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open access

Vol 69, No 2 (2018)
Review paper
Submitted: 2017-10-02
Accepted: 2017-10-09
Published online: 2018-03-29
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Expression of follicle stimulating hormone receptors in intra-tumoral vasculature and in tumoral cells — the involvement in tumour progression and the perspectives of application in cancer diagnosis and therapy

Marek Pawlikowski (Łódź)1
DOI: 10.5603/EP.2018.0022
·
Pubmed: 29952426
·
Endokrynol Pol 2018;69(2):192-198.
Affiliations
  1. Uniwersytet Medyczny w Łodzi, Katedra Endokrynologii, Sterlinga 3, 91-414 Łódź, Poland

open access

Vol 69, No 2 (2018)
Review Article
Submitted: 2017-10-02
Accepted: 2017-10-09
Published online: 2018-03-29

Abstract

In normal conditions follicle stimulating hormone receptors (FSHR) are expressed in zona granulosa cells of the ovary and Sertoli cells of the testis. However, the ectopic expression of FSHR was recently discovered in intra-tumoral blood vessels endothelia and/or in tumoral cells of many extra-gonadal human tumors (particularly in endocrine tumours). The paper reviews the data concerning the appearance of ectopic FSHR in particular human neoplasms. The possible involvement of FSHR in tumor progression and the use of FSHR examination for diagnostic purposes is also reviewed. Finally, the putative role of FSHR as a new target in oncological therapy is also discussed.

Abstract

In normal conditions follicle stimulating hormone receptors (FSHR) are expressed in zona granulosa cells of the ovary and Sertoli cells of the testis. However, the ectopic expression of FSHR was recently discovered in intra-tumoral blood vessels endothelia and/or in tumoral cells of many extra-gonadal human tumors (particularly in endocrine tumours). The paper reviews the data concerning the appearance of ectopic FSHR in particular human neoplasms. The possible involvement of FSHR in tumor progression and the use of FSHR examination for diagnostic purposes is also reviewed. Finally, the putative role of FSHR as a new target in oncological therapy is also discussed.

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Keywords

follicle stimulating hormone receptor, ectopic expression, cancer markers, cancer progression, cancer treatment, follicle stimulating hormone antagonists

About this article
Title

Expression of follicle stimulating hormone receptors in intra-tumoral vasculature and in tumoral cells — the involvement in tumour progression and the perspectives of application in cancer diagnosis and therapy

Journal

Endokrynologia Polska

Issue

Vol 69, No 2 (2018)

Article type

Review paper

Pages

192-198

Published online

2018-03-29

Page views

3004

Article views/downloads

2112

DOI

10.5603/EP.2018.0022

Pubmed

29952426

Bibliographic record

Endokrynol Pol 2018;69(2):192-198.

Keywords

follicle stimulating hormone receptor
ectopic expression
cancer markers
cancer progression
cancer treatment
follicle stimulating hormone antagonists

Authors

Marek Pawlikowski (Łódź)

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