open access

Vol 70, No 1 (2019)
Original papers
Published online: 2018-09-24
Submitted: 2018-03-26
Accepted: 2018-06-14
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The association between serum metalloproteinase concentration, obesity, and hormone levels in reproductive-aged women

Barbara Grzechocińska, Filip A. Dąbrowski, Janusz Sierdzinski, Anna Cyganek, Mirosław Wielgoś
DOI: 10.5603/EP.a2018.0067
·
Pubmed: 30259506
·
Endokrynologia Polska 2019;70(1):49-56.

open access

Vol 70, No 1 (2019)
Original papers
Published online: 2018-09-24
Submitted: 2018-03-26
Accepted: 2018-06-14

Abstract

Introduction: Increased levels and activity of some matrix metalloproteinases (MMPs) are described in obesity-related vascular diseases. Factors that influence MMP blood concentration are still being investigated. This research aims to evaluate the concentration of most types of MMPs: collagenases (MMP-1, -3, -8, -13), matrilysin (MMP-7), gelatinase (MMP-9), and metalloelastase (MMP-12) in serum of women in reproductive age in relation with their body mass index (BMI), age, oestradiol, and progesterone concentrations. Material and methods: Blood samples were taken from 54 healthy reproductive-aged women with normal menstrual cycles. The weight and height of all women were measured, and body mass index (BMI) was calculated. Concentration of MMP-1, -3, -7, -8, -9, -12, and MMP-13 was evaluated using a Procarta Immunoassay Kit. Serum concentrations of oestradiol and progesterone were evaluated by immunochemiluminescence (32 in the proliferative and 20 in the secretory phase of menstrual cycle). The results of the study were statistically calculated using Pearson, Spearman, and Kruskal-Wallis tests. Results: Positive correlation between MMP-7, -8, -9, -12, and -13 levels and BMI was demonstrated. Significantly higher concentrations of MMPs were found especially in obese women compared to women with normal BMI. In healthy, regularly menstruating premenopausal women, MMP levels did not correlate with oestradiol and progesterone concentrations. Conclusions: The results suggest that body mass can influence MMP serum concentration in women with regular menstrual cycles.

Abstract

Introduction: Increased levels and activity of some matrix metalloproteinases (MMPs) are described in obesity-related vascular diseases. Factors that influence MMP blood concentration are still being investigated. This research aims to evaluate the concentration of most types of MMPs: collagenases (MMP-1, -3, -8, -13), matrilysin (MMP-7), gelatinase (MMP-9), and metalloelastase (MMP-12) in serum of women in reproductive age in relation with their body mass index (BMI), age, oestradiol, and progesterone concentrations. Material and methods: Blood samples were taken from 54 healthy reproductive-aged women with normal menstrual cycles. The weight and height of all women were measured, and body mass index (BMI) was calculated. Concentration of MMP-1, -3, -7, -8, -9, -12, and MMP-13 was evaluated using a Procarta Immunoassay Kit. Serum concentrations of oestradiol and progesterone were evaluated by immunochemiluminescence (32 in the proliferative and 20 in the secretory phase of menstrual cycle). The results of the study were statistically calculated using Pearson, Spearman, and Kruskal-Wallis tests. Results: Positive correlation between MMP-7, -8, -9, -12, and -13 levels and BMI was demonstrated. Significantly higher concentrations of MMPs were found especially in obese women compared to women with normal BMI. In healthy, regularly menstruating premenopausal women, MMP levels did not correlate with oestradiol and progesterone concentrations. Conclusions: The results suggest that body mass can influence MMP serum concentration in women with regular menstrual cycles.

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Keywords

MMP; obesity; cardiovascular risk; oestradiol; progesterone

About this article
Title

The association between serum metalloproteinase concentration, obesity, and hormone levels in reproductive-aged women

Journal

Endokrynologia Polska

Issue

Vol 70, No 1 (2019)

Pages

49-56

Published online

2018-09-24

DOI

10.5603/EP.a2018.0067

Pubmed

30259506

Bibliographic record

Endokrynologia Polska 2019;70(1):49-56.

Keywords

MMP
obesity
cardiovascular risk
oestradiol
progesterone

Authors

Barbara Grzechocińska
Filip A. Dąbrowski
Janusz Sierdzinski
Anna Cyganek
Mirosław Wielgoś

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