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Vol 69, No 5 (2018)
Guidelines / Expert consensus
Published online: 2018-08-17

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National Program of Severe Growth Hormone Deficiency Treatment in Adults and Adolescents after Completion of Growth Promoting Therapy

Andrzej Lewiński12, Joanna Smyczyńska2, Renata Stawerska2, Maciej Hilczer3, Magdalena Stasiak2, Tomasz Bednarczuk4, Marek Bolanowski5, Roman Junik6, Marek Ruchała7, Anhelli Syrenicz8, Mieczysław Walczak9, Wojciech Zgliczyński10, Małgorzata Karbownik-Lewińska211
Pubmed: 30117531
Endokrynol Pol 2018;69(5):468-524.


Growth hormone (GH) has been used in the treatment of short stature in children with GH deficiency (GHD) for 60 years, and for about 30 years also in the treatment of adults with GHD, in whom such treatment is carried out due to metabolic indications. In Poland, GH treatment is reimbursed only in children with GHD, while so far it has not been refunded in adults with GHD. There are two groups of adults (or adolescents after growth completion) with GHD, who require GH therapy: patients with GHD that occurred in childhood (childhood-onset GHD — CO-GHD) and patients with GHD acquired in adulthood (adulthood-onset GHD — AO-GHD). This review presents a brief outline of the history of GH treatment in humans, the latest data on the causes and symptoms of GHD in adults, and the complications of untreated GHD. Current recommendations regarding diagnosis, treatment and monitoring of GH therapy in adults are also discussed. Moreover, the review paper presents the objectives, assumptions, and plans of implementation of the “National Treatment Program for Severe Growth Hormone Deficiency in Adults and Adolescents after Completion of the Growth Promoting Therapy”, as well as the expected health and economic effects of introduction of GH treatment in adults with GHD in Poland.

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