open access

Vol 69, No 4 (2018)
Case report
Published online: 2018-06-29
Submitted: 2017-04-11
Accepted: 2017-05-11
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Foetal goitrous hypothyroidism — easy to recognise, difficult to treat. Is combined intra-amniotic and intravenous L-thyroxine therapy an option?

Marzena Dębska, Małgorzata Gietka-Czernel, Piotr Kretowicz, Dagmara Filipecka-Tyczka, Łukasz Lewczuk, Joanna Dangel, Romuald Dębski
DOI: 10.5603/EP.a2018.0045
·
Pubmed: 29956299
·
Endokrynologia Polska 2018;69(4):442-446.

open access

Vol 69, No 4 (2018)
Case report
Published online: 2018-06-29
Submitted: 2017-04-11
Accepted: 2017-05-11

Abstract

Introduction: Foetal hypothyroidism negatively impacts somatic and neurological child development and can be the cause of serious obstetric and perinatal complications. We present a rare case of a large foetal dyshormonogenetic goitre, causing foetal neck hyperexten­sion, oesophageal compression, and cardiac high-output failure.

Material and methods: A foetal goitre complicated by cardiomegaly and polyhydramnios was diagnosed at 23 weeks of gestation (WG) on a routine ultrasonographic (US) assessment in a healthy nullipara. Foetal blood sampling was performed and a severe foetal hypothyroid­ism was diagnosed. Treatment was undertaken with an intra-amniotic followed by combined intra-amniotic and intravenous injections of L-thyroxine (L–T4). A total of 11 doses of L–T4 were administered between 24–37 WG to the foetus.

Results: A complete regression of foetal goitre, cardiomegaly, and polyhydramnios was observed. At 38 WG the patient delivered vagi­nally a male infant with mild hypothyroidism and no signs of goitre or cardiomegaly on postnatal US. Neurological development of the one year old baby is normal.

Conclusions: The effective diminishing of serum TSH concentration and goitre size was reached after combined intra-amniotic and in­travenous L–T4 injections were given. L–T4 requirement in the foetus is equal to or above 15 μg/kg daily and should be given in weekly intervals due to its rapid metabolism by the foetus and by placental type 3 deiodinase. Intra-amniotic L–T4 administration may be inef­fective when a large goitre indisposes amniotic fluid swallowing by the foetus, so then the combined L–T4 injections into the umbilical vein and intra-amniotically in experienced hands seems to be a reasonable and effective option.

Abstract

Introduction: Foetal hypothyroidism negatively impacts somatic and neurological child development and can be the cause of serious obstetric and perinatal complications. We present a rare case of a large foetal dyshormonogenetic goitre, causing foetal neck hyperexten­sion, oesophageal compression, and cardiac high-output failure.

Material and methods: A foetal goitre complicated by cardiomegaly and polyhydramnios was diagnosed at 23 weeks of gestation (WG) on a routine ultrasonographic (US) assessment in a healthy nullipara. Foetal blood sampling was performed and a severe foetal hypothyroid­ism was diagnosed. Treatment was undertaken with an intra-amniotic followed by combined intra-amniotic and intravenous injections of L-thyroxine (L–T4). A total of 11 doses of L–T4 were administered between 24–37 WG to the foetus.

Results: A complete regression of foetal goitre, cardiomegaly, and polyhydramnios was observed. At 38 WG the patient delivered vagi­nally a male infant with mild hypothyroidism and no signs of goitre or cardiomegaly on postnatal US. Neurological development of the one year old baby is normal.

Conclusions: The effective diminishing of serum TSH concentration and goitre size was reached after combined intra-amniotic and in­travenous L–T4 injections were given. L–T4 requirement in the foetus is equal to or above 15 μg/kg daily and should be given in weekly intervals due to its rapid metabolism by the foetus and by placental type 3 deiodinase. Intra-amniotic L–T4 administration may be inef­fective when a large goitre indisposes amniotic fluid swallowing by the foetus, so then the combined L–T4 injections into the umbilical vein and intra-amniotically in experienced hands seems to be a reasonable and effective option.

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Keywords

foetal goitre, dyshormonogenesis, L-thyroxine in utero treatment

About this article
Title

Foetal goitrous hypothyroidism — easy to recognise, difficult to treat. Is combined intra-amniotic and intravenous L-thyroxine therapy an option?

Journal

Endokrynologia Polska

Issue

Vol 69, No 4 (2018)

Pages

442-446

Published online

2018-06-29

DOI

10.5603/EP.a2018.0045

Pubmed

29956299

Bibliographic record

Endokrynologia Polska 2018;69(4):442-446.

Keywords

foetal goitre
dyshormonogenesis
L-thyroxine in utero treatment

Authors

Marzena Dębska
Małgorzata Gietka-Czernel
Piotr Kretowicz
Dagmara Filipecka-Tyczka
Łukasz Lewczuk
Joanna Dangel
Romuald Dębski

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