Associations of oxytocin with metabolic parameters in obese women of childbearing age
Abstract
Introduction: The aim of this study was to compare plasma oxytocin levels in obese women of childbearing age with non-obese women of childbearing age, and to investigate the relationship between plasma oxytocin levels and metabolic parameters (including blood glucose, insulin resistance, blood lipid, and blood pressure).
Material and methods: A total of 151 obese women of childbearing age and 160 non-obese women of childbearing age were enrolled in this study. Plasma oxytocin levels were measured by electrochemiluminescence immunoassays. Height, body weight, body mass index (BMI), fasting blood glucose (FBG), fasting insulin (FI), homeostasis model assessment for insulin resistance (HOMA-IR), total triglycerides (TG), total cholesterol (TC), low-density lipoprotein-C (LDL-C), high-density lipoprotein-C (HDL-C), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were measured in all subjects. Quantile regression analysis was used to analyse the associations of plasma
oxytocin levels with FBG, FI, HOMA-IR, TG, TC, LDL-C, HDL-C, SBP, and DBP.
Results: In obese women of childbearing age, plasma oxytocin levels were lower compared with non-obese controls. After adjusting for age, quantile regression analysis showed that the plasma oxytocin levels were inversely associated with HOMA-IR at the quantile level between 0.27 and 0.79 (i.e. the HOMA-IR level of 2.11 and 3.07, respectively), the plasma oxytocin levels were inversely associated with TC after the quantile level of 0.21 (i.e. the TC level of 3.78 ), and the plasma oxytocin levels were inversely associated with LDL-C at all quantile levels of LDL-C. In addition, the plasma oxytocin levels showed a positive association with HDL-C at all quantile levels of HDL-C.
No significant associations were found between the plasma oxytocin levels and FBG, FI, TG, SBP, and DBP.
Conclusions: Oxytocin deficiency was common in obese women of childbearing age. Oxytocin showed negative correlation with HOMA-IR, TC, and LDL-C, while it showed positive association with HDL-C. Our findings suggest that oxytocin played an important role in inhibiting metabolic disorders associated with obesity in women of childbearing age.
Keywords: oxytocinobesitywomenchildbearingbody mass indexinsulin resistancelipidsquantile regression analysis
References
- Barich F, Zahrou FE, Laamiri FZ, et al. Association of Obesity and Socioeconomic Status among Women of Childbearing Age Living in Urban Area of Morocco. J Nutr Metab. 2018; 2018: 6043042.
- Broughton DE, Moley KH. Obesity and female infertility: potential mediators of obesity's impact. Fertil Steril. 2017; 107(4): 840–847.
- Declercq E, MacDorman M, Cabral H, et al. Prepregnancy Body Mass Index and Infant Mortality in 38 U.S. States, 2012-2013. Obstet Gynecol. 2016; 127(2): 279–287.
- Stang J, Huffman LG. Position of the Academy of Nutrition and Dietetics: Obesity, Reproduction, and Pregnancy Outcomes. J Acad Nutr Diet. 2016; 116(4): 677–691.
- Walzem RL, Chen Se. Obesity-induced dysfunctions in female reproduction: lessons from birds and mammals. Adv Nutr. 2014; 5(2): 199–206.
- Pucci G, Alcidi R, Tap L, et al. Sex- and gender-related prevalence, cardiovascular risk and therapeutic approach in metabolic syndrome: A review of the literature. Pharmacol Res. 2017; 120: 34–42.
- Appelman Y, van Rijn BB, Ten Haaf ME, et al. Sex differences in cardiovascular risk factors and disease prevention. Atherosclerosis. 2015; 241(1): 211–218.
- National Center for Health Statistics (US). Health, United States, 2015: with Special Feature on Racial and Ethnic Health Disparities. National Center for Health Statistics (US), Hyattsville, MD 2016: Report No: 2016-1232.–1232.
- O'Connor SG, Habre R, Bastain TM, et al. Within-subject effects of environmental and social stressors on pre- and post-partum obesity-related biobehavioral responses in low-income Hispanic women: protocol of an intensive longitudinal study. BMC Public Health. 2019; 19(1): 253.
- Siega-Riz AM. Prepregnancy obesity: determinants, consequences, and solutions. Adv Nutr. 2012; 3(1): 105–107.
- Lawson EA. The effects of oxytocin on eating behaviour and metabolism in humans. Nat Rev Endocrinol. 2017; 13(12): 700–709.
- Blevins JE, Graham JL, Morton GJ, et al. Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys. Am J Physiol Regul Integr Comp Physiol. 2015; 308(5): R431–R438.
- Spetter MS, Hallschmid M. Current findings on the role of oxytocin in the regulation of food intake. Physiol Behav. 2017; 176: 31–39.
