Amino acids profile in girls with Turner syndrome during growth hormone therapy
Abstract
Introduction: The influence of growth hormone (GH) treatment on amino acids (AAs) profile in patients with Turner syndrome (TS) was investigated.
Material and methods: The study group included girls with TS: treated with GH (GH+) and girls with no GH treatment (GH−). The control group consisted of healthy girls. Free plasma AAs were measured by the LC/MS/MS.
Results: The plasma concentrations of glutamine, threonine were significantly higher in group GH+ than in group GH− (p < 0.05). In group GH− the values of glutamine, alanine, isoleucine, glutamic acid were significantly different than in the control (p < 0.05–p < 0.008).
Conclusion: AAs profile in girls with TS might be characteristic for the disease but also depends on GH treatment.
Keywords: amino acidsgrowth hormoneTurner syndrome
References
- Ahn JM, Suh JH, Kwon AhR, et al. Final Adult Height after Growth Hormone Treatment in Patients with Turner Syndrome. Horm Res Paediatr. 2019; 91(6): 373–379.
- Fernholm R, Thoren M, Hoybye C, et al. Amino acid profiles in adults with growth hormone (GH) deficiency before and during GH replacement therapy. Growth Horm IGF Res. 2009; 19(3): 206–211.
- Lundeberg S, Belfrage M, Wernerman J, et al. Growth hormone improves muscle protein metabolism and whole body nitrogen economy in man during a hyponitrogenous diet. Metabolism. 1991; 40(3): 315–322.
- Höybye C, Wahlström E, Tollet-Egnell P, et al. Metabolomics: a tool for the diagnosis of GH deficiency and for monitoring GH replacement? Endocr Connect. 2014; 3(4): 200–206.
- Salomon F, Cuneo R, Sönksen PH. Growth hormone and protein metabolism. Horm Res. 1991; 36 Suppl 1: 41–43.
- Bugajska J, Berska J, Wójcik M, et al. Metabolic Fingerprint of Turner Syndrome. J Clin Med. 2020; 9(3).
- Xu R, Zhu H, Zhang C, et al. Metabolomic analysis reveals metabolic characteristics of children with short stature caused by growth hormone deficiency. Clin Sci (Lond). 2019; 133(6): 777–788.
- Chen Y, Tsai YH, Tseng BJ, et al. Influence of Growth Hormone and Glutamine on Intestinal Stem Cells: A Narrative Review. Nutrients. 2019; 11(8).
- Tam CS, Johnson WD, Rood J, et al. Increased Human Growth Hormone After Oral Consumption of an Amino Acid Supplement: Results of a Randomized, Placebo-Controlled, Double-Blind, Crossover Study in Healthy Subjects. Am J Ther. 2020; 27(4): e333–e337.
