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Relationships between adiponectin, sex hormone binding globulin and insulin resistance in hyperthyroid Graves’ disease women
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Abstract
Material and methods: The study was undertaken in 60 women with hyperthyroidism in the course of GD; 32 healthy women matched by BMI and age formed the control group. The concentrations of: free thyroxine (fT4), free triiodothyronine (fT3), thyroid-stimulating hormone (TSH), SHBG, insulin, adiponectin and glucose were measured, and the homeostasis model assessment (HOMA-I) was calculated.
Results: Compared to euthyroid subjects, hyperthyroid GD women had elevated glucose, fT4, fT3, adiponectin and SHBG concentrations, but there were no differences in HOMA-I. When we explored the relations between adiponectin as well as SHBG with glucose and HOMA-I, we observed that HOMA-I was associated with adiponectin and SHBG only in the control group, and in hyperthyroidism there were no such connections. We found positive associations between adiponectin, SHBG, fT4 and fT3 in the GD group.
Conclusions: Elevated concentrations of adiponectin and SHBG were observed in hyperthyroidism but they were not related to insulin resistance.
Abstract
Material and methods: The study was undertaken in 60 women with hyperthyroidism in the course of GD; 32 healthy women matched by BMI and age formed the control group. The concentrations of: free thyroxine (fT4), free triiodothyronine (fT3), thyroid-stimulating hormone (TSH), SHBG, insulin, adiponectin and glucose were measured, and the homeostasis model assessment (HOMA-I) was calculated.
Results: Compared to euthyroid subjects, hyperthyroid GD women had elevated glucose, fT4, fT3, adiponectin and SHBG concentrations, but there were no differences in HOMA-I. When we explored the relations between adiponectin as well as SHBG with glucose and HOMA-I, we observed that HOMA-I was associated with adiponectin and SHBG only in the control group, and in hyperthyroidism there were no such connections. We found positive associations between adiponectin, SHBG, fT4 and fT3 in the GD group.
Conclusions: Elevated concentrations of adiponectin and SHBG were observed in hyperthyroidism but they were not related to insulin resistance.
Keywords
hyperthyroidism; insulin resistance; adiponectin; SHBG
About this articleTitle
Relationships between adiponectin, sex hormone binding globulin and insulin resistance in hyperthyroid Graves’ disease women
Journal
Issue
Article type
Original paper
Pages
26-29
Published online
2013-02-28
Page views
673
Article views/downloads
2291
Bibliographic record
Endokrynol Pol 2013;64(1):26-29.
Keywords
hyperthyroidism
insulin resistance
adiponectin
SHBG
Authors
Lucyna Siemińska
Wanda Foltyn
Joanna Głogowska-Szeląg
Dariusz Kajdaniuk
Bogdan Marek
Mariusz Nowak
Krzysztof Walczak
Beata Kos-Kudła
