open access

Vol 64, No 2 (2013)
Original papers
Published online: 2013-04-30
Submitted: 2013-05-14
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The reference values of sex hormones and SHBG serum levels in subjects over 65 years old — The PolSenior Study

Andrzej Milewicz, Barbara Krzyżanowska-Świniarska, Tomasz Miazgowski, Diana Jędrzejuk, Anna Arkowska, Urszula Mieszczanowicz, Ewa Bar-Andziak
Endokrynologia Polska 2013;64(2):82-93.

open access

Vol 64, No 2 (2013)
Original papers
Published online: 2013-04-30
Submitted: 2013-05-14

Abstract


Introduction: Over the last decade, average life expectancy has continuously increased. There has been no data on normal sex hormone (SH) levels in a Polish elderly population. In this study, we assessed SH in the PolSenior cohort to determine normal reference ranges in relation to gender, age, and cardiovascular disease risk factors (CVDRFs).
Material and methods: The study was performed with 4,352 participants (2,168 men and 2,088 women), aged from 55 to over 90 years, stratified in five-year age groups. Pre-elderly subjects (55–59 years of age) served as the reference group. We assessed total testosterone (TT), estradiol (TE2) and DHEA-S (by RIA) SHBG and FSH (by IRMA) and calculated free androgen and free estrogen indices (FAI and FEI). Percentage body fat (%BF) was measured by bioelectric impedance analysis. The CVDRFs assessment included blood pressure and biochemical (blood glucose, high-density lipoproteins, triglycerides) and anthropometric (waist circumference) components of the metabolic syndrome.
Results: TT was low in 19.9%, normal in 78.2%, and high in 1.8% of men. TE2 was low in 94.6% of women. Age and CVDRFs significantly influenced values of SHBG, FSH, TT, FAI, FEI, and DHEA-S in men, while in women values of FSH, TT and TE2 did not change. BMI and %BF affected SH regardless of the age groups and CVDRFs.
Conclusions: Our findings suggest that the reference ranges stratified by the five-year age bands seem more accurate than those given for the overall population over 60 years of age. The clinical relevance of these reference ranges increases when they are considered in relation to CVDRFs, BMI and %BF. (Endokrynol Pol 2013; 64 (2): 82–93)

Abstract


Introduction: Over the last decade, average life expectancy has continuously increased. There has been no data on normal sex hormone (SH) levels in a Polish elderly population. In this study, we assessed SH in the PolSenior cohort to determine normal reference ranges in relation to gender, age, and cardiovascular disease risk factors (CVDRFs).
Material and methods: The study was performed with 4,352 participants (2,168 men and 2,088 women), aged from 55 to over 90 years, stratified in five-year age groups. Pre-elderly subjects (55–59 years of age) served as the reference group. We assessed total testosterone (TT), estradiol (TE2) and DHEA-S (by RIA) SHBG and FSH (by IRMA) and calculated free androgen and free estrogen indices (FAI and FEI). Percentage body fat (%BF) was measured by bioelectric impedance analysis. The CVDRFs assessment included blood pressure and biochemical (blood glucose, high-density lipoproteins, triglycerides) and anthropometric (waist circumference) components of the metabolic syndrome.
Results: TT was low in 19.9%, normal in 78.2%, and high in 1.8% of men. TE2 was low in 94.6% of women. Age and CVDRFs significantly influenced values of SHBG, FSH, TT, FAI, FEI, and DHEA-S in men, while in women values of FSH, TT and TE2 did not change. BMI and %BF affected SH regardless of the age groups and CVDRFs.
Conclusions: Our findings suggest that the reference ranges stratified by the five-year age bands seem more accurate than those given for the overall population over 60 years of age. The clinical relevance of these reference ranges increases when they are considered in relation to CVDRFs, BMI and %BF. (Endokrynol Pol 2013; 64 (2): 82–93)
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Keywords

testosterone; estradiol; indices of free sex hormones; SHBG; DHEA-S; elderly people; reference values

About this article
Title

The reference values of sex hormones and SHBG serum levels in subjects over 65 years old — The PolSenior Study

Journal

Endokrynologia Polska

Issue

Vol 64, No 2 (2013)

Pages

82-93

Published online

2013-04-30

Bibliographic record

Endokrynologia Polska 2013;64(2):82-93.

Keywords

testosterone
estradiol
indices of free sex hormones
SHBG
DHEA-S
elderly people
reference values

Authors

Andrzej Milewicz
Barbara Krzyżanowska-Świniarska
Tomasz Miazgowski
Diana Jędrzejuk
Anna Arkowska
Urszula Mieszczanowicz
Ewa Bar-Andziak

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