open access

Vol 56, No 6 (2005)
Original papers
Published online: 2006-06-26
Submitted: 2013-02-15
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17β-estradiol regulation of human growth hormone (hGH), insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) axis in hypoestrogenic, hypergonadotropic women

Tomasz Milewicz, Józef Krzysiek, Krystyna Sztefko, Stanisław Radowicki, Magdalena Krzyczkowska-Sendrakowska
Endokrynologia Polska 2005;56(6):876-882.

open access

Vol 56, No 6 (2005)
Original papers
Published online: 2006-06-26
Submitted: 2013-02-15

Abstract

Objective. Ovarian hormonal function may be as important contributing factor to hGH-IGF-I-IGFBP-3 axis as age.
Aim. To examine plasma hGH, IGF-1 and IGFBP-3 levels in women with premature ovarian failure compared to healthy normal controls and postmenopausal ones.
Patients. Group A-15 women with premature ovarian failure (POF) (mean: age 38.9±5.2 years, FSH 101.4±29.0 IU/l; 17β-estradiol 22.5±14.6 ng/l). Group B consisted of 15 menopausal women (mean: age 54.7±2.7 years; FSH 81.9±32.1 IU/l; 17β-estradiol 17.1± 8.0 ng/l). Group C – controls – 15 normally menstruating women (mean: age 37.1±9.0 years; FSH 6.2±1.0 IU/l; 17β-estradiol 144.8±117.1 ng/l).
Methods. Body mass and BMI were measured. Basic fasting plasma hGH, IGF-I, IGFBP-3, insulin, testosterone and LH as well as prolactin (PRL), FSH and estradiol were assessed by RIA kits. Statistical analysis. Shapiro-Wilk test, Mann-Whitney u-test, Spearman rang correlation coefficient, stepwise multiple regression.
Results. Mean serum IGF-I level was the lowest (p<0.005) in group B (172.0&plusmn;54.6 &micro;g/l) and the highest in group C (273.6&plusmn;109.0 &micro;g/l). The mean plasma IGF-I level in group A was similar (NS) (208.3&plusmn;66.5 &micro;g/l) to that found in group B and lower (p<0.02) compared with that in group C. The lowest (p<0.005) serum IGFBP-3 level was found in group B (3.1&plusmn;0.7 &micro;g/l) compared to group C (4.4&plusmn;0.3 &micro;g/l). The mean plasma IGFBP-3 level (3.1&plusmn;1.0 &micro;g/l) in group A was lower than in group C (p<0.005) but identical as in group B. No statistically significant differences between groups were observed in mean hGH levels. Women in group A and C were younger (p<0.001) than those in group B. The lowest mean estradiol level was found in groups A and B. The highest was in group C (p<0.001). Mean plasma LH and FSH levels were higher (p<0.001) in groups A and B vs group C. In group C there were links between IGF-I and age (r=-0.60; p=0.014) The IGF-I/age relation disappeared in the groups A and B (rA=-0.26; rB=0.10; NS). The same regards IGFBP-3/ age link (rA=-0.44, NS; rB=0,31;NS). Estradiol level was related to hGH levels in group C (r=-0.54; p<0.05). In none of groups hGH/IGF-1 as well as IGFBP-3/hGH relations were found. Prolactin accounted for 69% of the variance in IGF-I level in the group B (p=0.003) and for 24% in group A (NS). Testosterone accounted for 88% (p=0.004) of the variance in IGF-I level in group B and IGFBP-3 was responsible for 86% (p=0.038) of the variance in IGF-I level in group C. Again IGFBP-3 was responsible for 47% (p=0.023) in group A and for 49% (p=0.04) in group B of the hGH variance.
Conclusions. 17b-estradiol may be as important contributor to insulin-like growth factor-I (IGF-I) plasma level as age in hypoestrogenic, hypogonadotropic women.

