Vol 64, No 6 (2013)
Review paper
Published online: 2013-12-31

open access

Page views 3939
Article views/downloads 4227
Get Citation

Connect on Social Media

Connect on Social Media

Pancreatic neuroendocrine neoplasms — management guidelines (recommended by the Polish Network of Neuroendocrine Tumours)

Beata Kos-Kudła, Alicja Hubalewska-Dydejczyk, Katarzyna Kuśnierz, Paweł Lampe, Bogdan Marek, Anna Nasierowska-Guttmejer, Ewa Nowakowska-Duława, Joanna Pilch-Kowalczyk, Anna Sowa-Staszczak, Violetta Rosiek, Other participants of the Consensus Conference (affiliations at the end of this section):, Elżbieta Andrysiak-Mamos, Tomasz Bednarczuk, Jolanta Blicharz-Dorniak, Marek Bolanowski, Andrzej Cichocki, Jarosław B. Ćwikła, Andrzej Deptała, Wanda Foltyn, Daria Handkiewicz-Junak, Marek Hartleb, Michał Jarząb, Arkadiusz Jeziorski, Dariusz Kajdaniuk, Grzegorz Kamiński, Aldona Kowalska, Robert Król, Leszek Królicki, Jolanta Kunikowska, Dariusz Lange, Anna Lewczuk, Magdalena Londzin-Olesik, Przemysław Majewski, Gabriela Mełeń-Mucha, Andrzej Nowak, Waldemar Patkowski, Marek Ruchała, Sławomir Rudzki, Philippe Ruszniewski, Grażyna Rydzewska, Teresa Starzyńska, Katarzyna Steinhof-Radwańska, Janusz Strzelczyk, Wojciech Zajęcki, Piotr Zdunowski, Anna Zemczak
DOI: 10.5603/EP.2013.0031
Endokrynol Pol 2013;64(6):459-479.

Abstract

We present revised diagnostic and therapeutic guidelines for the management of pancreatic neuroendocrine neoplasms (PNENs) proposed by the Polish Network of Neuroendocrine Tumours.

These guidelines refer to biochemical (determination of specific and nonspecific neuroendocrine markers) and imaging diagnostics (EUS, CT, MR, and radioisotope examination with a 68Ga or 99Tc labelled somatostatin analogue).

A histopathological diagnostic, which determines the further management of patients with PNENs, must be necessarily confirmed by immunohistochemical tests. PNENs therapy requires collaboration between a multidisciplinary team of specialists experienced in the management of these neoplasms. Surgery is the basic form of treatment. Medical therapy requires a multidirectional procedure, and therefore the rules of biotherapy, peptide receptor radionuclide therapy, chemotherapy and molecular targeted therapy are discussed. (Endokrynol Pol 2013; 64 (6): 459–479)