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Fetuin-A levels in lean and obese women with polycystic ovary syndrome
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Abstract
Introduction: The aim of this study was to estimate serum fetuin-A levels in lean and obese women with polycystic ovary syndrome (PCOS) and to find possible relationships between fetuin-A, metabolic factors and androgens in these patients.
Material and methods: In 25 lean (18–38 years, BMI 17.5–25.0 kg/m2) and 15 obese women (20–41 years, BMI 28.1–53.2 kg/m2) with PCOS, anthropometric indices and body composition were measured. Fasting serum fetuin-A, adiponectin, leptin, glucose, lipids, hsCRP, insulin, androgens and SHGB levels were estimated.
Results: There was no significant difference in serum fetuin-A levels between lean and obese patients: 0.54 ± 0.13 g/L and 0.60 ± 0.14 g/L, respectively. We noted a correlation between BMI and leptin levels (r = 0.88; p < 0.0001) and a nearly significant negative correlation between BMI and adiponectin levels (r = –0.53; p = 0.11) in all subjects. In lean patients, we found a correlation between fetuin-A levels and ALT activity (r = 0.44; p < 0.05). In all participants, fetuin-A correlated directly with DHEA-S levels (r = 0.44; p < 0.03).
Conclusions: Serum fetuin-A levels were similar in lean and obese women with PCOS. We found an association between fetuin-A levels and ALT activity in lean patients and between fetuin-A levels and DHEA-S in all women. The role of fetuin-A in the mechanisms of insulin resistance, and its potential impact on androgenic hormones production in women with PCOS, need to be tested in further studies. (Endokrynol Pol 2014; 65 (5): 371–376)
Abstract
Introduction: The aim of this study was to estimate serum fetuin-A levels in lean and obese women with polycystic ovary syndrome (PCOS) and to find possible relationships between fetuin-A, metabolic factors and androgens in these patients.
Material and methods: In 25 lean (18–38 years, BMI 17.5–25.0 kg/m2) and 15 obese women (20–41 years, BMI 28.1–53.2 kg/m2) with PCOS, anthropometric indices and body composition were measured. Fasting serum fetuin-A, adiponectin, leptin, glucose, lipids, hsCRP, insulin, androgens and SHGB levels were estimated.
Results: There was no significant difference in serum fetuin-A levels between lean and obese patients: 0.54 ± 0.13 g/L and 0.60 ± 0.14 g/L, respectively. We noted a correlation between BMI and leptin levels (r = 0.88; p < 0.0001) and a nearly significant negative correlation between BMI and adiponectin levels (r = –0.53; p = 0.11) in all subjects. In lean patients, we found a correlation between fetuin-A levels and ALT activity (r = 0.44; p < 0.05). In all participants, fetuin-A correlated directly with DHEA-S levels (r = 0.44; p < 0.03).
Conclusions: Serum fetuin-A levels were similar in lean and obese women with PCOS. We found an association between fetuin-A levels and ALT activity in lean patients and between fetuin-A levels and DHEA-S in all women. The role of fetuin-A in the mechanisms of insulin resistance, and its potential impact on androgenic hormones production in women with PCOS, need to be tested in further studies. (Endokrynol Pol 2014; 65 (5): 371–376)
Keywords
polycystic ovary syndrome; fetuin-A; obesity; insulin resistance
About this articleTitle
Fetuin-A levels in lean and obese women with polycystic ovary syndrome
Journal
Issue
Article type
Original paper
Pages
371-376
Published online
2014-10-09
Page views
2149
Article views/downloads
2538
DOI
10.5603/EP.2014.0051
Bibliographic record
Endokrynol Pol 2014;65(5):371-376.
Keywords
polycystic ovary syndrome
fetuin-A
obesity
insulin resistance
Authors
Jarosław Kozakowski
Wojciech Jeske
Wojciech Zgliczyński
