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The effects of growth hormone treatment in patients with somatotropin deficiency during their developmental age
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Abstract
Material and methods A total of 117 children and adolescent of both sexes, aged 4.6 to 18.1 years, with diagnosed somatotropic or multihormonal pituitary insufficiency were included in the study. All of them were treated with growth hormone and had an analysis of growth rate and end height.
ResultsIn the first 6 months of growth hormone treatment the growth rate achieved 10.4 cm/year in boys and 10.0 in girls and showed no correlation with maturation status. In the second half of the year the growth rate declined slightly. During the remainder of the therapy the growth rate markedly declined, and this effect was most notable in girls. In 93% of patients after the end of therapy the final height was no different than the expected height.
Conclusions 1. The growth rate in first half a year of the treatment was 3 times higher than before the beginning of therapy. 2. In the second half of the first year the growth rate slightly declined. 3. In following years the growth rate declined notably. 4. The final achieved height in most of the patients does not differ from the prognosed height.
Abstract
Material and methods A total of 117 children and adolescent of both sexes, aged 4.6 to 18.1 years, with diagnosed somatotropic or multihormonal pituitary insufficiency were included in the study. All of them were treated with growth hormone and had an analysis of growth rate and end height.
ResultsIn the first 6 months of growth hormone treatment the growth rate achieved 10.4 cm/year in boys and 10.0 in girls and showed no correlation with maturation status. In the second half of the year the growth rate declined slightly. During the remainder of the therapy the growth rate markedly declined, and this effect was most notable in girls. In 93% of patients after the end of therapy the final height was no different than the expected height.
Conclusions 1. The growth rate in first half a year of the treatment was 3 times higher than before the beginning of therapy. 2. In the second half of the first year the growth rate slightly declined. 3. In following years the growth rate declined notably. 4. The final achieved height in most of the patients does not differ from the prognosed height.
Keywords
growth hormone; growth hormone deficit; growth hormone therapy; growth rate; final height


Title
The effects of growth hormone treatment in patients with somatotropin deficiency during their developmental age
Journal
Issue
Article type
Original paper
Pages
246-251
Published online
2006-03-24
Page views
403
Article views/downloads
1412
Bibliographic record
Endokrynol Pol 2005;56(3):246-251.
Keywords
growth hormone
growth hormone deficit
growth hormone therapy
growth rate
final height
Authors
Andrzej Kędzia
Eugeniusz Korman
Monika Obara-Moszyńska
Barbara Rabska-Pietrzak