Melatonin receptor 1B gene polymorphism rs10830963 and gestational diabetes mellitus among a Chinese population — a meta-analysis of association studies
Abstract
Introduction: Studies have been conducted to investigate the association between rs10830963 of MTNR1B and the risk of gestational diabetes mellitus (GDM), but with inconclusive results. We aimed to clarify these controversies, especially with regard to the association in the Chinese population.
Material and methods: A systemic literature reference search inclusive to August 12, 2016 yielded 35 articles, from which 11 studies met the inclusion criteria for the final meta-analysis, including 3889 patients with GDM and 6708 controls.
Results: We found statistically significant associations between rs10830963 and GDM using odds ratios (ORs) and 95% confidence intervals (CIs) [GG genotype vs. CC genotype: OR = 1.70, 95% CI: 1.38–2.10; G allele vs C allele: OR = 1.27, 95% CI: 1.20–1.36; GG+CG vs. CC (dominant model): OR = 1.31, 95% CI: 1.20–1.44; GG vs CG+CC (recessive model): OR = 1.41, 95% CI: 1.26–1.58]. In subgroup analyses stratified by ethnicity, we also observed rs10830963 to be associated with significantly increased risk of GDM in all genetic models in the Chinese population.
Conclusions: Our meta-analysis indicated that the rs10830963 polymorphism might serve as a risk factor of GDM in the Chinese population.
Keywords: single nucleotide polymorphismmelatonin receptor 1B genegestational diabetes mellitusmeta-analysis
References
- Ben-Haroush A, Yogev Y, Hod M. Epidemiology of gestational diabetes mellitus and its association with Type 2 diabetes. Diabet Med. 2004; 21(2): 103–113.
- Poomalar GK. Changing trends in management of gestational diabetes mellitus. World J Diabetes. 2015; 6(2): 284–295.
- Yew TW, Khoo CM, Thai AhC, et al. The Prevalence of Gestational Diabetes Mellitus Among Asian Females is Lower Using the New 2013 World Health Organization Diagnostic Criteria. Endocr Pract. 2014; 20(10): 1064–1069.
- Tong GX, Cheng J, Chai J, et al. Association between gestational diabetes mellitus and subsequent risk of cancer: a systematic review of epidemiological studies. Asian Pac J Cancer Prev. 2014; 15(10): 4265–4269.
- Valizadeh M, Alavi N, Mazloomzadeh S, et al. The risk factors and incidence of type 2 diabetes mellitus and metabolic syndrome in women with previous gestational diabetes. Int J Endocrinol Metab. 2015; 13(2): e21696.
- Kim C, Newton KM, Knopp RH. Gestational diabetes and the incidence of type 2 diabetes: a systematic review. Diabetes Care. 2002; 25(10): 1862–1868.
- Wung SF, Lin PC. Shared genomics of type 2 and gestational diabetes mellitus. Annu Rev Nurs Res. 2011; 29: 227–260.
- Rönn T, Wen J, Yang Z, et al. A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals. Diabetologia. 2009; 52(5): 830–833.
- Bouatia-Naji N, Bonnefond A, Cavalcanti-Proença C, et al. A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet. 2009; 41(1): 89–94.
- Zhao Qi, Xiao J, He J, et al. Cross-sectional and longitudinal replication analyses of genome-wide association loci of type 2 diabetes in Han Chinese. PLoS One. 2014; 9(3): e91790.
- Xia Q, Chen ZX, Wang YC, et al. Association between the melatonin receptor 1B gene polymorphism on the risk of type 2 diabetes, impaired glucose regulation: a meta-analysis. PLoS One. 2012; 7(11): e50107.
- Ramracheya RD, Muller DS, Squires PE, et al. Function and expression of melatonin receptors on human pancreatic islets. J Pineal Res. 2008; 44(3): 273–279.
- Mühlbauer E, Gross E, Labucay K, et al. Loss of melatonin signalling and its impact on circadian rhythms in mouse organs regulating blood glucose. Eur J Pharmacol. 2009; 606(1-3): 61–71.
