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Liver transplantation as an option of treatment for a giant primary hepatic neuroendocrine tumour
, 1, 2, 3, 2, 1
Affiliations- Department of General, Vascular and Transplant Surgery, Medical University of Silesia, Katowice, Poland
- Department of Endocrinology and Neuroendocrine Tumours, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland
- Nuclear Medicine Department, Medical University of Warsaw, Warsaw, Poland
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Abstract
There are no clear guidelines for the treatment of hepatic neuroendocrine tumours. Surgical resections — though rarely radical — seem to be the treatment of choice. Thermoablation, chemoembolisation, or cytoreductive surgery of hepatic focal lesions are often recommended.
Pharmacological treatment is based on somatostatin analogues. Liver transplantation is available for a strictly selected group of patients with hepatic neuroendocrine tumours [5]. In the case described above, there were a number of factors that affected the decision about eligibility: first of all — very slow growth of the tumour, its size, and typical multifocality, which made it impossible to perform resection, lack of neoplastic focus outside the liver, and low Ki-67 proliferation index of ≤ 2%. The surgical risk was escalated due to the giant tumour mass and the laparotomy, which was performed twice.
Abstract
There are no clear guidelines for the treatment of hepatic neuroendocrine tumours. Surgical resections — though rarely radical — seem to be the treatment of choice. Thermoablation, chemoembolisation, or cytoreductive surgery of hepatic focal lesions are often recommended.
Pharmacological treatment is based on somatostatin analogues. Liver transplantation is available for a strictly selected group of patients with hepatic neuroendocrine tumours [5]. In the case described above, there were a number of factors that affected the decision about eligibility: first of all — very slow growth of the tumour, its size, and typical multifocality, which made it impossible to perform resection, lack of neoplastic focus outside the liver, and low Ki-67 proliferation index of ≤ 2%. The surgical risk was escalated due to the giant tumour mass and the laparotomy, which was performed twice.
Keywords
neuroendocrine tumour; liver transplantation
About this articleTitle
Liver transplantation as an option of treatment for a giant primary hepatic neuroendocrine tumour
Journal
Issue
Article type
Clinical vignette
Pages
520-521
Published online
2019-11-19
Page views
1172
Article views/downloads
707
DOI
Pubmed
Bibliographic record
Endokrynol Pol 2019;70(6):520-521.
Keywords
neuroendocrine tumour
liver transplantation
Authors
Grzegorz Oczkowicz
Artur Caban
Anna Zemczak
Jolanta Kunikowska
Beata Kos-Kudła
Robert Król
References (5)- Scheuer P. Tumors of the Liver and Intrahepatic Bile Ducts. J Clin Pathol. 1990; 43(9): 786–786.
- Song JE, Kim BS, Lee CH. Primary hepatic neuroendocrine tumor: A case report and literature review. World J Clin Cases. 2016; 4(8): 243–247.
- Cha DIk, Kang TW, Jang KM, et al. Hepatic neuroendocrine tumors: gadoxetic acid-enhanced magnetic resonance imaging findings with an emphasis on differentiation between primary and secondary tumors. Abdom Radiol (NY). 2018; 43(12): 3331–3339.
- Zhao ZM, Wang J, Ugwuowo UC, et al. Primary hepatic neuroendocrine carcinoma: report of two cases and literature review. BMC Clin Pathol. 2018; 18: 3.
- Bonaccorsi-Riani E, Apestegui C, Jouret-Mourin A, et al. Liver transplantation and neuroendocrine tumors: lessons from a single centre experience and from the literature review. Transpl Int. 2010; 23(7): 668–678.
