Vol 56, No 3 (2005)
Other materials agreed with the Editors
Submitted: 2013-02-15
Published online: 2006-03-24
Membrane receptors for estradiol - new way of biological action
Agnieszka Lachowicz-Ochędalska
Endokrynol Pol 2005;56(3):322-326.
Vol 56, No 3 (2005)
Congressional papers
Submitted: 2013-02-15
Published online: 2006-03-24
Abstract
Classical action of steroid hormones, called genomic, includes binding to their intracellular receptor, require hours or days to occur and require transcriptional effects with subsequent modulation of protein expression. Some of the biological effects induced by steroids, and mainly by sex steroids, take place within seconds or few minutes, time far too fast to be due to the genomic changes. The rapid, nongenomic action of estradiol are attributed to membrane action, probably through variety of proteins present in cell membrane. The rapid effects of steroid hormones are manifold, ranging from activation of protein and tyrosine kinases, G proteins, and modulation of ion channels. The nongenomic way of action includes also non-direct control of processes of transcription and gene expression. There are at least three different way to interact with cell membrane. Steroids may change membrane fluidity, without binding to any known protein or receptor. Another way is allosteric modulation of non-specific for steroid hormones receptors, or structural and enzymatic protein present in cell membrane. Evidence suggests that the classical steroid receptors can be localized at the plasma membrane, triggering signals typical for G-proteins coupled receptors. Physiological significance of nongenomic action of steroids needs to be elucidated.
Abstract
Classical action of steroid hormones, called genomic, includes binding to their intracellular receptor, require hours or days to occur and require transcriptional effects with subsequent modulation of protein expression. Some of the biological effects induced by steroids, and mainly by sex steroids, take place within seconds or few minutes, time far too fast to be due to the genomic changes. The rapid, nongenomic action of estradiol are attributed to membrane action, probably through variety of proteins present in cell membrane. The rapid effects of steroid hormones are manifold, ranging from activation of protein and tyrosine kinases, G proteins, and modulation of ion channels. The nongenomic way of action includes also non-direct control of processes of transcription and gene expression. There are at least three different way to interact with cell membrane. Steroids may change membrane fluidity, without binding to any known protein or receptor. Another way is allosteric modulation of non-specific for steroid hormones receptors, or structural and enzymatic protein present in cell membrane. Evidence suggests that the classical steroid receptors can be localized at the plasma membrane, triggering signals typical for G-proteins coupled receptors. Physiological significance of nongenomic action of steroids needs to be elucidated.
Keywords
estradiol; steroid hormones; membrane receptors; intracellular receptors; genomic action; nongenomic action
Title
Membrane receptors for estradiol - new way of biological action
Journal
Endokrynologia Polska
Issue
Vol 56, No 3 (2005)
Article type
Other materials agreed with the Editors
Pages
322-326
Published online
2006-03-24
Page views
537
Article views/downloads
4988
Bibliographic record
Endokrynol Pol 2005;56(3):322-326.
Keywords
estradiol
steroid hormones
membrane receptors
intracellular receptors
genomic action
nongenomic action
Authors
Agnieszka Lachowicz-Ochędalska
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