- Melsen WG, Bootsma MCJ, Rovers MM, et al. The effects of clinical and statistical heterogeneity on the predictive values of results from meta-analyses. Clin Microbiol Infect. 2014; 20(2): 123–129.
- Deng ZF, Chen YH, Xiang MH, et al. et al.. Association of genetic variant rs10830963 of melatonin receptor 1B gene in women with gestational diabetes mellitus Clin J Preinat Med. 2011; 14(11): 666–9.
- Kim JY, Cheong HS, Park BL, et al. Melatonin receptor 1 B polymorphisms associated with the risk of gestational diabetes mellitus. BMC Med Genet. 2011; 12: 82.
- Vlassi M, Gazouli M, Paltoglou G, et al. The rs10830963 variant of melatonin receptor MTNR1B is associated with increased risk for gestational diabetes mellitus in a Greek population. Hormones (Athens). 2012; 11(1): 70–76.
- Wang Y, Nie M, Li W, et al. Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a Chinese population. PLoS One. 2011; 6(11): e26953.
- Qi JHG, Wang J. Correlation study between single nucleotide polymorphism of melatonin receptor 1B gene and gestational diabetes mellitus. CHINA MEDICAL HERALD. 2013; 10(3): 4–6.
- Li C, Qiao B, Zhan Y, et al. Association between genetic variations in MTNR1A and MTNR1B genes and gestational diabetes mellitus in Han Chinese women. Gynecol Obstet Invest. 2013; 76(4): 221–227.
- Stuebe AM, Wise A, Nguyen T, et al. Obesity and diabetes genetic variants associated with gestational weight gain. Am J Obstet Gynecol. 2010; 203(3): 283.e1–283.17.
- Wang XD, Bao LS. Association between gene polymorphism of melatonin receptor 1B and gestational diabetes mellitus Chin J Diabetes. 2014;22(398-400.
- Vejrazkova DLP, Vankova M, Bradnova O, et al. MTNR1B genetic variability is associated with gestational diabetes in Czech women. Diabetologia 2014;57. ; 1(SUPPL.1): S448.
- Junior JP, Frigeri HR, Dos Santos-Weiss ICR, et al. The MTNR1B gene polymorphism rs10830963 is associated with gestational diabetes in a Brazilian population. Gene. 2015; 568(1): 114–115.
- Liu Q, Huang Z, Li H, et al. Relationship between melatonin receptor 1B (rs10830963 and rs1387153) with gestational diabetes mellitus: a case-control study and meta-analysis. Arch Gynecol Obstet. 2016; 294(1): 55–61.
- Bellamy L, Casas JP, Hingorani AD, et al. Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet. 2009; 373(9677): 1773–1779.
- Lambrinoudaki I, Vlachou SA, Creatsas G. Genetics in Gestational Diabetes Mellitus: Association with Incidence, Severity, Pregnancy Outcome and Response to Treatment. Current Diabetes Reviews. 2010; 6(6): 393–399.
- Watanabe RM. Inherited destiny? Genetics and gestational diabetes mellitus. Genome Med. 2011; 3(3): 18.
- Zhang C, Bao W, Rong Y, et al. Genetic variants and the risk of gestational diabetes mellitus: a systematic review. Hum Reprod Update. 2013; 19(4): 376–390.
- Kwak SH, Kim SH, Cho YM, et al. A genome-wide association study of gestational diabetes mellitus in Korean women. Diabetes. 2012; 61(2): 531–541.
- McCarthy MI, Abecasis GR, Cardon LR, et al. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet. 2008; 9(5): 356–369.
- Zhang Y, Sun CM, Hu XQ, et al. Relationship between melatonin receptor 1B and insulin receptor substrate 1 polymorphisms with gestational diabetes mellitus: a systematic review and meta-analysis. Sci Rep. 2014; 4: 6113.
- Pandi-Perumal SR, Trakht I, Srinivasan V, et al. Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways. Prog Neurobiol. 2008; 85(3): 335–353.
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