open access

Vol 68, No 1 (2017)
Original Paper
Published online: 2017-03-01
Submitted: 2016-01-16
Accepted: 2016-05-11
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Epidemiology of gastroenteropancreatic neuroendocrine neoplasms in Krakow and Krakow district in 2007-2011.

Małgorzata Trofimiuk-Müldner, Ewelina Lewkowicz, Katarzyna Wysocka, Dorota Pach, Agnieszka Kiełtyka, Agnieszka Stefańska, Anna Sowa-Staszczak, Romana Tomaszewska, Alicja Hubalewska-Dydejczyk
DOI: 10.5603/EP.2017.0006
·
Pubmed: 28255979
·
Endokrynologia Polska 2017;68(1):42-46.

open access

Vol 68, No 1 (2017)
Original Paper
Published online: 2017-03-01
Submitted: 2016-01-16
Accepted: 2016-05-11

Abstract

Introduction: Gastroenteropancreatic neuroendocrine neoplasms (GEPNEN) are rare and heterogeneous tumours with variable biology. The aim of this study was to evaluate the epidemiology of GEPNEN in the population of Krakow and Krakow district in 2007–2011.

Material and methods: The Database of the Chair and Department of Endocrinology, Jagiellonian University Medical College, comprising the data on NEN cases collected from the Endocrinology Department, University Hospital in Krakow and from independent sources: surgery, pathology, and endocrinology departments located in the Krakow area, was searched for cases of GEPNEN patients living in Krakow and Krakow district, diagnosed between 2007 and 2011. Eighty-eight such patients (39 males, 49 females, median age at diagnosis 59 ± 17 years) were identified and characterised.

Results: The mean follow-up time was 2.67 ± 1.6 years. The most frequent primary location of GEPNEN was small intestine (20%), followed by the appendix (18%), stomach (16%), pancreas (16%), rectum (15%), and colon (15%). NENG1 predominated (64%) in the analysed group. Most well-differentiated GEPNEN (63%) were diagnosed at stage I; however, 18% of them were diagnosed at stage IV. Metastases at diagnosis were found in 31% of patients. The GEPNEN incidence rate in 2007–2011 was 2.1/100000 inhabitants/year, without significant increase during the studied period.

Conclusions: GEPNEN incidence and epidemiology in the population of Krakow and Krakow district is similar to the incidence observed in most European countries. Registers are important tools to evaluate GEPNEN epidemiology. (Endokrynol Pol 2017; 68 (1): 42–46)

Abstract

Introduction: Gastroenteropancreatic neuroendocrine neoplasms (GEPNEN) are rare and heterogeneous tumours with variable biology. The aim of this study was to evaluate the epidemiology of GEPNEN in the population of Krakow and Krakow district in 2007–2011.

Material and methods: The Database of the Chair and Department of Endocrinology, Jagiellonian University Medical College, comprising the data on NEN cases collected from the Endocrinology Department, University Hospital in Krakow and from independent sources: surgery, pathology, and endocrinology departments located in the Krakow area, was searched for cases of GEPNEN patients living in Krakow and Krakow district, diagnosed between 2007 and 2011. Eighty-eight such patients (39 males, 49 females, median age at diagnosis 59 ± 17 years) were identified and characterised.

Results: The mean follow-up time was 2.67 ± 1.6 years. The most frequent primary location of GEPNEN was small intestine (20%), followed by the appendix (18%), stomach (16%), pancreas (16%), rectum (15%), and colon (15%). NENG1 predominated (64%) in the analysed group. Most well-differentiated GEPNEN (63%) were diagnosed at stage I; however, 18% of them were diagnosed at stage IV. Metastases at diagnosis were found in 31% of patients. The GEPNEN incidence rate in 2007–2011 was 2.1/100000 inhabitants/year, without significant increase during the studied period.

Conclusions: GEPNEN incidence and epidemiology in the population of Krakow and Krakow district is similar to the incidence observed in most European countries. Registers are important tools to evaluate GEPNEN epidemiology. (Endokrynol Pol 2017; 68 (1): 42–46)

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Keywords

gastroenteropancreatic neuroendocrine neoplasms; incidence; epidemiology

About this article
Title

Epidemiology of gastroenteropancreatic neuroendocrine neoplasms in Krakow and Krakow district in 2007-2011.

Journal

Endokrynologia Polska

Issue

Vol 68, No 1 (2017)

Pages

42-46

Published online

2017-03-01

DOI

10.5603/EP.2017.0006

Pubmed

28255979

Bibliographic record

Endokrynologia Polska 2017;68(1):42-46.

Keywords

gastroenteropancreatic neuroendocrine neoplasms
incidence
epidemiology

Authors

Małgorzata Trofimiuk-Müldner
Ewelina Lewkowicz
Katarzyna Wysocka
Dorota Pach
Agnieszka Kiełtyka
Agnieszka Stefańska
Anna Sowa-Staszczak
Romana Tomaszewska
Alicja Hubalewska-Dydejczyk

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