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The influence of thyroid hormones on homocysteine and atherosclerotic vascular disease
open access
Abstract
In hypothyroid condition the hepatic activity of flavoenzyme - MTHFR, is decreased. Thyroid hormone may affect the availability of FMN and FAD - necessary for stabilizing MTHFR. An impairment of enzyme involved in transsulfuration pathway is suggested. The increased serum creatinine level in hypothyroidism probably reflects a reduced glomerular filtration rate, which is linked to impaired renal homocysteine clearance and hyperhomocysteinemia.
Abstract
In hypothyroid condition the hepatic activity of flavoenzyme - MTHFR, is decreased. Thyroid hormone may affect the availability of FMN and FAD - necessary for stabilizing MTHFR. An impairment of enzyme involved in transsulfuration pathway is suggested. The increased serum creatinine level in hypothyroidism probably reflects a reduced glomerular filtration rate, which is linked to impaired renal homocysteine clearance and hyperhomocysteinemia.
Keywords
homocysteine; hypothyroidism; atherosclerosis
Title
The influence of thyroid hormones on homocysteine and atherosclerotic vascular disease
Journal
Issue
Article type
Review paper
Pages
194-202
Published online
2006-03-24
Page views
1403
Article views/downloads
2644
Bibliographic record
Endokrynol Pol 2005;56(2):194-202.
Keywords
homocysteine
hypothyroidism
atherosclerosis
Authors
Anna Orzechowska-Pawiłojć
Anna Lewczuk
Krzysztof Sworczak