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The “game” of glial fibrillary acidic and S100 proteins in pituitary adenomas: two players or several?
Affiliations- Department of Microscopic Morphology/Histology, Angiogenesis Research Centre, “Victor Babes” University of Medicine and Pharmacy Timişoara, Romania, Romania
- Department of Microscopic Morphology/Histology, Angiogenesis Research Centre, “Victor Babes” University of Medicine and Pharmacy Timişoara, Romania
- Department of Endocrinology, VAsile Goldis University, Arad, Romania, Romania
- Department of Pathology, Nicolae Testemitanu University of Medicine and Pharmacy Chisinau, Moldova, Moldova, Republic Of
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Abstract
Introduction: S100 protein and GFAP expression in pituitary adenomas tumour cells is not well known; few correlations with other prognostic or therapeutic factors have previously been reported in pituitary adenomas. We aim to elucidate their involvement in the pathogenesis of pituitary adenomas and to establish the correlation of their expression with different growth factors and growth factor receptors known to have a prognostic and/or therapeutic role.
Material and methods: Sixty-one cases of pituitary adenomas were immunohistochemically assessed for the expression of GFAP and S100 protein in both tumour cells and FS cells, in close relationship with hormone profile, and correlated with vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) expression, previously studied by our team.
Results: GFAP and S100 protein were expressed both in tumour cells and FS cells. Differences between morphology, distribution, and density of GFAP+ FS cells and S100+ FS cells were observed according to the hormone profile of pituitary adenomas. GFAP and S100 protein expression in tumour cells was significantly related to hormone profile of pituitary adenomas and also with VEGF and EGFR expression.
Conclusions: GFAP and S100 protein expressions in tumour cells from pituitary adenomas are influenced by hormone profile. Our results support the presence of two molecular subtypes of FS cells GFAP+/VEGF+/S100 respectively and another one that is GFAP-/S100+/EGFR+ simultaneously with the classical variant GFAP+/S100+. It is possible that S100+/EGFR+ pituitary adenomas represent a group of pituitary adenomas with an aggressive behaviour and a high ability of invasion and recurrence.
Abstract
Introduction: S100 protein and GFAP expression in pituitary adenomas tumour cells is not well known; few correlations with other prognostic or therapeutic factors have previously been reported in pituitary adenomas. We aim to elucidate their involvement in the pathogenesis of pituitary adenomas and to establish the correlation of their expression with different growth factors and growth factor receptors known to have a prognostic and/or therapeutic role.
Material and methods: Sixty-one cases of pituitary adenomas were immunohistochemically assessed for the expression of GFAP and S100 protein in both tumour cells and FS cells, in close relationship with hormone profile, and correlated with vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) expression, previously studied by our team.
Results: GFAP and S100 protein were expressed both in tumour cells and FS cells. Differences between morphology, distribution, and density of GFAP+ FS cells and S100+ FS cells were observed according to the hormone profile of pituitary adenomas. GFAP and S100 protein expression in tumour cells was significantly related to hormone profile of pituitary adenomas and also with VEGF and EGFR expression.
Conclusions: GFAP and S100 protein expressions in tumour cells from pituitary adenomas are influenced by hormone profile. Our results support the presence of two molecular subtypes of FS cells GFAP+/VEGF+/S100 respectively and another one that is GFAP-/S100+/EGFR+ simultaneously with the classical variant GFAP+/S100+. It is possible that S100+/EGFR+ pituitary adenomas represent a group of pituitary adenomas with an aggressive behaviour and a high ability of invasion and recurrence.
Keywords
S100 protein, GFAP, folliculostellate cells, pituitary adenomas
About this articleTitle
The “game” of glial fibrillary acidic and S100 proteins in pituitary adenomas: two players or several?
Journal
Issue
Article type
Original paper
Pages
380-389
Published online
2017-05-26
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2069
Article views/downloads
1670
DOI
Pubmed
Bibliographic record
Endokrynol Pol 2017;68(4):380-389.
Keywords
S100 protein
GFAP
folliculostellate cells
pituitary adenomas
Authors
Anca Maria Cimpean
Amalia Raluca Ceausu
Ana Corlan
Eugen Melnic
Andreea Adriana Jitariu
Marius Raica
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