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Vol 64, No 3 (2013)
Review paper
Submitted: 2013-07-31
Published online: 2013-07-01
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Can we accurately measure the concentration of clinically relevant vitamin D metabolites in the circulation? The problems and their consequences

Zbigniew Bartoszewicz, Agnieszka Kondracka, Radosław Jaźwiec, Michał Popow, Michał Dadlez, Tomasz Bednarczuk
Endokrynol Pol 2013;64(3):238-245.

open access

Vol 64, No 3 (2013)
Reviews — Postgraduate Education
Submitted: 2013-07-31
Published online: 2013-07-01

Abstract

Increased interest in vitamin D measurements in clinical studies has contributed to the development in recent years of several new immunochemical assays (manual and for automatic analyzers). New methods, including HPLC (high performance liquid chromatography), and LC-MS/MS (liquid chromatography coupled with tandem mass spectrometry) have also been introduced into routine diagnostic laboratories. Because of the variety of assays and methods used, the question arises which one is the most accurate for the measurement of vitamin D metabolites concentration. In this review, we summarise the advantages and disadvantages of these methods, describe the complexity of vitamin D metabolites pattern in the circulation, and discuss the problem of accurate measuring its concentration. (Endokrynol Pol 2013; 64 (3): 238–245)

Abstract

Increased interest in vitamin D measurements in clinical studies has contributed to the development in recent years of several new immunochemical assays (manual and for automatic analyzers). New methods, including HPLC (high performance liquid chromatography), and LC-MS/MS (liquid chromatography coupled with tandem mass spectrometry) have also been introduced into routine diagnostic laboratories. Because of the variety of assays and methods used, the question arises which one is the most accurate for the measurement of vitamin D metabolites concentration. In this review, we summarise the advantages and disadvantages of these methods, describe the complexity of vitamin D metabolites pattern in the circulation, and discuss the problem of accurate measuring its concentration. (Endokrynol Pol 2013; 64 (3): 238–245)

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Keywords

vitamin D; calcidiol; calcitriol; immunoassays; LC-MS/MS

About this article
Title

Can we accurately measure the concentration of clinically relevant vitamin D metabolites in the circulation? The problems and their consequences

Journal

Endokrynologia Polska

Issue

Vol 64, No 3 (2013)

Article type

Review paper

Pages

238-245

Published online

2013-07-01

Page views

865

Article views/downloads

4822

Bibliographic record

Endokrynol Pol 2013;64(3):238-245.

Keywords

vitamin D
calcidiol
calcitriol
immunoassays
LC-MS/MS

Authors

Zbigniew Bartoszewicz
Agnieszka Kondracka
Radosław Jaźwiec
Michał Popow
Michał Dadlez
Tomasz Bednarczuk

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