open access

Vol 56, No 6 (2005)
Original papers
Published online: 2006-06-26
Submitted: 2013-02-15
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Reversal of the sex difference in plasma leptin levels in obese children with impaired glucose tolerance

Barbara Garanty-Bogacka, Małgorzata Syrenicz, Anhelli Syrenicz, Aneta Gębala, Mieczysław Walczak
Endokrynologia Polska 2005;56(6):917-920.

open access

Vol 56, No 6 (2005)
Original papers
Published online: 2006-06-26
Submitted: 2013-02-15

Abstract

Introduction: Basal leptin level has been demonstrated to correlate positively with many indices of obesity, as well as insulin resistance. However, to date, little is known about regulation of leptin in obese children with incipient glucose metabolic disorders.
Objective: The aim of this study was to define the precise influence of the glucose tolerance status on plasma leptin in obese boys and girls separately.
Material and methods: 70 obese children with impaired glucose tolerance (IGT) and well-matched 70 normal glucose-tolerant (NGT) subjects were examined. Fasting and 2-h post glucose load plasma glucose and insulin levels as well as fasting leptin levels were determined, apart from anthropometric measurements.
Results: Leptin levels were significantly lower in girls with IGT compared to NGT girl (17.7&#177;6.5 &#181;g/L vs. 23.1&#177;7.7 &#181;g/L; p<.001). No such difference was observed in boys. In a multiple regression analysis adjusting for age and adiposity, in the female group plasma glucose and insulin levels 2-h after glucose load were the best predictors of fasting plasma leptin (r = -0.49, p<.005 and r = 0.34, p<.05; respectively). In boys, plasma insulin level 2-h after glucose load was the independent determinant of leptin (r = 0.36, p<.05).
Conclusion: The differences between regulation of leptin synthesis in girls and boys with simple obesity were found. The stimulatory effect of insulin on leptin synthesis was greater in girls with normoglycemia than in girls with impaired glucose tolerance.

Abstract

Introduction: Basal leptin level has been demonstrated to correlate positively with many indices of obesity, as well as insulin resistance. However, to date, little is known about regulation of leptin in obese children with incipient glucose metabolic disorders.
Objective: The aim of this study was to define the precise influence of the glucose tolerance status on plasma leptin in obese boys and girls separately.
Material and methods: 70 obese children with impaired glucose tolerance (IGT) and well-matched 70 normal glucose-tolerant (NGT) subjects were examined. Fasting and 2-h post glucose load plasma glucose and insulin levels as well as fasting leptin levels were determined, apart from anthropometric measurements.
Results: Leptin levels were significantly lower in girls with IGT compared to NGT girl (17.7&#177;6.5 &#181;g/L vs. 23.1&#177;7.7 &#181;g/L; p<.001). No such difference was observed in boys. In a multiple regression analysis adjusting for age and adiposity, in the female group plasma glucose and insulin levels 2-h after glucose load were the best predictors of fasting plasma leptin (r = -0.49, p<.005 and r = 0.34, p<.05; respectively). In boys, plasma insulin level 2-h after glucose load was the independent determinant of leptin (r = 0.36, p<.05).
Conclusion: The differences between regulation of leptin synthesis in girls and boys with simple obesity were found. The stimulatory effect of insulin on leptin synthesis was greater in girls with normoglycemia than in girls with impaired glucose tolerance.
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Keywords

leptin; impaired glucose tolerance; simple obesity

About this article
Title

Reversal of the sex difference in plasma leptin levels in obese children with impaired glucose tolerance

Journal

Endokrynologia Polska

Issue

Vol 56, No 6 (2005)

Pages

917-920

Published online

2006-06-26

Bibliographic record

Endokrynologia Polska 2005;56(6):917-920.

Keywords

leptin
impaired glucose tolerance
simple obesity

Authors

Barbara Garanty-Bogacka
Małgorzata Syrenicz
Anhelli Syrenicz
Aneta Gębala
Mieczysław Walczak

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