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Assessment of bone metabolism in premenopausal females with hyperthyroidism and hypothyroidism
open access
Abstract
Material and methods: 38 women with hyperthyroidism, 40 with hypothyroidism and 41 healthy women participated in this study. Initially after 6 and 12 months, each patient underwent selected hormonal, immunological and biochemical tests, measurement of concentrations of bone turnover markers and densitometry were also performed.
Results: On initial evaluation, lower cortical bone density was found in patients with hyperthyroidism (femoral neck). After 12 months, an increase in BMD was seen, but it was still lower than in the control group. Statistically significantly higher concentrations of bone turnover markers, decreasing from the sixth month of treatment, were noted only in the group with hyperthyroidism. Statistically significant differences were not noted in the femoral neck nor in the lumbar spine BMD in patients with hypothyroidism.
Conclusions: Hyperthyroidism poses a negative effect on bone metabolism. Hypothyroidism in premenopausal females does not have any influence on bone density.
Abstract
Material and methods: 38 women with hyperthyroidism, 40 with hypothyroidism and 41 healthy women participated in this study. Initially after 6 and 12 months, each patient underwent selected hormonal, immunological and biochemical tests, measurement of concentrations of bone turnover markers and densitometry were also performed.
Results: On initial evaluation, lower cortical bone density was found in patients with hyperthyroidism (femoral neck). After 12 months, an increase in BMD was seen, but it was still lower than in the control group. Statistically significantly higher concentrations of bone turnover markers, decreasing from the sixth month of treatment, were noted only in the group with hyperthyroidism. Statistically significant differences were not noted in the femoral neck nor in the lumbar spine BMD in patients with hypothyroidism.
Conclusions: Hyperthyroidism poses a negative effect on bone metabolism. Hypothyroidism in premenopausal females does not have any influence on bone density.
Keywords
hyperthyroidism; hypothyroidism; bone mineral density (BMD); osteocalcin (OC); collagen type 1 crosslinked C-telopeptides (CTx)
About this articleTitle
Assessment of bone metabolism in premenopausal females with hyperthyroidism and hypothyroidism
Journal
Issue
Article type
Original paper
Pages
40-44
Published online
2013-02-28
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643
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2129
Bibliographic record
Endokrynol Pol 2013;64(1):40-44.
Keywords
hyperthyroidism
hypothyroidism
bone mineral density (BMD)
osteocalcin (OC)
collagen type 1 crosslinked C-telopeptides (CTx)
Authors
Dominika Tuchendler
Marek Bolanowski
