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Pancreatic neuroendocrine neoplasms — management guidelines (recommended by the Polish Network of Neuroendocrine Tumours)
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Abstract
We present revised diagnostic and therapeutic guidelines for the management of pancreatic neuroendocrine neoplasms (PNENs) proposed by the Polish Network of Neuroendocrine Tumours.
These guidelines refer to biochemical (determination of specific and nonspecific neuroendocrine markers) and imaging diagnostics (EUS, CT, MR, and radioisotope examination with a 68Ga or 99Tc labelled somatostatin analogue).
A histopathological diagnostic, which determines the further management of patients with PNENs, must be necessarily confirmed by immunohistochemical tests. PNENs therapy requires collaboration between a multidisciplinary team of specialists experienced in the management of these neoplasms. Surgery is the basic form of treatment. Medical therapy requires a multidirectional procedure, and therefore the rules of biotherapy, peptide receptor radionuclide therapy, chemotherapy and molecular targeted therapy are discussed. (Endokrynol Pol 2013; 64 (6): 459–479)
Abstract
We present revised diagnostic and therapeutic guidelines for the management of pancreatic neuroendocrine neoplasms (PNENs) proposed by the Polish Network of Neuroendocrine Tumours.
These guidelines refer to biochemical (determination of specific and nonspecific neuroendocrine markers) and imaging diagnostics (EUS, CT, MR, and radioisotope examination with a 68Ga or 99Tc labelled somatostatin analogue).
A histopathological diagnostic, which determines the further management of patients with PNENs, must be necessarily confirmed by immunohistochemical tests. PNENs therapy requires collaboration between a multidisciplinary team of specialists experienced in the management of these neoplasms. Surgery is the basic form of treatment. Medical therapy requires a multidirectional procedure, and therefore the rules of biotherapy, peptide receptor radionuclide therapy, chemotherapy and molecular targeted therapy are discussed. (Endokrynol Pol 2013; 64 (6): 459–479)
Keywords
pancreatic neuroendocrine neoplasms; functioning; non-functioning; diagnosis; therapy; guidelines
About this articleTitle
Pancreatic neuroendocrine neoplasms — management guidelines (recommended by the Polish Network of Neuroendocrine Tumours)
Journal
Issue
Article type
Review paper
Pages
459-479
Published online
2013-12-31
Page views
3399
Article views/downloads
3878
DOI
10.5603/EP.2013.0031
Bibliographic record
Endokrynol Pol 2013;64(6):459-479.
Keywords
pancreatic neuroendocrine neoplasms
functioning
non-functioning
diagnosis
therapy
guidelines
Authors
Beata Kos-Kudła
Alicja Hubalewska-Dydejczyk
Katarzyna Kuśnierz
Paweł Lampe
Bogdan Marek
Anna Nasierowska-Guttmejer
Ewa Nowakowska-Duława
Joanna Pilch-Kowalczyk
Anna Sowa-Staszczak
Violetta Rosiek
Other participants of the Consensus Conference (affiliations at the end of this section):
Elżbieta Andrysiak-Mamos
Tomasz Bednarczuk
Jolanta Blicharz-Dorniak
Marek Bolanowski
Andrzej Cichocki
Jarosław B. Ćwikła
Andrzej Deptała
Wanda Foltyn
Daria Handkiewicz-Junak
Marek Hartleb
Michał Jarząb
Arkadiusz Jeziorski
Dariusz Kajdaniuk
Grzegorz Kamiński
Aldona Kowalska
Robert Król
Leszek Królicki
Jolanta Kunikowska
Dariusz Lange
Anna Lewczuk
Magdalena Londzin-Olesik
Przemysław Majewski
Gabriela Mełeń-Mucha
Andrzej Nowak
Waldemar Patkowski
Marek Ruchała
Sławomir Rudzki
Philippe Ruszniewski
Grażyna Rydzewska
Teresa Starzyńska
Katarzyna Steinhof-Radwańska
Janusz Strzelczyk
Wojciech Zajęcki
Piotr Zdunowski
Anna Zemczak
