Amino acids profile in girls with Turner syndrome during growth hormone therapy
, 1, 2, 2, 1
Abstract
Introduction: The influence of growth hormone (GH) treatment on amino acids (AAs) profile in patients with Turner syndrome (TS) was investigated.
Material and methods: The study group included girls with TS: treated with GH (GH+) and girls with no GH treatment (GH−). The control group consisted of healthy girls. Free plasma AAs were measured by the LC/MS/MS.
Results: The plasma concentrations of glutamine, threonine were significantly higher in group GH+ than in group GH− (p < 0.05). In group GH− the values of glutamine, alanine, isoleucine, glutamic acid were significantly different than in the control (p < 0.05–p < 0.008).
Conclusion: AAs profile in girls with TS might be characteristic for the disease but also depends on GH treatment.
Keywords: amino acidsgrowth hormoneTurner syndrome
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