open access

Vol 56, No 1 (2005)
Original papers
Published online: 2006-03-22
Submitted: 2013-02-15
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Serum leptin and adiponectin concentrations in patients infected with human immunodeficiency virus type 1 (HIV-1) on antiretroviral therapy

Magdalena Leszczyszyn-Pynka, Sławomir Pynka, Anna Boroń-Kaczmarska, Krystyna Pilarska
Endokrynologia Polska 2005;56(1):19-24.

open access

Vol 56, No 1 (2005)
Original papers
Published online: 2006-03-22
Submitted: 2013-02-15

Abstract

The lipodystrophy syndrome with dyslipidaemia and insuline resistance is side-effect of combined antiretroviral therapy (CART).
Aim of the study: to describe the influence of CART on leptin and adiponectin concentration in connection with lipids levels in HIV-infected patients on antiretroviral therapy.
BMI, serum leptin, adiponectin, triglycerides, total cholesterol, HDL- and LDL-cholesterol concentrations were measured in 56 HIV(+) patients before and on CART; average of treatment duration 38.4 ± 13.2 months. Significant increase of BMI (p=0.0268) of (22.6 ± 3.3 before and 23.5 ± 3.4 kg/m2 on therapy, respectively) and all analyzed lipids were found. Mean adiponectin concentration in treated patients was significantly (7.256 ± 3.551 µg/ml) lower than mean value before treatment (8.395 ± 3.568 µg/ml; p=0.0011). Mean values of leptin concentrations did not differ significantly (before therapy 3.721 ± 0.347 log10; on therapy 3.1737 ± 0.353 log10). Significant positive correlation between BMI and leptin concentrations was found before, as well as during CART (r=0.5333; p

Abstract

The lipodystrophy syndrome with dyslipidaemia and insuline resistance is side-effect of combined antiretroviral therapy (CART).
Aim of the study: to describe the influence of CART on leptin and adiponectin concentration in connection with lipids levels in HIV-infected patients on antiretroviral therapy.
BMI, serum leptin, adiponectin, triglycerides, total cholesterol, HDL- and LDL-cholesterol concentrations were measured in 56 HIV(+) patients before and on CART; average of treatment duration 38.4 ± 13.2 months. Significant increase of BMI (p=0.0268) of (22.6 ± 3.3 before and 23.5 ± 3.4 kg/m2 on therapy, respectively) and all analyzed lipids were found. Mean adiponectin concentration in treated patients was significantly (7.256 ± 3.551 µg/ml) lower than mean value before treatment (8.395 ± 3.568 µg/ml; p=0.0011). Mean values of leptin concentrations did not differ significantly (before therapy 3.721 ± 0.347 log10; on therapy 3.1737 ± 0.353 log10). Significant positive correlation between BMI and leptin concentrations was found before, as well as during CART (r=0.5333; p
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Keywords

HIV; antiretroviral therapy; metabolic disorders; leptin; adiponectin

About this article
Title

Serum leptin and adiponectin concentrations in patients infected with human immunodeficiency virus type 1 (HIV-1) on antiretroviral therapy

Journal

Endokrynologia Polska

Issue

Vol 56, No 1 (2005)

Pages

19-24

Published online

2006-03-22

Bibliographic record

Endokrynologia Polska 2005;56(1):19-24.

Keywords

HIV
antiretroviral therapy
metabolic disorders
leptin
adiponectin

Authors

Magdalena Leszczyszyn-Pynka
Sławomir Pynka
Anna Boroń-Kaczmarska
Krystyna Pilarska

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