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Evaluation of adipocytokines in children with chronic kidney disease
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Abstract
of serum adipocytokine concentration in children with chronic kidney disease (CKD) could serve as a marker of cardio-vascular
complication progression and an index of outcome in adulthood and after kidney transplantation.
Material and methods: The aim of the study was to evaluate simultaneously the serum concentrations of six different adipocytokines:
adiponectin, apelin, chemerin, omentin, resistin, and vaspin, in 28 children with CKD stage 5 on haemodialysis and peritoneal dialysis.
Results: The concentration of apelin, omentin, and resistin in children with CKD was significantly higher and the concentration of
vaspin, adiponectin, and chemerin was significantly lower than in the control group. After adjusting to body mass index (BMI), the same
results were obtained. After adjusting to body surface area (BSA), the concentration of vaspin, adiponectin, and chemerin did not differ
between children with CKD and the control group. In analysis of the correlation between serum total adipocytokine levels in children
with CKD we found a negative relationship in pairs: omentin–apelin and omentin–vaspin, and positive in pairs: adiponectin–chemerin
and adiponectin–resistin.
Conclusions: Our results show that changes in serum adipocytokines concentration are associated with the kidney dysfunction in CKD
in children. Longitudinal studies on larger groups of paediatric cohorts would be helpful in investigating whether adipocytokines play
a harmful role in the development of CKD and would enable further understanding of the risk factors for CKD progression.
(Endokrynol Pol 2015; 66 (2): 100–107)
Abstract
of serum adipocytokine concentration in children with chronic kidney disease (CKD) could serve as a marker of cardio-vascular
complication progression and an index of outcome in adulthood and after kidney transplantation.
Material and methods: The aim of the study was to evaluate simultaneously the serum concentrations of six different adipocytokines:
adiponectin, apelin, chemerin, omentin, resistin, and vaspin, in 28 children with CKD stage 5 on haemodialysis and peritoneal dialysis.
Results: The concentration of apelin, omentin, and resistin in children with CKD was significantly higher and the concentration of
vaspin, adiponectin, and chemerin was significantly lower than in the control group. After adjusting to body mass index (BMI), the same
results were obtained. After adjusting to body surface area (BSA), the concentration of vaspin, adiponectin, and chemerin did not differ
between children with CKD and the control group. In analysis of the correlation between serum total adipocytokine levels in children
with CKD we found a negative relationship in pairs: omentin–apelin and omentin–vaspin, and positive in pairs: adiponectin–chemerin
and adiponectin–resistin.
Conclusions: Our results show that changes in serum adipocytokines concentration are associated with the kidney dysfunction in CKD
in children. Longitudinal studies on larger groups of paediatric cohorts would be helpful in investigating whether adipocytokines play
a harmful role in the development of CKD and would enable further understanding of the risk factors for CKD progression.
(Endokrynol Pol 2015; 66 (2): 100–107)
Keywords
adipocytokines; children; chronic kidney disease; adiponectin; apelin; chemerin; omentin; resistin; vaspin
About this articleTitle
Evaluation of adipocytokines in children with chronic kidney disease
Journal
Issue
Article type
Original paper
Pages
100-107
Published online
2015-05-01
Page views
2266
Article views/downloads
2559
DOI
10.5603/EP.2015.0015
Pubmed
Bibliographic record
Endokrynol Pol 2015;66(2):100-107.
Keywords
adipocytokines
children
chronic kidney disease
adiponectin
apelin
chemerin
omentin
resistin
vaspin
Authors
Maria Szczepańska
Edyta Machura
Piotr Adamczyk
Elżbieta Świętochowska
Elżbieta Trembecka-Dubel
Katarzyna Lipiec
Agnieszka Jędzura
Katarzyna Ziora
