open access

Vol 64, No 4 (2013)
Original papers
Published online: 2013-09-04
Submitted: 2013-09-04
Accepted: 2013-09-04
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Placental growth hormone, pituitary growth hormone, insulin-like growth factor, and ghrelin in umbilical cord blood serum and amniotic fluid

Andrzej Kędzia, Elżbieta Petriczko, Agata Tarka
DOI: 10.5603/EP.2013.0008
·
Endokrynologia Polska 2013;64(4):293-299.

open access

Vol 64, No 4 (2013)
Original papers
Published online: 2013-09-04
Submitted: 2013-09-04
Accepted: 2013-09-04

Abstract

Introduction: In the search for biomarkers that allow the prediction of neonatal growth and development, placental growth hormone(PGH), pituitary growth hormone (GH1), insulin-like growth factor 1 (IGF-1), and ghrelin concentrations were assessed in the amnioticfluid and in the umbilical cord blood of 92 neonates.

Material and methods: The proteins were assayed by the ELISA method. Their concentration values were compared in 57 full-termneonates and 35 prematurely born neonates, as well as in both large (> 4,000 g) and small neonates (< 2,500 g). Also, body mass andplacenta mass were compared.

Results: Statistically significant differences both between prematurely born neonates and full-term neonates and between large andsmall neonates were obtained only in terms of the body mass of neonates and placenta mass. The concentration values of the hormonesstudied did not show statistically significant differences. A distinct tendency was noticed towards an increase in PGH concentration inboth prematurely born and small neonates. In large neonates, statistically significantly higher IGF-1 concentrations were found comparedto the prematurely born neonates.

Conclusions: Our studies indicate an important role for PGH in maintaining a proper IGF-1 pool and demonstrate the existence ofa direct influence on the function of the placenta in prematurely born neonates through the activation of compensation mechanisms,which stimulate IGF-1 synthesis.

Abstract

Introduction: In the search for biomarkers that allow the prediction of neonatal growth and development, placental growth hormone(PGH), pituitary growth hormone (GH1), insulin-like growth factor 1 (IGF-1), and ghrelin concentrations were assessed in the amnioticfluid and in the umbilical cord blood of 92 neonates.

Material and methods: The proteins were assayed by the ELISA method. Their concentration values were compared in 57 full-termneonates and 35 prematurely born neonates, as well as in both large (> 4,000 g) and small neonates (< 2,500 g). Also, body mass andplacenta mass were compared.

Results: Statistically significant differences both between prematurely born neonates and full-term neonates and between large andsmall neonates were obtained only in terms of the body mass of neonates and placenta mass. The concentration values of the hormonesstudied did not show statistically significant differences. A distinct tendency was noticed towards an increase in PGH concentration inboth prematurely born and small neonates. In large neonates, statistically significantly higher IGF-1 concentrations were found comparedto the prematurely born neonates.

Conclusions: Our studies indicate an important role for PGH in maintaining a proper IGF-1 pool and demonstrate the existence ofa direct influence on the function of the placenta in prematurely born neonates through the activation of compensation mechanisms,which stimulate IGF-1 synthesis.

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Keywords

PGH, GH1, IGF-1, ghrelin, neonate, umbilical cord blood serum, amniotic fluid

About this article
Title

Placental growth hormone, pituitary growth hormone, insulin-like growth factor, and ghrelin in umbilical cord blood serum and amniotic fluid

Journal

Endokrynologia Polska

Issue

Vol 64, No 4 (2013)

Pages

293-299

Published online

2013-09-04

DOI

10.5603/EP.2013.0008

Bibliographic record

Endokrynologia Polska 2013;64(4):293-299.

Keywords

PGH
GH1
IGF-1
ghrelin
neonate
umbilical cord blood serum
amniotic fluid

Authors

Andrzej Kędzia
Elżbieta Petriczko
Agata Tarka

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