open access

Vol 56, No 6 (2005)
Original papers
Published online: 2006-06-26
Submitted: 2013-02-15
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17β-estradiol regulation of human growth hormone (hGH), insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) axis in hypoestrogenic, hypergonadotropic women

Tomasz Milewicz, Józef Krzysiek, Krystyna Sztefko, Stanisław Radowicki, Magdalena Krzyczkowska-Sendrakowska
Endokrynologia Polska 2005;56(6):876-882.

open access

Vol 56, No 6 (2005)
Original papers
Published online: 2006-06-26
Submitted: 2013-02-15

Abstract

Objective. Ovarian hormonal function may be as important contributing factor to hGH-IGF-I-IGFBP-3 axis as age.
Aim. To examine plasma hGH, IGF-1 and IGFBP-3 levels in women with premature ovarian failure compared to healthy normal controls and postmenopausal ones.
Patients. Group A-15 women with premature ovarian failure (POF) (mean: age 38.9±5.2 years, FSH 101.4±29.0 IU/l; 17β-estradiol 22.5±14.6 ng/l). Group B consisted of 15 menopausal women (mean: age 54.7±2.7 years; FSH 81.9±32.1 IU/l; 17β-estradiol 17.1± 8.0 ng/l). Group C – controls – 15 normally menstruating women (mean: age 37.1±9.0 years; FSH 6.2±1.0 IU/l; 17β-estradiol 144.8±117.1 ng/l).
Methods. Body mass and BMI were measured. Basic fasting plasma hGH, IGF-I, IGFBP-3, insulin, testosterone and LH as well as prolactin (PRL), FSH and estradiol were assessed by RIA kits. Statistical analysis. Shapiro-Wilk test, Mann-Whitney u-test, Spearman rang correlation coefficient, stepwise multiple regression.
Results. Mean serum IGF-I level was the lowest (p

Abstract

Objective. Ovarian hormonal function may be as important contributing factor to hGH-IGF-I-IGFBP-3 axis as age.
Aim. To examine plasma hGH, IGF-1 and IGFBP-3 levels in women with premature ovarian failure compared to healthy normal controls and postmenopausal ones.
Patients. Group A-15 women with premature ovarian failure (POF) (mean: age 38.9±5.2 years, FSH 101.4±29.0 IU/l; 17β-estradiol 22.5±14.6 ng/l). Group B consisted of 15 menopausal women (mean: age 54.7±2.7 years; FSH 81.9±32.1 IU/l; 17β-estradiol 17.1± 8.0 ng/l). Group C – controls – 15 normally menstruating women (mean: age 37.1±9.0 years; FSH 6.2±1.0 IU/l; 17β-estradiol 144.8±117.1 ng/l).
Methods. Body mass and BMI were measured. Basic fasting plasma hGH, IGF-I, IGFBP-3, insulin, testosterone and LH as well as prolactin (PRL), FSH and estradiol were assessed by RIA kits. Statistical analysis. Shapiro-Wilk test, Mann-Whitney u-test, Spearman rang correlation coefficient, stepwise multiple regression.
Results. Mean serum IGF-I level was the lowest (p
Get Citation

Keywords

IGF-I; IGFBP-3; hGH; estadiol; POF

About this article
Title

17β-estradiol regulation of human growth hormone (hGH), insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) axis in hypoestrogenic, hypergonadotropic women

Journal

Endokrynologia Polska

Issue

Vol 56, No 6 (2005)

Pages

876-882

Published online

2006-06-26

Bibliographic record

Endokrynologia Polska 2005;56(6):876-882.

Keywords

IGF-I
IGFBP-3
hGH
estadiol
POF

Authors

Tomasz Milewicz
Józef Krzysiek
Krystyna Sztefko
Stanisław Radowicki
Magdalena Krzyczkowska-Sendrakowska

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