open access

Vol 69, No 3 (2018)
Original papers
Published online: 2018-04-12
Submitted: 2017-10-25
Accepted: 2017-12-28
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131-I MIBG therapy of malignant pheochromocytoma and paraganglioma tumours — a single-centre study

Agnieszka Kotecka-Blicharz, Kornelia Hasse-Lazar, Daria Handkiewicz-Junak, Tomasz Gawlik, Agnieszka Pawlaczek, Małgorzata Oczko-Wojciechowska, Barbara Michalik, Sylwia Szpak-Ulczok, Jolanta Krajewska, Beata Jurecka-Lubieniecka, Barbara Jarząb
DOI: 10.5603/EP.a2018.0024
·
Pubmed: 29645065
·
Endokrynologia Polska 2018;69(3):246-251.

open access

Vol 69, No 3 (2018)
Original papers
Published online: 2018-04-12
Submitted: 2017-10-25
Accepted: 2017-12-28

Abstract

Introduction: Pheochromocytomas and paragangliomas are rare tumors deriving from chromaffin cells of adrenal medulla or paraganglia. They are usually benign but 10-35% of them present malignant behavior. The aim of the study was to evaluate the efficacy and safety of 131-I MIBG therapy in malignant pheochromocytoma /paraganglioma patients (MPPGL). Material and methods: 18 patients (7 women and 11 men) were included in this study. Between 2002 and 2016 they underwent 131-I MIBG therapy because of MPPGL and their medical data were analyzed retrospectively. Clinical indications for the treatment included progressive disease or massive tissue involvement independently from disease progression. Tumor response for the first time was assessed 3 months after the last treatment according to Response Evaluation Criteria in Solid Tumors criteria and by 131-I MIBG scans. Results: The mean single dose used was 7.25 GBq (196 mCi) and mean cumulative dose 33.08 GBq ( 894 mCi). In 2 (11%) patients complete tumor response was achieved. In 1 (6%) patient partial response was obtained. In 13 (72%) patients stable disease was observed. In 2 (11%) patients progression was diagnosed three months after treatment discontinuation. In the whole studied group the progression free survival time was 85 months and overall 5-year survival was 87%. Conclusions: Radionuclide treatment with use of 131-I MIBG may be effective form of palliative treatment for patients with inoperative neoplasm spread, progressive disease or patients requiring alleviation of symptoms. < p > < /p >

Abstract

Introduction: Pheochromocytomas and paragangliomas are rare tumors deriving from chromaffin cells of adrenal medulla or paraganglia. They are usually benign but 10-35% of them present malignant behavior. The aim of the study was to evaluate the efficacy and safety of 131-I MIBG therapy in malignant pheochromocytoma /paraganglioma patients (MPPGL). Material and methods: 18 patients (7 women and 11 men) were included in this study. Between 2002 and 2016 they underwent 131-I MIBG therapy because of MPPGL and their medical data were analyzed retrospectively. Clinical indications for the treatment included progressive disease or massive tissue involvement independently from disease progression. Tumor response for the first time was assessed 3 months after the last treatment according to Response Evaluation Criteria in Solid Tumors criteria and by 131-I MIBG scans. Results: The mean single dose used was 7.25 GBq (196 mCi) and mean cumulative dose 33.08 GBq ( 894 mCi). In 2 (11%) patients complete tumor response was achieved. In 1 (6%) patient partial response was obtained. In 13 (72%) patients stable disease was observed. In 2 (11%) patients progression was diagnosed three months after treatment discontinuation. In the whole studied group the progression free survival time was 85 months and overall 5-year survival was 87%. Conclusions: Radionuclide treatment with use of 131-I MIBG may be effective form of palliative treatment for patients with inoperative neoplasm spread, progressive disease or patients requiring alleviation of symptoms. < p > < /p >
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Keywords

pheochromocytoma, paraganglioma, MIBG treatment

About this article
Title

131-I MIBG therapy of malignant pheochromocytoma and paraganglioma tumours — a single-centre study

Journal

Endokrynologia Polska

Issue

Vol 69, No 3 (2018)

Pages

246-251

Published online

2018-04-12

DOI

10.5603/EP.a2018.0024

Pubmed

29645065

Bibliographic record

Endokrynologia Polska 2018;69(3):246-251.

Keywords

pheochromocytoma
paraganglioma
MIBG treatment

Authors

Agnieszka Kotecka-Blicharz
Kornelia Hasse-Lazar
Daria Handkiewicz-Junak
Tomasz Gawlik
Agnieszka Pawlaczek
Małgorzata Oczko-Wojciechowska
Barbara Michalik
Sylwia Szpak-Ulczok
Jolanta Krajewska
Beata Jurecka-Lubieniecka
Barbara Jarząb

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