open access

Vol 69, No 6 (2018)
Original Paper
Published online: 2018-09-18
Submitted: 2018-01-15
Accepted: 2018-03-27
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Serum progranulin levels are elevated in infertile women with obesity

Umit Gorkem, Zeynep Ozturk Inal, Hasan Ali Inal, Mehmet Omar Bostanci
DOI: 10.5603/EP.a2018.0044
·
Pubmed: 30229554
·
Endokrynologia Polska 2018;69(6):661-666.

open access

Vol 69, No 6 (2018)
Original Paper
Published online: 2018-09-18
Submitted: 2018-01-15
Accepted: 2018-03-27

Abstract

Introduction: The aim of the present study was to investigate the changes in serum progranulin and sex hormone levels in infertile women with obesity. Material and methods: A total of 171 infertile women who had fertility desire were included in this cross-sectional study. The initial assessment included measurements of weight, height, waist circumference, and hip circumference to calculate body mass index (BMI) and waist/hip ratio. All participants were categorised into two groups in accordance with BMI as a control group ( < 30 kg/m2, n = 135) and a study group (≥ 30 kg/m2, n = 36). After anthropometric measurements, venous blood samples were taken for analyses of oestradiol and follicle stimulating hormone (FSH), luteinising hormone, total testosterone (TT), 17-hydroxyprogesterone, dehydroepiandrosterone sulphate, anti-Müllerian hormone, and progranulin. Results: The present study demonstrated that the overweight women had higher FSH levels (p < 0.01). Elevated TT levels were detected in obese women (p < 0.05). Progranulin concentrations were higher in the study group than in the control group (p < 0.05). Regression analysis demonstrated that there was a relationship between the serum progranulin concentrations and BMI (p < 0.05). Conclusions: Our findings support that the elevated progranulin levels are associated with obesity in infertile women. Therefore, infertile and obese patients may benefit if their serum progranulin levels decrease. Further studies are needed to elucidate this issue.

Abstract

Introduction: The aim of the present study was to investigate the changes in serum progranulin and sex hormone levels in infertile women with obesity. Material and methods: A total of 171 infertile women who had fertility desire were included in this cross-sectional study. The initial assessment included measurements of weight, height, waist circumference, and hip circumference to calculate body mass index (BMI) and waist/hip ratio. All participants were categorised into two groups in accordance with BMI as a control group ( < 30 kg/m2, n = 135) and a study group (≥ 30 kg/m2, n = 36). After anthropometric measurements, venous blood samples were taken for analyses of oestradiol and follicle stimulating hormone (FSH), luteinising hormone, total testosterone (TT), 17-hydroxyprogesterone, dehydroepiandrosterone sulphate, anti-Müllerian hormone, and progranulin. Results: The present study demonstrated that the overweight women had higher FSH levels (p < 0.01). Elevated TT levels were detected in obese women (p < 0.05). Progranulin concentrations were higher in the study group than in the control group (p < 0.05). Regression analysis demonstrated that there was a relationship between the serum progranulin concentrations and BMI (p < 0.05). Conclusions: Our findings support that the elevated progranulin levels are associated with obesity in infertile women. Therefore, infertile and obese patients may benefit if their serum progranulin levels decrease. Further studies are needed to elucidate this issue.

Get Citation

Keywords

progranulin; granulin; obesity; infertility

About this article
Title

Serum progranulin levels are elevated in infertile women with obesity

Journal

Endokrynologia Polska

Issue

Vol 69, No 6 (2018)

Pages

661-666

Published online

2018-09-18

DOI

10.5603/EP.a2018.0044

Pubmed

30229554

Bibliographic record

Endokrynologia Polska 2018;69(6):661-666.

Keywords

progranulin
granulin
obesity
infertility

Authors

Umit Gorkem
Zeynep Ozturk Inal
Hasan Ali Inal
Mehmet Omar Bostanci

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