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The role of adipokines in the pathogenesis and course of selected respiratory diseases
Affiliations- Pulmonology Branch Unit, Pulmonary Rehabilitation Independent Public Clinical Hospital No. 1, Silesian Medical University in Katowice, Zabrze, Poland
open access
Abstract
Adipose tissue is also a secretory organ producing active substances called adipokines. Some of them (apelin, resistin, adiponectin, leptin, chemerin, or visfatin) may play a role in the pathogenesis and course of respiratory diseases, e.g. COPD, asthma, pulmonary hypertension, or lung cancer. There are limited and conflicting data on the role of adipokines in asthma. It has been confirmed, however, that visfatin and leptin can be markers of inflammation in COPD. Elevated concentrations of leptin and resistin play a pro-inflammatory role in the development of cancer cachexia. The role of adipokines has also been demonstrated in pulmonary hypertension, and the apelinadiponectin axis disruption may exacerbate pulmonary hypertension.
Abstract
Adipose tissue is also a secretory organ producing active substances called adipokines. Some of them (apelin, resistin, adiponectin, leptin, chemerin, or visfatin) may play a role in the pathogenesis and course of respiratory diseases, e.g. COPD, asthma, pulmonary hypertension, or lung cancer. There are limited and conflicting data on the role of adipokines in asthma. It has been confirmed, however, that visfatin and leptin can be markers of inflammation in COPD. Elevated concentrations of leptin and resistin play a pro-inflammatory role in the development of cancer cachexia. The role of adipokines has also been demonstrated in pulmonary hypertension, and the apelinadiponectin axis disruption may exacerbate pulmonary hypertension.
Keywords
adipokines; apelin; resistin; adiponectin; leptin; chemerin; visfatin; nesfatin; COPD; pulmonary hypertension; non-small cell lung cancer
About this articleTitle
The role of adipokines in the pathogenesis and course of selected respiratory diseases
Journal
Issue
Article type
Review paper
Pages
504-510
Published online
2019-12-20
Page views
2734
Article views/downloads
1891
DOI
Pubmed
Bibliographic record
Endokrynol Pol 2019;70(6):504-510.
Keywords
adipokines
apelin
resistin
adiponectin
leptin
chemerin
visfatin
nesfatin
COPD
pulmonary hypertension
non-small cell lung cancer
Authors
Artur Chwalba
Edyta Machura
Katarzyna Ziora
Dariusz Ziora
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