open access

Vol 69, No 6 (2018)
Original paper
Submitted: 2018-05-02
Accepted: 2018-06-07
Published online: 2018-09-25
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The effect of short-term perindopril and telmisartan treatment on circulating levels of anti-inflammatory cytokines in hypertensive patients

Wojciech Gilowski1, Robert Krysiak2, Bogdan Marek34, Bogusław Okopień2
·
Pubmed: 30259507
·
Endokrynol Pol 2018;69(6):667-674.
Affiliations
  1. Cardiology Department, Chrzanów District Hospital, Chrzanów, Poland
  2. Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland
  3. Division of Pathophysiology, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Zabrze, Poland
  4. Endocrinological Ward, Third Provincial Hospital, Rybnik, Poland

open access

Vol 69, No 6 (2018)
Original Paper
Submitted: 2018-05-02
Accepted: 2018-06-07
Published online: 2018-09-25

Abstract

Introduction: Both angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers were found to reduce plasma levels of proinflammatory cytokines. No previous study has compared their effect on the production of anti-inflammatory cytokines.
Material and methods: The study enrolled 52 patients with grade 1 and grade 2 arterial hypertension. The participants were divided into two groups treated with either perindopril (4 mg daily) or telmisartan (40 mg daily). Blood pressure, plasma lipids, glucose homeostasis markers, as well as plasma levels of uric acid, interleukins 4, 10, 13 (IL-4, IL-10, IL-13), and high sensitivity C-reactive protein (hsCRP)
were measured at the beginning of the study and six weeks later.
Results: Both perindopril and telmisartan reduced systolic (SBP) and diastolic blood pressure (DBP). Although both agents increased serum levels of IL-10, this effect was more pronounced in patients treated with telmisartan. Neither telmisartan nor perindopril affected circulating levels of uric acid, glucose, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, IL-4, IL-13, and hsCRP. The effect of telmisartan on IL-10 slightly correlated with an improvement in insulin sensitivity. Treatment-induced changes in IL-10 did not correlate
with hypotensive properties of perindopril and telmisartan.
Conclusions: The obtained results indicate that angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers administered for a short period of time produce a relatively week effect on anti-inflammatory cytokines, limited to IL-10, and stronger for telmisartan than for perindopril.

Abstract

Introduction: Both angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers were found to reduce plasma levels of proinflammatory cytokines. No previous study has compared their effect on the production of anti-inflammatory cytokines.
Material and methods: The study enrolled 52 patients with grade 1 and grade 2 arterial hypertension. The participants were divided into two groups treated with either perindopril (4 mg daily) or telmisartan (40 mg daily). Blood pressure, plasma lipids, glucose homeostasis markers, as well as plasma levels of uric acid, interleukins 4, 10, 13 (IL-4, IL-10, IL-13), and high sensitivity C-reactive protein (hsCRP)
were measured at the beginning of the study and six weeks later.
Results: Both perindopril and telmisartan reduced systolic (SBP) and diastolic blood pressure (DBP). Although both agents increased serum levels of IL-10, this effect was more pronounced in patients treated with telmisartan. Neither telmisartan nor perindopril affected circulating levels of uric acid, glucose, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, IL-4, IL-13, and hsCRP. The effect of telmisartan on IL-10 slightly correlated with an improvement in insulin sensitivity. Treatment-induced changes in IL-10 did not correlate
with hypotensive properties of perindopril and telmisartan.
Conclusions: The obtained results indicate that angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers administered for a short period of time produce a relatively week effect on anti-inflammatory cytokines, limited to IL-10, and stronger for telmisartan than for perindopril.

Get Citation

Keywords

 anti-inflammatory cytokines; angiotensin-converting enzyme inhibitors; angiotensin II receptor blockers; arterial hypertension; low-grade systemic inflammation

About this article
Title

The effect of short-term perindopril and telmisartan treatment on circulating levels of anti-inflammatory cytokines in hypertensive patients

Journal

Endokrynologia Polska

Issue

Vol 69, No 6 (2018)

Article type

Original paper

Pages

667-674

Published online

2018-09-25

Page views

2919

Article views/downloads

1189

DOI

10.5603/EP.a2018.0068

Pubmed

30259507

Bibliographic record

Endokrynol Pol 2018;69(6):667-674.

Keywords

 anti-inflammatory cytokines
angiotensin-converting enzyme inhibitors
angiotensin II receptor blockers
arterial hypertension
low-grade systemic inflammation

Authors

Wojciech Gilowski
Robert Krysiak
Bogdan Marek
Bogusław Okopień

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