Abstract

Objective. Ovarian hormonal function may be as important contributing factor to hGH-IGF-I-IGFBP-3 axis as age.
Aim. To examine plasma hGH, IGF-1 and IGFBP-3 levels in women with premature ovarian failure compared to healthy normal controls and postmenopausal ones.
Patients. Group A-15 women with premature ovarian failure (POF) (mean: age 38.9&plusmn;5.2 years, FSH 101.4&plusmn;29.0 IU/l; 17&#946;-estradiol 22.5&plusmn;14.6 ng/l). Group B consisted of 15 menopausal women (mean: age 54.7&plusmn;2.7 years; FSH 81.9&plusmn;32.1 IU/l; 17&#946;-estradiol 17.1&plusmn; 8.0 ng/l). Group C &#8211; controls &#8211; 15 normally menstruating women (mean: age 37.1&plusmn;9.0 years; FSH 6.2&plusmn;1.0 IU/l; 17&#946;-estradiol 144.8&plusmn;117.1 ng/l).
Methods. Body mass and BMI were measured. Basic fasting plasma hGH, IGF-I, IGFBP-3, insulin, testosterone and LH as well as prolactin (PRL), FSH and estradiol were assessed by RIA kits. Statistical analysis. Shapiro-Wilk test, Mann-Whitney u-test, Spearman rang correlation coefficient, stepwise multiple regression.
Results. Mean serum IGF-I level was the lowest (p<0.005) in group B (172.0&plusmn;54.6 &micro;g/l) and the highest in group C (273.6&plusmn;109.0 &micro;g/l). The mean plasma IGF-I level in group A was similar (NS) (208.3&plusmn;66.5 &micro;g/l) to that found in group B and lower (p<0.02) compared with that in group C. The lowest (p<0.005) serum IGFBP-3 level was found in group B (3.1&plusmn;0.7 &micro;g/l) compared to group C (4.4&plusmn;0.3 &micro;g/l). The mean plasma IGFBP-3 level (3.1&plusmn;1.0 &micro;g/l) in group A was lower than in group C (p<0.005) but identical as in group B. No statistically significant differences between groups were observed in mean hGH levels. Women in group A and C were younger (p<0.001) than those in group B. The lowest mean estradiol level was found in groups A and B. The highest was in group C (p<0.001). Mean plasma LH and FSH levels were higher (p<0.001) in groups A and B vs group C. In group C there were links between IGF-I and age (r=-0.60; p=0.014) The IGF-I/age relation disappeared in the groups A and B (rA=-0.26; rB=0.10; NS). The same regards IGFBP-3/ age link (rA=-0.44, NS; rB=0,31;NS). Estradiol level was related to hGH levels in group C (r=-0.54; p<0.05). In none of groups hGH/IGF-1 as well as IGFBP-3/hGH relations were found. Prolactin accounted for 69% of the variance in IGF-I level in the group B (p=0.003) and for 24% in group A (NS). Testosterone accounted for 88% (p=0.004) of the variance in IGF-I level in group B and IGFBP-3 was responsible for 86% (p=0.038) of the variance in IGF-I level in group C. Again IGFBP-3 was responsible for 47% (p=0.023) in group A and for 49% (p=0.04) in group B of the hGH variance.
Conclusions. 17b-estradiol may be as important contributor to insulin-like growth factor-I (IGF-I) plasma level as age in hypoestrogenic, hypogonadotropic women.
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Keywords

IGF-I; IGFBP-3; hGH; estadiol; POF

About this article
Title

17β-estradiol regulation of human growth hormone (hGH), insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) axis in hypoestrogenic, hypergonadotropic women

Journal

Endokrynologia Polska

Issue

Vol 56, No 6 (2005)

Pages

876-882

Published online

2006-06-26

Bibliographic record

Endokrynologia Polska 2005;56(6):876-882.

Keywords

IGF-I
IGFBP-3
hGH
estadiol
POF

Authors

Tomasz Milewicz
Józef Krzysiek
Krystyna Sztefko
Stanisław Radowicki
Magdalena Krzyczkowska-Sendrakowska

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