Vol 69, No 6 (2018)
Review paper
Published online: 2018-10-01

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Klotho protein function among patients with type 1 diabetes

Justyna Flotyńska1, Aleksandra Uruska1, Aleksandra Araszkiewicz1, Dorota Zozulińska-Ziółkiewicz1
Pubmed: 30620382
Endokrynol Pol 2018;69(6):696-704.


The fibroblast growth factor 23 (FGF23) and Klotho system play a very important role in the regulation of the human body metabolism. On the one hand, they promote longevity, and on the other hand they promote insulin resistance. Nowadays, accelerated aging in diabetes as the main consequence of chronic complications of the disease is postulated. Signalling pathways induced by insulin, insulin-like growth factor (IGF-1), and their homologues play an important role in controlling the aging process. Because FGF23/Klotho system affects glucose metabolism and gene expression of antioxidant enzymes, changes in its concentration may be a marker of chronic complications of diabetes or a treatment option. Despite huge improvements in the treatment of diabetes, its chronic complications remain an important clinical problem. An interesting issue is the relationship between the concentration of FGF23/Klotho and management of the disease, duration, insulin resistance, and development of complications in type 1 diabetes.

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