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BRAF V600E mutation in papillary thyroid cancer is correlated with adverse clinicopathological features but not with iodine exposure
Affiliations- Endocrinology and Metabolism Section, Haydarpaşa Education and Training Hospital, Istanbul, Turkey
- Department of Molecular Biology & Genetics, Arts and Sciences Faculty, Namık Kemal University, Tekirdağ, Türkiye
- Department of Pathology, Kartal Dr. Lütfi Kırdar Education and Training Hospital, Istanbul, Turkey
- Department of Medical Oncology, Kartal Dr. Lütfi Kırdar Education and Training Hospital, Istanbul, Turkey
- Department of Endocrinology and Metabolism, Marmara University, School of Medicine, Istanbul, Turkey
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Abstract
Introduction: BRAFV600E activating mutation is the most frequent genetic abnormality in the pathogenesis of papillary thyroid carcinoma. We aimed to evaluate the association between BRAFV600E mutation and well-established prognostic clinicopathological characteristics as well as iodine exposure.
Material and methods: From 2000 to 2012, the data of PTC patients admitted to Dr. Lutfi Kirdar Kartal Education and Research Hospital in Turkey were reviewed retrospectively. Clinicopathological parameters were collected. BRAFV600E mutation was analysed by DNA sequencing method in tumour specimens. We hypothesised that BRAFV600E mutation prevalence is positively correlated with prolonged iodine exposure and expected to be higher in the second half of the recruitment period due to the increment in time spent from the iodisation process of the table salt in our country. Thus, iodine exposure was categorised as short-term (2000–2006) and long-term (2006–2012).
Results: A total of 197 patients were accrued. The study population predominantly consisted of conventional variant. A statistically significant relationship was observed between BRAFV600E mutation presence and age (p = 0.03), conventional variant PTC (p = 0.00002), T4 stage (p = 0.002), vascular invasion (p = 0.036), thyroid capsule invasion (p < 0.00001), extrathyroidal tissue invasion (p < 0.00001), and lymph node metastasis (p < 0.00001). When categorised as long-term and short-term, iodine exposure was not statistically significantly related with BRAFV600E mutation; however, there were far more PTC cases in the long-term group (86.3% vs. 13.7%).
Conclusion: We revealed that BRAFV600E mutation is associated with adverse clinicopathological parameters. There appeared to be no relation between long-term iodine exposure and BRAFV600E.
Abstract
Introduction: BRAFV600E activating mutation is the most frequent genetic abnormality in the pathogenesis of papillary thyroid carcinoma. We aimed to evaluate the association between BRAFV600E mutation and well-established prognostic clinicopathological characteristics as well as iodine exposure.
Material and methods: From 2000 to 2012, the data of PTC patients admitted to Dr. Lutfi Kirdar Kartal Education and Research Hospital in Turkey were reviewed retrospectively. Clinicopathological parameters were collected. BRAFV600E mutation was analysed by DNA sequencing method in tumour specimens. We hypothesised that BRAFV600E mutation prevalence is positively correlated with prolonged iodine exposure and expected to be higher in the second half of the recruitment period due to the increment in time spent from the iodisation process of the table salt in our country. Thus, iodine exposure was categorised as short-term (2000–2006) and long-term (2006–2012).
Results: A total of 197 patients were accrued. The study population predominantly consisted of conventional variant. A statistically significant relationship was observed between BRAFV600E mutation presence and age (p = 0.03), conventional variant PTC (p = 0.00002), T4 stage (p = 0.002), vascular invasion (p = 0.036), thyroid capsule invasion (p < 0.00001), extrathyroidal tissue invasion (p < 0.00001), and lymph node metastasis (p < 0.00001). When categorised as long-term and short-term, iodine exposure was not statistically significantly related with BRAFV600E mutation; however, there were far more PTC cases in the long-term group (86.3% vs. 13.7%).
Conclusion: We revealed that BRAFV600E mutation is associated with adverse clinicopathological parameters. There appeared to be no relation between long-term iodine exposure and BRAFV600E.
Keywords
papillary thyroid cancer; BRAF V600E; iodine
About this articleTitle
BRAF V600E mutation in papillary thyroid cancer is correlated with adverse clinicopathological features but not with iodine exposure
Journal
Issue
Article type
Original paper
Pages
401-408
Published online
2019-05-27
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1539
Article views/downloads
914
DOI
Pubmed
Bibliographic record
Endokrynol Pol 2019;70(5):401-408.
Keywords
papillary thyroid cancer
BRAF V600E
iodine
Authors
Serhat Özçelik
Rifat Bircan
Şükran Sarıkaya
Aylin Ege Gül
Büşra Aydın
Melike Özçelik
Mehmet Çelik
Akın Dayan
Yasemin Tütüncü
Hasret Cengiz
Nimet Karadayı
Hülya Ilıksu Gözü
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