open access

Vol 64, No 3 (2013)
Original papers
Published online: 2013-07-01
Submitted: 2013-07-31
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Serum sex hormone binding globulin profile and its association with insulin resistance in Chinese peri-menopausal women

Yu Hong, Dongmei Chen, Yangzhi Li, Chunhua Li, Ying Liu, Meiqing Xie
Endokrynologia Polska 2013;64(3):197-202.

open access

Vol 64, No 3 (2013)
Original papers
Published online: 2013-07-01
Submitted: 2013-07-31

Abstract


Introduction: The aim of this study was to measure serum sex hormone binding globulin (SHBG) profile in Chinese peri-menopausal women, and assess its correlation with insulin resistance (IR)-related parameter, namely HOMA-IR, in this special population.
Material and methods: A cross-sectional study by the method of cluster sampling was performed in 1,827 women, who were in hospital for routine check-up. Serum SHBG profile and anthropometric indices of hormonal, adiposity, and metabolic variables were measured. According to their age and menstruation status, the subjects were divided into three groups: pre-menopause group, peri-menopause group, and post-menopause group.
Results: Serum SHBG level was found to be negatively correlated with BMI in all groups and to increase in parallel with age in women of reproductive age. However, independently of age, it significantly increased from the onset of menopause transition, and slightly declined after menopause. After adjustment for age and BMI, HOMA-IR in peri-menopausal women was closely related only to SHBG. SHBG level was found to be the only independent significant determinant of HOMA-IR. On the basis of ROC curve analysis for the prediction of insulin resistance using HOMA-IR value, AUC for SHBG reached a value of 0.816 (0.636–0.996, 95% confidence interval). The best cutoff value that discriminates peri-menopausal women with or without insulin resistance is 41.73 nmol/L, with a sensitivity of 81.4% and a specificity of 87.5%.
Conclusions: Low SHBG level may be an independent risk factor of insulin resistance in Chinese peri-menopausal women. (Endokrynol Pol 2013; 64 (3): 197–202)

Abstract


Introduction: The aim of this study was to measure serum sex hormone binding globulin (SHBG) profile in Chinese peri-menopausal women, and assess its correlation with insulin resistance (IR)-related parameter, namely HOMA-IR, in this special population.
Material and methods: A cross-sectional study by the method of cluster sampling was performed in 1,827 women, who were in hospital for routine check-up. Serum SHBG profile and anthropometric indices of hormonal, adiposity, and metabolic variables were measured. According to their age and menstruation status, the subjects were divided into three groups: pre-menopause group, peri-menopause group, and post-menopause group.
Results: Serum SHBG level was found to be negatively correlated with BMI in all groups and to increase in parallel with age in women of reproductive age. However, independently of age, it significantly increased from the onset of menopause transition, and slightly declined after menopause. After adjustment for age and BMI, HOMA-IR in peri-menopausal women was closely related only to SHBG. SHBG level was found to be the only independent significant determinant of HOMA-IR. On the basis of ROC curve analysis for the prediction of insulin resistance using HOMA-IR value, AUC for SHBG reached a value of 0.816 (0.636–0.996, 95% confidence interval). The best cutoff value that discriminates peri-menopausal women with or without insulin resistance is 41.73 nmol/L, with a sensitivity of 81.4% and a specificity of 87.5%.
Conclusions: Low SHBG level may be an independent risk factor of insulin resistance in Chinese peri-menopausal women. (Endokrynol Pol 2013; 64 (3): 197–202)
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Keywords

sex hormone binding globulin (SHBG); peri-menopause; insulin resistance; predictive value

About this article
Title

Serum sex hormone binding globulin profile and its association with insulin resistance in Chinese peri-menopausal women

Journal

Endokrynologia Polska

Issue

Vol 64, No 3 (2013)

Pages

197-202

Published online

2013-07-01

Bibliographic record

Endokrynologia Polska 2013;64(3):197-202.

Keywords

sex hormone binding globulin (SHBG)
peri-menopause
insulin resistance
predictive value

Authors

Yu Hong
Dongmei Chen
Yangzhi Li
Chunhua Li
Ying Liu
Meiqing Xie

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