open access

Vol 56, No 6 (2005)
Original papers
Published online: 2006-06-26
Submitted: 2013-02-15
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Age, insulin, SHBG and sex steroids exert secondary influence on plasma leptin level in women

Tomasz Milewicz, Józef Krzysiek, Agnieszka Janczak-Saif, Krystyna Sztefko, Magdalena
Endokrynologia Polska 2005;56(6):883-890.

open access

Vol 56, No 6 (2005)
Original papers
Published online: 2006-06-26
Submitted: 2013-02-15

Abstract

Aim. As the link between body fat and leptin is well known, the aim of the study was to seek for secondary regulators of plasma leptin level. Patients. 86 women (mean: age 47.0±14.3 years; estradiol 50.0±60.6 ng/l; FSH 52.4±42.9 IU/l; BMI 26.9±5.9) divided into three groups according to their BMI. Group A: 39 normal weight women (mean: age 44.4±16.0 years; estradiol 69.6±79.8 ng/l; FSH 50.4±47.7 IU/l; BMI 22.9±1.3). Group B: 27 overweighted women (mean: age 55.0±6.4 years; estradiol 25.1±17.2 ng/l; FSH 75.6±26.3 IU/l; BMI 27.7±1.6). Group C: 21 obese women with mean: age 48.7±12.2 years; estradiol 36.9±44.0 ng/l; FSH 42.3±36.6 IU/l and BMI 34.6±4.9.
Methods. Standard clinical evaluation and hormone evaluation (LH, FSH, prolactin, estradiol, leptin, insulin-like growth factor-I (IGF-I), human growth hormone (hGH), insulin-like growth factor binding protein-3 (IGFBP-3), insulin, dihydroepiandrosterone sulphate (DHEAS), sex hormone binding globin (SHBG) and testosterone were done in basic condition which levels of were measured by RIA kits.
Statistical analysis. Shapiro-Wilk test, Mann-Whitney-Wilcoxon u test, Spearman rank correlation coefficient and stepwise multiple regression: p values of 0.05 or less were considered as significant.
Results. Taking all women into account (n=86) the plasma leptin level correlated directly with age (r=0.32; p

Abstract

Aim. As the link between body fat and leptin is well known, the aim of the study was to seek for secondary regulators of plasma leptin level. Patients. 86 women (mean: age 47.0±14.3 years; estradiol 50.0±60.6 ng/l; FSH 52.4±42.9 IU/l; BMI 26.9±5.9) divided into three groups according to their BMI. Group A: 39 normal weight women (mean: age 44.4±16.0 years; estradiol 69.6±79.8 ng/l; FSH 50.4±47.7 IU/l; BMI 22.9±1.3). Group B: 27 overweighted women (mean: age 55.0±6.4 years; estradiol 25.1±17.2 ng/l; FSH 75.6±26.3 IU/l; BMI 27.7±1.6). Group C: 21 obese women with mean: age 48.7±12.2 years; estradiol 36.9±44.0 ng/l; FSH 42.3±36.6 IU/l and BMI 34.6±4.9.
Methods. Standard clinical evaluation and hormone evaluation (LH, FSH, prolactin, estradiol, leptin, insulin-like growth factor-I (IGF-I), human growth hormone (hGH), insulin-like growth factor binding protein-3 (IGFBP-3), insulin, dihydroepiandrosterone sulphate (DHEAS), sex hormone binding globin (SHBG) and testosterone were done in basic condition which levels of were measured by RIA kits.
Statistical analysis. Shapiro-Wilk test, Mann-Whitney-Wilcoxon u test, Spearman rank correlation coefficient and stepwise multiple regression: p values of 0.05 or less were considered as significant.
Results. Taking all women into account (n=86) the plasma leptin level correlated directly with age (r=0.32; p
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Keywords

leptin; age; insulin; SHBG; sex steroids

About this article
Title

Age, insulin, SHBG and sex steroids exert secondary influence on plasma leptin level in women

Journal

Endokrynologia Polska

Issue

Vol 56, No 6 (2005)

Pages

883-890

Published online

2006-06-26

Bibliographic record

Endokrynologia Polska 2005;56(6):883-890.

Keywords

leptin
age
insulin
SHBG
sex steroids

Authors

Tomasz Milewicz
Józef Krzysiek
Agnieszka Janczak-Saif
Krystyna Sztefko
Magdalena

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