open access

Vol 65, No 6 (2014)
Original papers
Published online: 2014-12-31
Submitted: 2013-12-16
Accepted: 2014-07-03
Get Citation

Treatment with statins and testosterone levels in men

Marek Mędraś, Eliza Kubicka, Paweł Jóźkow, Małgorzata Słowińska-Lisowska, Anna Trzmiel-Bira, Alicja Filus
DOI: 10.5603/EP.2014.0064
·
Endokrynologia Polska 2014;65(6):464-468.

open access

Vol 65, No 6 (2014)
Original papers
Published online: 2014-12-31
Submitted: 2013-12-16
Accepted: 2014-07-03

Abstract

Introduction: Statins belong to the most commonly used medicines worldwide. They affect cholesterol synthesis and thus they may suppress steroidogenesis. Our aim was to evaluate whether the use of statins is associated with the concentration of sex hormones.

Material and methods/Results: In a population sample of men (n = 237) we found that subjects receiving statins had significantly lower concentrations of: total testosterone (14.9 vs. 16.35 nmol/L, p = 0.008 after correction for body mass), free testosterone (32 vs. 39 pmol/L, p = 0.004), calculated free testosterone (0.32 vs. 0.36 nmol/L, p < 0.001) and bioavailable testosterone (6.10 vs. 7.56 nmol/L, p < 0.001) than age-matched controls.

Conclusions: We conclude that the use of statins may have an impact on the diagnosis of age-related testosterone deficiency in men. (Endokrynol Pol 2014; 65 (6): 464–468)

Abstract

Introduction: Statins belong to the most commonly used medicines worldwide. They affect cholesterol synthesis and thus they may suppress steroidogenesis. Our aim was to evaluate whether the use of statins is associated with the concentration of sex hormones.

Material and methods/Results: In a population sample of men (n = 237) we found that subjects receiving statins had significantly lower concentrations of: total testosterone (14.9 vs. 16.35 nmol/L, p = 0.008 after correction for body mass), free testosterone (32 vs. 39 pmol/L, p = 0.004), calculated free testosterone (0.32 vs. 0.36 nmol/L, p < 0.001) and bioavailable testosterone (6.10 vs. 7.56 nmol/L, p < 0.001) than age-matched controls.

Conclusions: We conclude that the use of statins may have an impact on the diagnosis of age-related testosterone deficiency in men. (Endokrynol Pol 2014; 65 (6): 464–468)

Get Citation

Keywords

hydroxymethylglutaryl-CoA reductase inhibitors; steroid hormones; testosterone; men

About this article
Title

Treatment with statins and testosterone levels in men

Journal

Endokrynologia Polska

Issue

Vol 65, No 6 (2014)

Pages

464-468

Published online

2014-12-31

DOI

10.5603/EP.2014.0064

Bibliographic record

Endokrynologia Polska 2014;65(6):464-468.

Keywords

hydroxymethylglutaryl-CoA reductase inhibitors
steroid hormones
testosterone
men

Authors

Marek Mędraś
Eliza Kubicka
Paweł Jóźkow
Małgorzata Słowińska-Lisowska
Anna Trzmiel-Bira
Alicja Filus

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