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Fasting and postprandial acyl and desacyl ghrelin levels in obese and non-obese subjects
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Abstract
Introduction: The potentially differential roles of both forms of ghrelin in obesity are undefined, and little is known about desacyl ghrelin’s (DAG) regulation by meals. We aimed to assess changes in acyl ghrelin (AG) and DAG in response to mixed-meal consumption in obese and non-obese subjects.
Material and methods: Venous blood for plasma glucose, AG and DAG assays were collected in both groups after an overnight fast and two hours after the consumption of a standard 300 kcal-mixed meal (Nutridrink, Nutricia).
Results: Mean fasting values of both AG and DAG were significantly lower in the obese individuals. On the other hand, among non-obese controls, the mean postprandial DAG levels did not change and AG levels decreased, whereas in obese individuals the mean DAG levels after a mixed-meal diminished and AG levels were unchanged.
Conclusions: It is necessary to distinguish between the desacylated and acylated forms of ghrelin, as we have shown differential postprandial AG and DAG responses in obese and non-obese individuals. Whether targeting changed proportions between AG and DAG could be a successful strategy in obesity treatment remains a question for future studies. (Endokrynol Pol 2014; 65 (5): 377–381)
Abstract
Introduction: The potentially differential roles of both forms of ghrelin in obesity are undefined, and little is known about desacyl ghrelin’s (DAG) regulation by meals. We aimed to assess changes in acyl ghrelin (AG) and DAG in response to mixed-meal consumption in obese and non-obese subjects.
Material and methods: Venous blood for plasma glucose, AG and DAG assays were collected in both groups after an overnight fast and two hours after the consumption of a standard 300 kcal-mixed meal (Nutridrink, Nutricia).
Results: Mean fasting values of both AG and DAG were significantly lower in the obese individuals. On the other hand, among non-obese controls, the mean postprandial DAG levels did not change and AG levels decreased, whereas in obese individuals the mean DAG levels after a mixed-meal diminished and AG levels were unchanged.
Conclusions: It is necessary to distinguish between the desacylated and acylated forms of ghrelin, as we have shown differential postprandial AG and DAG responses in obese and non-obese individuals. Whether targeting changed proportions between AG and DAG could be a successful strategy in obesity treatment remains a question for future studies. (Endokrynol Pol 2014; 65 (5): 377–381)
Keywords
desacyl ghrelin; acyl ghrelin; obesity; meals
About this articleTitle
Fasting and postprandial acyl and desacyl ghrelin levels in obese and non-obese subjects
Journal
Issue
Article type
Original paper
Pages
377-381
Published online
2014-10-09
Page views
2386
Article views/downloads
2703
DOI
10.5603/EP.2014.0052
Bibliographic record
Endokrynol Pol 2014;65(5):377-381.
Keywords
desacyl ghrelin
acyl ghrelin
obesity
meals
Authors
Jolanta Anna Dardzińska
Sylwia Małgorzewicz
Łukasz Kaska
Monika Proczko
Tomasz Stefaniak
Marta Stankiewicz
Zbigniew Śledziński
