open access

Vol 65, No 5 (2014)
Original papers
Published online: 2014-10-09
Submitted: 2014-10-10
Accepted: 2014-10-10
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Fasting and postprandial acyl and desacyl ghrelin levels in obese and non-obese subjects

Jolanta Anna Dardzińska, Sylwia Małgorzewicz, Łukasz Kaska, Monika Proczko, Tomasz Stefaniak, Marta Stankiewicz, Zbigniew Śledziński
DOI: 10.5603/EP.2014.0052
·
Endokrynologia Polska 2014;65(5):377-381.

open access

Vol 65, No 5 (2014)
Original papers
Published online: 2014-10-09
Submitted: 2014-10-10
Accepted: 2014-10-10

Abstract

Introduction: The potentially differential roles of both forms of ghrelin in obesity are undefined, and little is known about desacyl ghrelin’s (DAG) regulation by meals. We aimed to assess changes in acyl ghrelin (AG) and DAG in response to mixed-meal consumption in obese and non-obese subjects.

Material and methods: Venous blood for plasma glucose, AG and DAG assays were collected in both groups after an overnight fast and two hours after the consumption of a standard 300 kcal-mixed meal (Nutridrink, Nutricia).

Results: Mean fasting values of both AG and DAG were significantly lower in the obese individuals. On the other hand, among non-obese controls, the mean postprandial DAG levels did not change and AG levels decreased, whereas in obese individuals the mean DAG levels after a mixed-meal diminished and AG levels were unchanged.

Conclusions: It is necessary to distinguish between the desacylated and acylated forms of ghrelin, as we have shown differential postprandial AG and DAG responses in obese and non-obese individuals. Whether targeting changed proportions between AG and DAG could be a successful strategy in obesity treatment remains a question for future studies. (Endokrynol Pol 2014; 65 (5): 377–381)

Abstract

Introduction: The potentially differential roles of both forms of ghrelin in obesity are undefined, and little is known about desacyl ghrelin’s (DAG) regulation by meals. We aimed to assess changes in acyl ghrelin (AG) and DAG in response to mixed-meal consumption in obese and non-obese subjects.

Material and methods: Venous blood for plasma glucose, AG and DAG assays were collected in both groups after an overnight fast and two hours after the consumption of a standard 300 kcal-mixed meal (Nutridrink, Nutricia).

Results: Mean fasting values of both AG and DAG were significantly lower in the obese individuals. On the other hand, among non-obese controls, the mean postprandial DAG levels did not change and AG levels decreased, whereas in obese individuals the mean DAG levels after a mixed-meal diminished and AG levels were unchanged.

Conclusions: It is necessary to distinguish between the desacylated and acylated forms of ghrelin, as we have shown differential postprandial AG and DAG responses in obese and non-obese individuals. Whether targeting changed proportions between AG and DAG could be a successful strategy in obesity treatment remains a question for future studies. (Endokrynol Pol 2014; 65 (5): 377–381)

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Keywords

desacyl ghrelin; acyl ghrelin; obesity; meals

About this article
Title

Fasting and postprandial acyl and desacyl ghrelin levels in obese and non-obese subjects

Journal

Endokrynologia Polska

Issue

Vol 65, No 5 (2014)

Pages

377-381

Published online

2014-10-09

DOI

10.5603/EP.2014.0052

Bibliographic record

Endokrynologia Polska 2014;65(5):377-381.

Keywords

desacyl ghrelin
acyl ghrelin
obesity
meals

Authors

Jolanta Anna Dardzińska
Sylwia Małgorzewicz
Łukasz Kaska
Monika Proczko
Tomasz Stefaniak
Marta Stankiewicz
Zbigniew Śledziński

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