open access

Vol 56, No 6 (2005)
Original papers
Published online: 2006-06-26
Submitted: 2013-02-15
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Alendronate increases bone mineral density in patients with symptomatic primary hyperparathyroidism

Waldemar Misiorowski
Endokrynologia Polska 2005;56(6):871-875.

open access

Vol 56, No 6 (2005)
Original papers
Published online: 2006-06-26
Submitted: 2013-02-15

Abstract

Primary hyperparathyroidism (PHPT) is often associated with low bone mineral density (BMD). An open-labeled, prospective trial was conducted to determine whether alendronate (ALN), 10 mg daily, maintains or improves BMD in patients with advanced PHPT. All patients had symptomatic PHPT and met surgical guidelines however refused surgery. Nineteen patients was treated with alendronate for 2 years. The primary outcome index, BMD, was measured at the lumbar spine (LS) and femoral neck (FN) every 6 months by dual-energy x-ray absorptiometry. Serum calcium, phosphorous and PTH, and urinary calcium excretion were monitored every 3 months. Treatment with alendronate over 2 years was associated with a significant (5.3 ± 0.4%; p

Abstract

Primary hyperparathyroidism (PHPT) is often associated with low bone mineral density (BMD). An open-labeled, prospective trial was conducted to determine whether alendronate (ALN), 10 mg daily, maintains or improves BMD in patients with advanced PHPT. All patients had symptomatic PHPT and met surgical guidelines however refused surgery. Nineteen patients was treated with alendronate for 2 years. The primary outcome index, BMD, was measured at the lumbar spine (LS) and femoral neck (FN) every 6 months by dual-energy x-ray absorptiometry. Serum calcium, phosphorous and PTH, and urinary calcium excretion were monitored every 3 months. Treatment with alendronate over 2 years was associated with a significant (5.3 ± 0.4%; p
Get Citation

Keywords

alendronate; primary hyperparathyroidism; bone mineral density

About this article
Title

Alendronate increases bone mineral density in patients with symptomatic primary hyperparathyroidism

Journal

Endokrynologia Polska

Issue

Vol 56, No 6 (2005)

Pages

871-875

Published online

2006-06-26

Bibliographic record

Endokrynologia Polska 2005;56(6):871-875.

Keywords

alendronate
primary hyperparathyroidism
bone mineral density

Authors

Waldemar Misiorowski

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