Hypothyroidism in Meniere's Disease. J Clin Diagn Res. 2016; 10(5): MC01–MC03.
    CrossRefPubMed
  61. Zamysłowska-Szmytke E, Śliwińska-Kowalska M. Opracowanie wartości normatywnych testów kinetycznych w badaniu wideonystagmografii (VNG). Medycyna Pr. 2011; 63(3): 237–246.
    PubMed
  62. Redondo-Martínez J, Bécares-Martínez C, Orts-Alborch M, et al. Relationship between video head impulse test (vHIT) and caloric test in patients with vestibular neuritis. Acta Otorrinolaringol Esp. 2016; 67(3): 156–161.
    CrossRefPubMed
  63. Janky KL, Patterson J, Shepard N, et al. Video Head Impulse Test (vHIT): The Role of Corrective Saccades in Identifying Patients With Vestibular Loss. Otol Neurotol. 2018; 39(4): 467–473.
    CrossRefPubMed
  64. van de Berg R, Rosengren S, Kingma H. Laboratory examinations for the vestibular system. Curr Opin Neurol. 2018; 31(1): 111–116.
    CrossRefPubMed
  65. Blödow A, Heinze M, Bloching MB, et al. Caloric stimulation and video-head impulse testing in Ménière's disease and vestibular migraine. Acta Otolaryngol. 2014; 134(12): 1239–1244.
    CrossRefPubMed
  66. Burston A, Mossman S, Mossman B, et al. Comparison of the video head impulse test with the caloric test in patients with sub-acute and chronic vestibular disorders. J Clin Neurosci. 2018; 47: 294–298.
    CrossRefPubMed
  67. Johnson SA, O'Beirne GA, Lin E, et al. oVEMPs and cVEMPs in patients with 'clinically certain' Menière's disease. Acta Otolaryngol. 2016; 136(10): 1029–1034.
    CrossRefPubMed
  68. Fife TD, Colebatch JG, Kerber KA, et al. Practice guideline: Cervical and ocular vestibular evoked myogenic potential testing: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology. 2017; 89(22): 2288–2296.
    CrossRefPubMed
  69. Hamid MA. Determining side of vestibular dysfunction with rotatory chair testing. Otolaryngol Head Neck Surg. 1991; 105(1): 40–43.
    CrossRefPubMed
  70. Perez N, Martin E, Romero MD, et al. Influence of canal paresis and compensation on gain and time constant of nystagmus slow-phase velocity to yaw-axis rotation. Acta Otolaryngol. 2001; 121(6): 715–723.
    CrossRefPubMed
  71. Arriaga MA, Chen DA, Cenci KA. Rotational chair (ROTO) instead of electronystagmography (ENG) as the primary vestibular test. Otolaryngol Head Neck Surg. 2005; 133(3): 329–333.
    CrossRefPubMed
  72. Strupp M, Kim JS, Murofushi T, et al. Bilateral vestibulopathy: Diagnostic criteria Consensus document of the Classification Committee of the Bárány Society. J Vestib Res. 2017; 27(4): 177–189.
    CrossRefPubMed
  73. Honaker JA, Janky KL, Patterson JN, et al. Modified head shake sensory organization test: Sensitivity and specificity. Gait Posture. 2016; 49: 67–72.
    CrossRefPubMed
  74. Hebert JR, Manago MM. Reliability and Validity of the Computerized Dynamic Posturography Sensory Organization Test in People with Multiple Sclerosis. Int J MS Care. 2017; 19(3): 151–157.
    CrossRefPubMed
  75. Daneshi A, Bozorgzadeh N, Asghari A, et al. Dynamic posturography for staging of patients with Ménière's disease. J Laryngol Otol. 2009; 123(8): 863–867.
    CrossRefPubMed
  76. Morisod B, Mermod M, Maire R. Posturographic pattern of patients with chronic subjective dizziness before and after vestibular rehabilitation. J Vestib Res. 2018; 27(5-6): 305–311.
    CrossRefPubMed
  77. Di Fabio RP. Sensitivity and specificity of platform posturography for identifying patients with vestibular dysfunction. Phys Ther. 1995; 75(4): 290–305.
    CrossRefPubMed

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Via MedicaWydawcą jest  VM Media Group sp. z o.o., Grupa Via Medica, ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl