open access

Vol 72, No 1 (2021)
Brief communication
Published online: 2021-01-19
Submitted: 2020-12-10
Accepted: 2020-12-20
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Amino acids profile in girls with Turner syndrome during growth hormone therapy

Jolanta Bugajska, Joanna Berska, Małgorzata Wójcik, Jerzy B. Starzyk, Krystyna Sztefko
DOI: 10.5603/EP.a2020.0091
·
Pubmed: 33619714
·
Endokrynologia Polska 2021;72(1):51-52.

open access

Vol 72, No 1 (2021)
Short communication
Published online: 2021-01-19
Submitted: 2020-12-10
Accepted: 2020-12-20

Abstract

Introduction: The influence of growth hormone (GH) treatment on amino acids (AAs) profile in patients with Turner syndrome (TS) was investigated.

Material and methods: The study group included girls with TS: treated with GH (GH+) and girls with no GH treatment (GH−). The control group consisted of healthy girls. Free plasma AAs were measured by the LC/MS/MS.

Results: The plasma concentrations of glutamine, threonine were significantly higher in group GH+ than in group GH− (p < 0.05). In group GH− the values of glutamine, alanine, isoleucine, glutamic acid were significantly different than in the control (p < 0.05–p < 0.008).

Conclusion: AAs profile in girls with TS might be characteristic for the disease but also depends on GH treatment.

Abstract

Introduction: The influence of growth hormone (GH) treatment on amino acids (AAs) profile in patients with Turner syndrome (TS) was investigated.

Material and methods: The study group included girls with TS: treated with GH (GH+) and girls with no GH treatment (GH−). The control group consisted of healthy girls. Free plasma AAs were measured by the LC/MS/MS.

Results: The plasma concentrations of glutamine, threonine were significantly higher in group GH+ than in group GH− (p < 0.05). In group GH− the values of glutamine, alanine, isoleucine, glutamic acid were significantly different than in the control (p < 0.05–p < 0.008).

Conclusion: AAs profile in girls with TS might be characteristic for the disease but also depends on GH treatment.

Get Citation

Keywords

amino acids, growth hormone, Turner syndrome

About this article
Title

Amino acids profile in girls with Turner syndrome during growth hormone therapy

Journal

Endokrynologia Polska

Issue

Vol 72, No 1 (2021)

Article type

Brief communication

Pages

51-52

Published online

2021-01-19

DOI

10.5603/EP.a2020.0091

Pubmed

33619714

Bibliographic record

Endokrynologia Polska 2021;72(1):51-52.

Keywords

amino acids
growth hormone
Turner syndrome

Authors

Jolanta Bugajska
Joanna Berska
Małgorzata Wójcik
Jerzy B. Starzyk
Krystyna Sztefko

References (9)
  1. Ahn JM, Suh JH, Kwon AhR, et al. Final Adult Height after Growth Hormone Treatment in Patients with Turner Syndrome. Horm Res Paediatr. 2019; 91(6): 373–379.
  2. Fernholm R, Thoren M, Hoybye C, et al. Amino acid profiles in adults with growth hormone (GH) deficiency before and during GH replacement therapy. Growth Horm IGF Res. 2009; 19(3): 206–211.
  3. Lundeberg S, Belfrage M, Wernerman J, et al. Growth hormone improves muscle protein metabolism and whole body nitrogen economy in man during a hyponitrogenous diet. Metabolism. 1991; 40(3): 315–322.
  4. Höybye C, Wahlström E, Tollet-Egnell P, et al. Metabolomics: a tool for the diagnosis of GH deficiency and for monitoring GH replacement? Endocr Connect. 2014; 3(4): 200–206.
  5. Salomon F, Cuneo R, Sönksen PH. Growth hormone and protein metabolism. Horm Res. 1991; 36 Suppl 1: 41–43.
  6. Bugajska J, Berska J, Wójcik M, et al. Metabolic Fingerprint of Turner Syndrome. J Clin Med. 2020; 9(3).
  7. Xu R, Zhu H, Zhang C, et al. Metabolomic analysis reveals metabolic characteristics of children with short stature caused by growth hormone deficiency. Clin Sci (Lond). 2019; 133(6): 777–788.
  8. Chen Y, Tsai YH, Tseng BJ, et al. Influence of Growth Hormone and Glutamine on Intestinal Stem Cells: A Narrative Review. Nutrients. 2019; 11(8).
  9. Tam CS, Johnson WD, Rood J, et al. Increased Human Growth Hormone After Oral Consumption of an Amino Acid Supplement: Results of a Randomized, Placebo-Controlled, Double-Blind, Crossover Study in Healthy Subjects. Am J Ther. 2020; 27(4): e333–e337.

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