- Maestrini S, Mele C, Mai S, et al. Plasma Oxytocin Concentration in Pre- and Postmenopausal Women: Its Relationship with Obesity, Body Composition and Metabolic Variables. Obes Facts. 2018; 11(5): 429–439.
- Jameson H, Bateman R, Byrne P, et al. Oxytocin neuron activation prevents hypertension that occurs with chronic intermittent hypoxia/hypercapnia in rats. Am J Physiol Heart Circ Physiol. 2016; 310(11): H1549–H1557.
- Tofiq KO, Bulatova N, Kasabri V, et al. Increased lipocalin-2 vs reduced oxytocin in relation with adiposity, atherogenicity and hematological indices in metabolic syndrome patients with and without prediabetes. Bratisl Lek Listy. 2018; 119(12): 762–769.
- Qian W, Zhu T, Tang B, et al. Decreased circulating levels of oxytocin in obesity and newly diagnosed type 2 diabetic patients. J Clin Endocrinol Metab. 2014; 99(12): 4683–4689.
- Grigoryan OR, Mikheev RK, Andreeva EN, et al. Comparative analysis of ovarian reserve in women with obesity in reproductive period. Ter Arkh. 2018; 90(10): 30–34.
- Michalakis K, Mintziori G, Kaprara A, et al. The complex interaction between obesity, metabolic syndrome and reproductive axis: a narrative review. Metabolism. 2013; 62(4): 457–478.
- De Melo VU, Saldanha RRM, Dos Santos CR, et al. Ovarian Hormone Deprivation Reduces Oxytocin Expression in Paraventricular Nucleus Preautonomic Neurons and Correlates with Baroreflex Impairment in Rats. Front Physiol. 2016; 7: 461.
- Zhou B. Coorperative Meta-Analysis Group Of China Obesity Task Force. [Predictive values of body mass index and waist circumference to risk factors of related diseases in Chinese adult population]. Zhonghua Liu Xing Bing Xue Za Zhi. 2002; 23(1): 5–10.
- World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013; 310(20): 2191–2194.
- Wei Y, Pere A, Koenker R, et al. Quantile regression methods for reference growth charts. Stat Med. 2006; 25(8): 1369–1382.
- Beranger GE, Pisani DF, Castel J, et al. Oxytocin reverses ovariectomy-induced osteopenia and body fat gain. Endocrinology. 2014; 155(4): 1340–1352.
- Blevins JE, Ho JM. Role of oxytocin signaling in the regulation of body weight. Rev Endocr Metab Disord. 2013; 14(4): 311–329.
- Morton GJ, Thatcher BS, Reidelberger RD, et al. Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats. Am J Physiol Endocrinol Metab. 2012; 302(1): E134–E144.
- Deblon N, Veyrat-Durebex C, Bourgoin L, et al. Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats. PLoS One. 2011; 6(9): e25565.
- Roberts ZS, Wolden-Hanson T, Matsen ME, et al. Chronic hindbrain administration of oxytocin is sufficient to elicit weight loss in diet-induced obese rats. Am J Physiol Regul Integr Comp Physiol. 2017; 313(4): R357–R371.
- Olszewski PK, Klockars A, Levine AS. Oxytocin and potential benefits for obesity treatment. Curr Opin Endocrinol Diabetes Obes. 2017; 24(5): 320–325.
- Blevins JE, Baskin DG. Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans. Physiol Behav. 2015; 152(Pt B): 438–449.
- Jahromi BN, Dabbaghmanesh MH, Bakhshaie P, et al. Assessment of oxytocin level, glucose metabolism components and cutoff values for oxytocin and anti-mullerian hormone in infertile PCOS women. Taiwan J Obstet Gynecol. 2018; 57(4): 555–559.
- Al-Rawashdeh A, Kasabri V, Bulatova N, et al. The correlation between plasma levels of oxytocin and betatrophin in non-diabetic and diabetic metabolic syndrome patients: A cross sectional study from Jordan. Diabetes Metab Syndr. 2017; 11(1): 59–67.
- Szulc P, Amri EzZ, Varennes A, et al. High serum oxytocin is associated with metabolic syndrome in older men - The MINOS study. Diabetes Res Clin Pract. 2016; 122: 17–27.
- Binay Ç, Paketçi C, Güzel S, et al. Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children. J Clin Res Pediatr Endocrinol. 2017; 9(2): 124–131.
- Lucio-Oliveira F, Franci CR. Effect of the interaction between food state and the action of estrogen on oxytocinergic system activity. J Endocrinol. 2012; 212(2): 129–138.
- Sloan DK, Spencer DS, Curtis KS. Estrogen effects on oxytocinergic pathways that regulate food intake. Horm Behav. 2018; 105: 128–137.
- Stock S, Granström L, Backman L, et al. Elevated plasma levels of oxytocin in obese subjects before and after gastric banding. Int J Obes. 1989; 13(2): 213–222.
