open access

Vol 56, No 6 (2005)
Original papers
Published online: 2006-06-26
Submitted: 2013-02-15
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Decrease in serum ghrelin levels in patients with acromegaly normalize after successful surgical treatment

Jarosław Kozakowski, Michał Rabijewski, Wojciech Zgliczyński
Endokrynologia Polska 2005;56(6):862-869.

open access

Vol 56, No 6 (2005)
Original papers
Published online: 2006-06-26
Submitted: 2013-02-15

Abstract

Ghrelin has been found as a natural ligand of growth hormone secretagouges receptors (GHSR-1a) that exerts a marked stimulatory effect on growth hormone (GH) secretion. It is also thought to be involved of eating behavior and control of energy homeostasis. However, still little is known about the physiology of ghrelin secretion in acromegaly.
Objective. The objective of the study was to examine effects of surgical and pharmacological treatment in patients with acromegaly on serum ghrelin levels.
Material. 28 patients (17 women and 11 men) aged 47,7 ±11,4 years (mean ±SD) with body mass index (BMI) = 31,6 ±4,9 kg/m2. Diagnosis was based on: 1/ peak GH in oral glucose tolerance test ≥1ng/mL, 2/ serum IGF-1 levels above normal for gender and age, 3/ pituitary adenoma in magnetic resonance imagining. Patients were divided into two groups: Group I – surgically treated (transsphenoidal surgery): 10 women and 7 men aged 45 ±10,9 years with BMI = 31,3 ±4,9 kg/m2. Criteria of cure in acromaegaly were: 1/ peak GH

Abstract

Ghrelin has been found as a natural ligand of growth hormone secretagouges receptors (GHSR-1a) that exerts a marked stimulatory effect on growth hormone (GH) secretion. It is also thought to be involved of eating behavior and control of energy homeostasis. However, still little is known about the physiology of ghrelin secretion in acromegaly.
Objective. The objective of the study was to examine effects of surgical and pharmacological treatment in patients with acromegaly on serum ghrelin levels.
Material. 28 patients (17 women and 11 men) aged 47,7 ±11,4 years (mean ±SD) with body mass index (BMI) = 31,6 ±4,9 kg/m2. Diagnosis was based on: 1/ peak GH in oral glucose tolerance test ≥1ng/mL, 2/ serum IGF-1 levels above normal for gender and age, 3/ pituitary adenoma in magnetic resonance imagining. Patients were divided into two groups: Group I – surgically treated (transsphenoidal surgery): 10 women and 7 men aged 45 ±10,9 years with BMI = 31,3 ±4,9 kg/m2. Criteria of cure in acromaegaly were: 1/ peak GH
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Keywords

ghrelin; growth hormone; acromegaly

About this article
Title

Decrease in serum ghrelin levels in patients with acromegaly normalize after successful surgical treatment

Journal

Endokrynologia Polska

Issue

Vol 56, No 6 (2005)

Pages

862-869

Published online

2006-06-26

Bibliographic record

Endokrynologia Polska 2005;56(6):862-869.

Keywords

ghrelin
growth hormone
acromegaly

Authors

Jarosław Kozakowski
Michał Rabijewski
Wojciech Zgliczyński

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