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Vol 56, No 3 (2005)
Original paper
Submitted: 2013-02-15
Published online: 2006-03-24
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Polymorphism of VDR gene - the most effective molecular marker of osteoporotic bone fractures risk within postmenopausal women from Wielkopolska region of Poland

Wanda Horst-Sikorska, Anna Wawrzyniak, Liliana Celczyńska-Bajew, Michalina Marcinkowska, Sebastian Dąbrowski, Robert Kalak, Ryszard Słomski
DOI: 10.5603/ep.25857
·
Endokrynol Pol 2005;56(3):233-239.

open access

Vol 56, No 3 (2005)
Original Paper
Submitted: 2013-02-15
Published online: 2006-03-24

Abstract

The major public health problem which will arise is a frequency of osteoporosis. The first manifestations of this disease are often bone fractures. Identification and evaluation of individual bone fracture risk will be the most effective way of solving the problem. Genetic determination of osteoporosis is unquestionable. The aim of this study is to detect which variants of genotypes lead to illness. We investigated 187 patients with osteoporosis (161 women, 26 men) and 19 healthy subjects. Polymorphisms of the following genes were investigated: OPG, VDR, ESR1, TGFB1 COL1A1, and BMP2. The statistically significant relationship between BMD value and T allele of Taq I VDR gene were found. Genotypes: aa, bb, TT of VDR gene occur more frequently in polish osteoporotic population in Wielkopolska region within patients with higher risk of bone fractures.

Abstract

The major public health problem which will arise is a frequency of osteoporosis. The first manifestations of this disease are often bone fractures. Identification and evaluation of individual bone fracture risk will be the most effective way of solving the problem. Genetic determination of osteoporosis is unquestionable. The aim of this study is to detect which variants of genotypes lead to illness. We investigated 187 patients with osteoporosis (161 women, 26 men) and 19 healthy subjects. Polymorphisms of the following genes were investigated: OPG, VDR, ESR1, TGFB1 COL1A1, and BMP2. The statistically significant relationship between BMD value and T allele of Taq I VDR gene were found. Genotypes: aa, bb, TT of VDR gene occur more frequently in polish osteoporotic population in Wielkopolska region within patients with higher risk of bone fractures.

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Keywords

osteoporosis; bone fractures; gene polymorphisms

About this article
Title

Polymorphism of VDR gene - the most effective molecular marker of osteoporotic bone fractures risk within postmenopausal women from Wielkopolska region of Poland

Journal

Endokrynologia Polska

Issue

Vol 56, No 3 (2005)

Article type

Original paper

Pages

233-239

Published online

2006-03-24

Page views

535

Article views/downloads

1942

DOI

10.5603/ep.25857

Bibliographic record

Endokrynol Pol 2005;56(3):233-239.

Keywords

osteoporosis
bone fractures
gene polymorphisms

Authors

Wanda Horst-Sikorska
Anna Wawrzyniak
Liliana Celczyńska-Bajew
Michalina Marcinkowska
Sebastian Dąbrowski
Robert Kalak
Ryszard Słomski

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