open access

Vol 71, No 1 (2020)
Original Paper
Published online: 2020-01-07
Submitted: 2019-09-04
Accepted: 2019-10-23
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Association of single nucleotide polymorphism (rs741301) of the ELMO1 gene with diabetic kidney disease in Polish patients with type 2 diabetes: a pilot study

Hanna Kwiendacz, Katarzyna Nabrdalik, Piotr Adamczyk, Dariusz Moczulski, Hanna Moczulska, Wanda Trautsolt, Sylwia Górczyńska-Kosiorz, Władysław Grzeszczak, Janusz Gumprecht
DOI: 10.5603/EP.a2019.0066
·
Pubmed: 31909452
·
Endokrynologia Polska 2020;71(1):66-72.

open access

Vol 71, No 1 (2020)
Original Paper
Published online: 2020-01-07
Submitted: 2019-09-04
Accepted: 2019-10-23

Abstract

Introduction: Multifactorial pathogenesis of diabetic kidney disease (DKD) consists of a combination of metabolic, environmental, and genetic factors. A genome-wide association study has shown that ELMO1 is a candidate gene for DKD occurrence and progression. The aim of this study was to assess the association of a single nucleotide polymorphism (rs741301) of the ELMO1 gene with DKD in Polish patients with type 2 diabetes (T2DM).

Material and methods: This was a case/control study of 272 T2DM patients with or without DKD. Patients were divided into groups depending on DKD definition according to the American Diabetes Association (ADA) and the National Kidney Foundation (NKF). The association of the rs741301 polymorphism with DKD was assessed in the whole study group as well as in the subgroups stratified according to the presence of DKD.

Results: There was no association between rs741301 polymorphisms and the presence of DKD in relation to the ADA definition (p = 0.6) or the NKF definition (p = 0.5) of DKD and with estimated glomelural filtration rate (eGFR) value reflecting the stage of the chronic kidney disease (p = 0.8).

Conclusions: Even though the results of this study are negative, there is still a great need for larger studies assessing the genetic susceptibility to DKD to identify patients who are particularly prone to this complication.

Abstract

Introduction: Multifactorial pathogenesis of diabetic kidney disease (DKD) consists of a combination of metabolic, environmental, and genetic factors. A genome-wide association study has shown that ELMO1 is a candidate gene for DKD occurrence and progression. The aim of this study was to assess the association of a single nucleotide polymorphism (rs741301) of the ELMO1 gene with DKD in Polish patients with type 2 diabetes (T2DM).

Material and methods: This was a case/control study of 272 T2DM patients with or without DKD. Patients were divided into groups depending on DKD definition according to the American Diabetes Association (ADA) and the National Kidney Foundation (NKF). The association of the rs741301 polymorphism with DKD was assessed in the whole study group as well as in the subgroups stratified according to the presence of DKD.

Results: There was no association between rs741301 polymorphisms and the presence of DKD in relation to the ADA definition (p = 0.6) or the NKF definition (p = 0.5) of DKD and with estimated glomelural filtration rate (eGFR) value reflecting the stage of the chronic kidney disease (p = 0.8).

Conclusions: Even though the results of this study are negative, there is still a great need for larger studies assessing the genetic susceptibility to DKD to identify patients who are particularly prone to this complication.

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Keywords

diabetes mellitus type 2; diabetic kidney disease; ELMO1 gene; rs741301; SNP

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About this article
Title

Association of single nucleotide polymorphism (rs741301) of the ELMO1 gene with diabetic kidney disease in Polish patients with type 2 diabetes: a pilot study

Journal

Endokrynologia Polska

Issue

Vol 71, No 1 (2020)

Pages

66-72

Published online

2020-01-07

DOI

10.5603/EP.a2019.0066

Pubmed

31909452

Bibliographic record

Endokrynologia Polska 2020;71(1):66-72.

Keywords

diabetes mellitus type 2
diabetic kidney disease
ELMO1 gene
rs741301
SNP

Authors

Hanna Kwiendacz
Katarzyna Nabrdalik
Piotr Adamczyk
Dariusz Moczulski
Hanna Moczulska
Wanda Trautsolt
Sylwia Górczyńska-Kosiorz
Władysław Grzeszczak
Janusz Gumprecht

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