Vol 56, No 6 (2005)
Review paper
Submitted: 2013-02-15
Published online: 2006-06-26
Potential application of stem cells in urogynecology
Aneta Adamiak, Tomasz Rechberger
Endokrynol Pol 2005;56(6):994-997.
Vol 56, No 6 (2005)
Review Article
Submitted: 2013-02-15
Published online: 2006-06-26
Abstract
Recent advances in stem cells therapy and tissue engineering techniques hold great promise for recovery of external urethral sphincter proper functioning and urinary incontinent patients treatment. Adult stem cells (ASCs) may be derived from striated muscles, fat tissue or as mesenchymal cells from bone marrow. These cells can differentiate in functionally normal smooth or striated muscle cells. ASCs injected to external urethral sphincter or bladder neck cause the increase in urethral closure pressure. Favourable findings of trials in animal models and in vitro encouraged to first trials in humans and hold a promising future for the treatment of urinary incontinence.
Abstract
Recent advances in stem cells therapy and tissue engineering techniques hold great promise for recovery of external urethral sphincter proper functioning and urinary incontinent patients treatment. Adult stem cells (ASCs) may be derived from striated muscles, fat tissue or as mesenchymal cells from bone marrow. These cells can differentiate in functionally normal smooth or striated muscle cells. ASCs injected to external urethral sphincter or bladder neck cause the increase in urethral closure pressure. Favourable findings of trials in animal models and in vitro encouraged to first trials in humans and hold a promising future for the treatment of urinary incontinence.
Keywords
stem cells; urinary incontinence
Title
Potential application of stem cells in urogynecology
Journal
Endokrynologia Polska
Issue
Vol 56, No 6 (2005)
Article type
Review paper
Pages
994-997
Published online
2006-06-26
Page views
794
Article views/downloads
1989
Bibliographic record
Endokrynol Pol 2005;56(6):994-997.
Keywords
stem cells
urinary incontinence
Authors
Aneta Adamiak
Tomasz Rechberger