open access

Vol 71, No 1 (2020)
Short communications
Published online: 2019-11-04
Submitted: 2019-08-26
Accepted: 2019-10-14
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Hypothyroidism is associated with higher testosterone levels in postmenopausal women with Hashimoto's thyroiditis

Katica Bajuk Studen, Ajda Biček, Adrijana Oblak, Katja Zaletel, Simona Gaberšček
DOI: 10.5603/EP.a2019.0055
·
Pubmed: 31681972
·
Endokrynologia Polska 2020;71(1):73-75.

open access

Vol 71, No 1 (2020)
Short communications
Published online: 2019-11-04
Submitted: 2019-08-26
Accepted: 2019-10-14

Abstract

Introduction: There are few data about possible interaction of sex hormones and thyroid autoimmunity and function in women with Hashimoto’s thyroiditis (HT) after menopause. Therefore, our aim was to investigate sex hormone levels in euthyroid (EuHT) and hypothyroid (HypoHT) postmenopausal women with HT.

Material and methods: We performed a prospective observational clinical study that included 55 women with HT (AllHT) and 18 healthy subjects (HS) after menopause matched by age, body mass index, follicle-stimulating hormone, and menopause duration. According to their thyrotropin (TSH) level, the AllHT patients were divided into two subgroups: EuHT with TSH in the range 0.35–5.5 mU/L and HypoHT with TSH above 5.5 mU/L. Total and free testosterone (T), sex hormone-binding globulin (SHBG), oestradiol (E2), and progesterone (P) were measured in all subjects. Values are presented as mean ± SD. The Mann-Whitney U test was used for comparison of values between the groups. Correlations were tested using Kendall’s tau test.

Results: In the HypoHT group, significantly higher free T levels were found in comparison to the HS group (7.89 ± 3.55 pmol/L and 7.13 ± 3.03 pmol/L, p < 0.05). Furthermore, in HypoHT, free T was significantly higher than in EuHT (7.19 ± 5.65 pmol/L, p < 0.05). SHBG was significantly lower in HypoHT compared with HS (45.4 ± 17.4 nmol/L and 60.09 ± 19.51 nmol/L, p < 0.05). No significant correlation was found between sex hormone levels and thyroglobulin and thyroid peroxidase antibodies.

Conclusion: We report significantly higher free and total T levels in hypothyroid postmenopausal women with HT. To our knowledge, this is the first study of sex hormone levels in postmenopausal women with HT. 

Abstract

Introduction: There are few data about possible interaction of sex hormones and thyroid autoimmunity and function in women with Hashimoto’s thyroiditis (HT) after menopause. Therefore, our aim was to investigate sex hormone levels in euthyroid (EuHT) and hypothyroid (HypoHT) postmenopausal women with HT.

Material and methods: We performed a prospective observational clinical study that included 55 women with HT (AllHT) and 18 healthy subjects (HS) after menopause matched by age, body mass index, follicle-stimulating hormone, and menopause duration. According to their thyrotropin (TSH) level, the AllHT patients were divided into two subgroups: EuHT with TSH in the range 0.35–5.5 mU/L and HypoHT with TSH above 5.5 mU/L. Total and free testosterone (T), sex hormone-binding globulin (SHBG), oestradiol (E2), and progesterone (P) were measured in all subjects. Values are presented as mean ± SD. The Mann-Whitney U test was used for comparison of values between the groups. Correlations were tested using Kendall’s tau test.

Results: In the HypoHT group, significantly higher free T levels were found in comparison to the HS group (7.89 ± 3.55 pmol/L and 7.13 ± 3.03 pmol/L, p < 0.05). Furthermore, in HypoHT, free T was significantly higher than in EuHT (7.19 ± 5.65 pmol/L, p < 0.05). SHBG was significantly lower in HypoHT compared with HS (45.4 ± 17.4 nmol/L and 60.09 ± 19.51 nmol/L, p < 0.05). No significant correlation was found between sex hormone levels and thyroglobulin and thyroid peroxidase antibodies.

Conclusion: We report significantly higher free and total T levels in hypothyroid postmenopausal women with HT. To our knowledge, this is the first study of sex hormone levels in postmenopausal women with HT. 

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Keywords

Hashimoto’s thyroiditis; testosterone; menopause; hypothyroidism

About this article
Title

Hypothyroidism is associated with higher testosterone levels in postmenopausal women with Hashimoto's thyroiditis

Journal

Endokrynologia Polska

Issue

Vol 71, No 1 (2020)

Pages

73-75

Published online

2019-11-04

DOI

10.5603/EP.a2019.0055

Pubmed

31681972

Bibliographic record

Endokrynologia Polska 2020;71(1):73-75.

Keywords

Hashimoto’s thyroiditis
testosterone
menopause
hypothyroidism

Authors

Katica Bajuk Studen
Ajda Biček
Adrijana Oblak
Katja Zaletel
Simona Gaberšček

References (5)
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  2. Mariotti S, Prinzis A, Ghiani M, et al. Puberty is associated with a marked increase of the female sex predominance in chronic autoimmune thyroiditis. Horm Res. 2009; 72(1): 52–56.
  3. Janssen OE, Mehlmauer N, Hahn S, et al. High prevalence of autoimmune thyroiditis in patients with polycystic ovary syndrome. Eur J Endocrinol. 2004; 150(3): 363–369.
  4. Bove R. Autoimmune diseases and reproductive aging. Clin Immunol. 2013; 149(2): 251–264.
  5. Krassas GE, Poppe K, Glinoer D. Thyroid function and human reproductive health. Endocr Rev. 2010; 31(5): 702–755.

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