open access

Vol 66, No 2 (2015)
Original papers
Published online: 2015-05-01
Submitted: 2014-07-06
Accepted: 2014-10-06
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Evaluation of adipocytokines in children with chronic kidney disease

Maria Szczepańska, Edyta Machura, Piotr Adamczyk, Elżbieta Świętochowska, Elżbieta Trembecka-Dubel, Katarzyna Lipiec, Agnieszka Jędzura, Katarzyna Ziora
DOI: 10.5603/EP.2015.0015
·
Endokrynologia Polska 2015;66(2):100-107.

open access

Vol 66, No 2 (2015)
Original papers
Published online: 2015-05-01
Submitted: 2014-07-06
Accepted: 2014-10-06

Abstract

Introduction: Adipose tissue through the many secreted adipocytokines creates a highly active metabolic and endocrine organ. The evaluation
of serum adipocytokine concentration in children with chronic kidney disease (CKD) could serve as a marker of cardio-vascular
complication progression and an index of outcome in adulthood and after kidney transplantation.
Material and methods: The aim of the study was to evaluate simultaneously the serum concentrations of six different adipocytokines:
adiponectin, apelin, chemerin, omentin, resistin, and vaspin, in 28 children with CKD stage 5 on haemodialysis and peritoneal dialysis.
Results: The concentration of apelin, omentin, and resistin in children with CKD was significantly higher and the concentration of
vaspin, adiponectin, and chemerin was significantly lower than in the control group. After adjusting to body mass index (BMI), the same
results were obtained. After adjusting to body surface area (BSA), the concentration of vaspin, adiponectin, and chemerin did not differ
between children with CKD and the control group. In analysis of the correlation between serum total adipocytokine levels in children
with CKD we found a negative relationship in pairs: omentin–apelin and omentin–vaspin, and positive in pairs: adiponectin–chemerin
and adiponectin–resistin.
Conclusions: Our results show that changes in serum adipocytokines concentration are associated with the kidney dysfunction in CKD
in children. Longitudinal studies on larger groups of paediatric cohorts would be helpful in investigating whether adipocytokines play
a harmful role in the development of CKD and would enable further understanding of the risk factors for CKD progression.
(Endokrynol Pol 2015; 66 (2): 100–107)

Abstract

Introduction: Adipose tissue through the many secreted adipocytokines creates a highly active metabolic and endocrine organ. The evaluation
of serum adipocytokine concentration in children with chronic kidney disease (CKD) could serve as a marker of cardio-vascular
complication progression and an index of outcome in adulthood and after kidney transplantation.
Material and methods: The aim of the study was to evaluate simultaneously the serum concentrations of six different adipocytokines:
adiponectin, apelin, chemerin, omentin, resistin, and vaspin, in 28 children with CKD stage 5 on haemodialysis and peritoneal dialysis.
Results: The concentration of apelin, omentin, and resistin in children with CKD was significantly higher and the concentration of
vaspin, adiponectin, and chemerin was significantly lower than in the control group. After adjusting to body mass index (BMI), the same
results were obtained. After adjusting to body surface area (BSA), the concentration of vaspin, adiponectin, and chemerin did not differ
between children with CKD and the control group. In analysis of the correlation between serum total adipocytokine levels in children
with CKD we found a negative relationship in pairs: omentin–apelin and omentin–vaspin, and positive in pairs: adiponectin–chemerin
and adiponectin–resistin.
Conclusions: Our results show that changes in serum adipocytokines concentration are associated with the kidney dysfunction in CKD
in children. Longitudinal studies on larger groups of paediatric cohorts would be helpful in investigating whether adipocytokines play
a harmful role in the development of CKD and would enable further understanding of the risk factors for CKD progression.
(Endokrynol Pol 2015; 66 (2): 100–107)
Get Citation

Keywords

adipocytokines; children; chronic kidney disease; adiponectin; apelin; chemerin; omentin; resistin; vaspin

About this article
Title

Evaluation of adipocytokines in children with chronic kidney disease

Journal

Endokrynologia Polska

Issue

Vol 66, No 2 (2015)

Pages

100-107

Published online

2015-05-01

DOI

10.5603/EP.2015.0015

Bibliographic record

Endokrynologia Polska 2015;66(2):100-107.

Keywords

adipocytokines
children
chronic kidney disease
adiponectin
apelin
chemerin
omentin
resistin
vaspin

Authors

Maria Szczepańska
Edyta Machura
Piotr Adamczyk
Elżbieta Świętochowska
Elżbieta Trembecka-Dubel
Katarzyna Lipiec
Agnieszka Jędzura
Katarzyna Ziora

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