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Human papillomavirus and Epstein-Barr virus infection in benign thyroid lesions
, 2, 3, 3, 3
Affiliations- School of Medicine, Shanghai University, Shanghai, China
- Postgraduate Training Base at Shanghai Gongli Hospital, Ningxia Medical University, Shanghai, China
- Department of Otolaryngology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, China
open access
Abstract
Introduction: The objective was to investigate the correlation between Epstein-Barr virus (EBV) and human papillomavirus (HPV) infection in the development of benign thyroid lesions.
Material and methods: 29 cases of Hashimoto’s thyroiditis (HT), 133 cases of thyroid adenoma, and 34 cases of HT with thyroid adenoma paraffin embedded tissue samples were used for EBV and HPV quantitative detection.
Results: None of the tissue samples carried HPV DNA. In HT tissue samples, the positive rate of EBV was 55.2% (16/29). In thyroid adenoma tissue samples, the positive rate was 37.6% (50/133). In HT combined with thyroid adenoma tissue samples, the positive rate of EBV was 67.6% (23/34). There was no correlation between EBV infection and clinical features such as age and gender.
Conclusion: The occurrence and development of benign thyroid lesions are closely related to EBV infection. HT combined with thyroid adenoma may be more susceptible to EBV infection than simple HT and thyroid adenoma, which provides a new idea for the diagnosis and treatment of benign thyroid lesions.
Abstract
Introduction: The objective was to investigate the correlation between Epstein-Barr virus (EBV) and human papillomavirus (HPV) infection in the development of benign thyroid lesions.
Material and methods: 29 cases of Hashimoto’s thyroiditis (HT), 133 cases of thyroid adenoma, and 34 cases of HT with thyroid adenoma paraffin embedded tissue samples were used for EBV and HPV quantitative detection.
Results: None of the tissue samples carried HPV DNA. In HT tissue samples, the positive rate of EBV was 55.2% (16/29). In thyroid adenoma tissue samples, the positive rate was 37.6% (50/133). In HT combined with thyroid adenoma tissue samples, the positive rate of EBV was 67.6% (23/34). There was no correlation between EBV infection and clinical features such as age and gender.
Conclusion: The occurrence and development of benign thyroid lesions are closely related to EBV infection. HT combined with thyroid adenoma may be more susceptible to EBV infection than simple HT and thyroid adenoma, which provides a new idea for the diagnosis and treatment of benign thyroid lesions.
Keywords
Hashimoto’s thyroiditis; thyroid adenoma; EB virus; human papilloma virus
About this articleTitle
Human papillomavirus and Epstein-Barr virus infection in benign thyroid lesions
Journal
Issue
Article type
Original paper
Pages
179-182
Published online
2024-04-22
Page views
117
Article views/downloads
56
DOI
Pubmed
Bibliographic record
Endokrynol Pol 2024;75(2):179-182.
Keywords
Hashimoto’s thyroiditis
thyroid adenoma
EB virus
human papilloma virus
Authors
Yingying Lu
Runyu Zhao
Yi Zhang
Shuixian Huang
Xiaoping Chen
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