open access
Vol 74, No 5 (2023)
Review paper
Submitted: 2023-04-30
Accepted: 2023-07-14
Published online: 2023-10-09
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Adipose tissue as a cause of endocrine dysfunction
12
Affiliations- Department of Human Epigenetics, Mossakowski Medical Research Centre PAS, Warsaw, Poland
- Department of General Medicine and Geriatric Cardiology, Medical Centre of Postgraduate Education Warsaw, Poland
open access
Vol 74, No 5 (2023)
Review Article
Submitted: 2023-04-30
Accepted: 2023-07-14
Published online: 2023-10-09
Abstract
Adipose tissue is a large hormonally active organ that secretes several substances (adipokines), and an important site for the synthesis and metabolism of steroid hormones. With energy balance, the secretory and metabolic activity of adipose tissue determines the normal function of many organs, including the endocrine glands. However, in the course of overweight and obesity, adverse changes occur in the structure and function of adipocytes. Obesity-related adipose tissue dysfunction translates into a change in the profile of secreted adipokines, and it impairs steroidogenesis. These phenomena contribute to the development of obesity-related complications, which also affect the major tropic axes regulating the endocrine glands. However, there is increasing evidence that weight reduction is an effective treatment for obesity-related adipose tissue dysfunction, thereby restoring endocrine function.
This narrative review presents the impact of adipose tissue on endocrine gland activity both in the physiological state and in obesity-related dysfunction. It also discusses how functional (related to excess adiposity) changes in the endocrine system can be restored with effective treatment of obesity.
Abstract
Adipose tissue is a large hormonally active organ that secretes several substances (adipokines), and an important site for the synthesis and metabolism of steroid hormones. With energy balance, the secretory and metabolic activity of adipose tissue determines the normal function of many organs, including the endocrine glands. However, in the course of overweight and obesity, adverse changes occur in the structure and function of adipocytes. Obesity-related adipose tissue dysfunction translates into a change in the profile of secreted adipokines, and it impairs steroidogenesis. These phenomena contribute to the development of obesity-related complications, which also affect the major tropic axes regulating the endocrine glands. However, there is increasing evidence that weight reduction is an effective treatment for obesity-related adipose tissue dysfunction, thereby restoring endocrine function.
This narrative review presents the impact of adipose tissue on endocrine gland activity both in the physiological state and in obesity-related dysfunction. It also discusses how functional (related to excess adiposity) changes in the endocrine system can be restored with effective treatment of obesity.
Get Citation
Keywords
adipose tissue; adipokines; hormonal homeostasis; obesity; adipose tissue dysfunction; lifestyle interventions; glucagon-like peptide 1 receptor agonists (GLP-1RAs); bariatric surgery
About this articleTitle
Adipose tissue as a cause of endocrine dysfunction
Journal
Issue
Article type
Review paper
Pages
468-479
Published online
2023-10-09
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981
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683
DOI
Pubmed
Bibliographic record
Endokrynol Pol 2023;74(5):468-479.
Keywords
adipose tissue
adipokines
hormonal homeostasis
obesity
adipose tissue dysfunction
lifestyle interventions
glucagon-like peptide 1 receptor agonists (GLP-1RAs)
bariatric surgery
Authors
Alina Ewa Kuryłowicz
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